Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones

European Journal of Pharmacology

Volumn 338, Issue 2, 1997, Pages 111-116

  Thomas, Nicola K ^a   Clayton, Peter ^a   Jane, David E ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Glutamate receptor; Neonatal rat spinal cord; Novel antagonist

Indexed keywords

3,4 DICARBOXYPHENYLGLYCINE; 3,5 DICARBOXYPHENYLGLYCINE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMINO ACID RECEPTOR BLOCKING AGENT; GLUTAMATE RECEPTOR; IONOTROPIC RECEPTOR; KAINIC ACID; METABOTROPIC RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DEPOLARIZATION; DRUG EFFECT; MOTONEURON; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; SPINAL CORD;

EID: 0030669518     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)81937-1     Document Type: Article

References (11)

1. Birse E.F., Eaton S.A., Jane D.E., Jones P.L.St.J., Porter R.H.P., Pook P.C.-K., Sunter D.C., Udvarhelyi P.M., Wharton B., Roberts P.J., Salt T.E., Watkins J.C. Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system. Neuroscience. 52:1993;481-488.
2. Evans R.H., Francis A.A., Jones A.W., Smith D.A.S., Watkins J.C. The effects of a series of ω-phosphonic α-carboxylic amino acids on electrically evoked and amino acid induced responses in isolated spinal cord preparations. Br. J. Pharmacol. 75:1982;65-75.
3. Jane, D.E., Olverman, H.J., Watkins, J.C., 1995. Agonists and competitive antagonists: Structure activity and molecular modelling studies. In: Collingridge, G.L., Watkins, J.C. (Eds.), The NMDA Receptor, 2nd ed. Oxford University Press, Oxford, UK, pp. 31-104.
4. Liu H., Wang H., Sheng M., Jan L.Y., Jan Y.N., Basbaum A.I. Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn. Proc. Natl. Acad. Sci. USA. 91:1994;8383-8387.
5. Nakanishi S., Masu M. Molecular diversity and functions of glutamate receptors. Annu. Rev. Biophys. Biomol. Struct. 23:1994;319-348.
6. Pin J.-P., Duvoisin R. The metabotropic glutamate receptors: Structure and functions. Neuropharmacology. 34:1995;1-26.
7. Pook P.C.-K., Brugger F., Hawkins N.S., Clark K.C., Watkins J.C., Evans R.H. A comparison of the actions of agonists and antagonists at non-NMDA receptors of C fibres and motoneurones of the immature rat spinal cord in vitro. Br. J. Pharmacol. 108:1993;179-184.
8. Steiger, R.E., 1955. α-Aminodiethylacetic acid. In: Organic Synthesis Coll., vol. 3, p. 66.
9. Udvarhelyi P.M., Watkins J.C. Direct resolution of some phenylglycines by liquid chromatography on a chiral crown-ether phase. Chirality. 2:1990;200-204.
10. Watkins J.C., Collingridge G.L. Phenylglycine derivatives as antagonists of metabotropic glutamate receptors. Trends. Pharmacol. Sci. 15:1994;333-342.
11. Watkins, J.C., Krogsgaard-Larsen, P., Honore, T., 1991. The pharmacology of excitatory amino acids, A special report. Trends Pharmacol. Sci., 4-12.