Effects of coadministration of berberine chloride with cyclosporin on liver microsomal cytochrome P450 isoenzyme and mdr1 in rats

Chinese Pharmacological Bulletin

Volumn 18, Issue 4, 2002, Pages 397-401

  Xin, Hua Wen ^a   Wu, Xiao Chun ^a   Li, Qing ^a   Yu, Ai Rong ^a   Zhong, Ming Yuan ^a   Zhu, Min ^a   Liu, You Ying ^a  

^a WUHAN GENERAL HOSPITAL OF GUANGZHOU COMMAND   (China)

Author keywords

Berberine chloride; Cyclosporin; Cytochrome P450; Multidrug resistance gene

Indexed keywords

AMINOPYRENE N DEMETHYLASE; BERBERINE; CYCLOSPORIN A; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 2E1; CYTOCHROME P450 3A1; ERYTHROMYCIN DEMETHYLASE; KETOCONAZOLE; MULTIDRUG RESISTANCE PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ELIMINATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INHIBITION; LIVER MICROSOME; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0036670112     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. The pharmacokinetics of enhancement of cyclosporin A by berberine chloride coadministrated in renal transplanted recipients
2. Analysis of rat cytochrome P450 isoenzyme expression using semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR)
3. Differential over-expression of mdr1 genes in multidrug-resisitant rat glioblastoma cell lines selected with doxorubicin or vincristine
4. Oxidative and reductive metabolism by cytochrome P4502E1
5. Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells
6. P-glycoprotein and drug therapy in organ transplantation