Reduction of excitatory transmission in the retino-collicular pathway via selective activation of mGlu8 receptors by DCPG

Neuropharmacology

Volumn 43, Issue 2, 2002, Pages 231-234

  Pothecary, C A ^a   Jane, D E ^b   Salt, T E ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

(S) 3,4 dicarboxyphenylglycine; mGlu8 receptor; mGluR8; Presynaptic; Superior Colliculus

Indexed keywords

2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; 2 AMINO 4 PHOSPHONOBUTYRIC ACID; 3,4 DICARBOXYPHENYLGLYCINE; 4 AMINOBUTYRIC ACID RECEPTOR; BENZYL[3 [[1 (3,4 DICHLOROPHENYL)ETHYL]AMINO] 2 HYDROXYPROPYL]PHOSPHINIC ACID; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR AGONIST; PICROTOXIN; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; EXCITATORY POSTSYNAPTIC POTENTIAL; NEUROMODULATION; NONHUMAN; OPTIC TRACT; PRIORITY JOURNAL; RECEPTOR BLOCKING; RECEPTOR UPREGULATION; RETINA; SUPERIOR COLLICULUS; SYNAPTIC TRANSMISSION;

ANIMALS; BENZOATES; EXCITATORY POSTSYNAPTIC POTENTIALS; GLYCINE; NEURAL PATHWAYS; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; SUPERIOR COLLICULUS;

EID: 0036669431     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(02)00077-1     Document Type: Article

References (20)

1. Akazawa C., Ohishi H., Nakajima Y., Okamoto N., Shigemoto R., Nakanishi S., Mizuno N. Expression of mRNAs of L-AP4-sensitive metabotropic glutamate receptors (mGluR4, mGluR6, mGluR7) in the rat retina. Neuroscience Letters. 171:1994;52-54.
2. Binns K.E., Salt T.E. Excitatory amino acid receptors participate in synaptic transmission of visual responses in the superficial layers of the cat superior colliculus. European Journal of Neuroscience. 6:1994;161-169.
3. Binns K.E., Salt T.E. Different roles for GABAa and GABAb receptors in visual processing in the rat superior colliculus. Journal of Physiology. 504:1997;629-639.
4. Bradley S.R., Rees H.D., Yi H., Levey A.I., Conn P.J. Distribution and developmental regulation of metabotropic glutamate receptor 7a in rat brain. Journal of Neurochemistry. 71:1998;636-645.
5. Cirone J., Pothecary C.A., Turner J.P., Salt T.E. Group I metabotropic glutamate receptors (mGluRs) modulate visual responses in the superficial superior colliculus of the rat. Journal of Physiology. 541:2002;895-903.
6. Cirone J., Salt T.E. Group II and III metabotropic glutamate (mGlu) receptors contribute to different aspects of visual response processing in the superior colliculus. Journal of Physiology. 534:2001;169-178.
7. Conn P.J., Pin J.P. Pharmacology and functions of metabotropic glutamate receptors. Annual Review of Pharmacology and Toxicology. 37:1997;207-237.
8. Duvoisin R.M., Zhang C., Ramonell K. A novel metabotropic glutamate receptor expressed in the retina and olfactory bulb. Journal of Neuroscience. 15:1995;3075-3083.
9. Hartveit E., Brandstätter J.H., Enz R., Wässle H. Expression of the mRNA of seven metabotropic glutamate receptors (mGluR1 to 7) in the rat retina. An in situ hybridization study on tissue sections and isolated cells. European Journal of Neuroscience. 7:1995;1472-1483.
10. Kingston A.E., Ornstein P.L., Wright R.A., Johnson B.G., Mayne N.G., Burnett J.P., Belagaje R., Wu S., Schoepp D.D. LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors. Neuropharmacology. 37:1998;1-12.
11. Kinzie J.M., Saugstad J.A., Westbrook G.L., Segerson T.P. Distribution of metabotropic glutamate-receptor-7 messenger-RNA in the developing and adult-rat brain. Neuroscience. 69:1995;167-176.
12. Koulen P., Kuhn R., Wässle H., Brandstätter J.H. Modulation of the intracellular calcium concentration in photoreceptor terminals by a presynaptic metabotropic glutamate receptor. Proceedings of the National Academy of Sciences of the United States of America. 96:1999;9909-9914.
13. Ohishi H., Akazawa C., Shigemoto R., Nakanishi S., Mizuno N. Distributions of the mRNAs for L-2-amino-4-phosphonobutyrate-sensitive metabotropic glutamate receptors, mGluR4 and mGluR7, in the rat brain. Journal of Comparative Neurology. 360:1995;555-570.
14. Platt B., Withington D.J. Response habituation in the superficial layers of the guinea-pig superior colliculus in vitro. Neuroscience Letters. 221:1997;153-156.
15. Roberts W.A., Eaton S.A., Salt T.E. Excitatory amino acid receptors mediate synaptic responses to visual stimuli in superior colliculus neurones of the rat. Neuroscience Letters. 129:1991;161-164.
16. Saugstad J.A., Kinzie J.M., Shinohara M.M., Segerson T.P., Westbrook G.L. Cloning and expression of rat metabotropic glutamate receptor 8 reveals a distinct pharmacological profile. Molecular Pharmacology. 51:1997;119-125.
17. Schmidt M., Boller M., Ozen G., Hall W.C. Disinhibition in rat superior colliculus mediated by gaba(c) receptors. Journal of Neuroscience. 21:2001;691-699.
18. Stein B.E., Meredith M.A. The Merging of the Senses. 1993;MIT Press, Cambridge, MA, USA.
19. Thomas N.K., Clayton P., Jane D.E. Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones. European Journal of Pharmacology. 338:1997;111-116.
20. Thomas N.K., Wright R.A., Howson P.A., Kingston A.E., Schoepp D.D., Jane D.E. (S)-3-4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology. 40:2001;311-318.