Reflections on a novel therapeutic candidate

Chemistry and Biology

Volumn 9, Issue 8, 2002, Pages 857-858

  Sooter, Letha J ^a   Ellington, Andrew D ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0036669207     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(02)00190-4     Document Type: Review

References (9)

1. Leva S., Lichte A., Burmeister J., Muhn P., Jahnke B., Fesser D., Erfurth J., Burgstaller P., Klussmann S. GnRH binding RNA and DNA Spiegelmers. a novel approach toward GnRH antagonism Chem. Biol. 9:2002;351-359.
2. Wlotzka B., Leva S., Eschgfäller B., Burmeister J., Kleinjung F., Kaduk C., Muhn P., Hess-Stumpp H., Klussmann S. In vivo properties of an anti-GnRH Spiegelmer. an example of an oligonucleotide-based therapeutic substance class Proc. Natl. Acad. Sci. USA. 99:2002;8898-8902.
3. Nolte A., Klussmann S., Bald R., Erdmann V.A., Fürste J.P. Mirror-design of L-oligonucleotide ligands binding to L-arginine. Nat. Biotechnol. 14:1996;1116-1119.
4. Klussmann S., Nolte A., Bald R., Erdmann V.A., Fürste J.P. Mirror-image RNA that binds D-adenosine. Nat. Biotechnol. 14:1996;1112-1115.
5. Williams K.P., Liu X.H., Schumacher T.N.M., Lin H.Y., Ausiello D.A., Kim P.S., Bartel D.P. Bioactive and nuclease-resistant L-DNA ligand of vasopressin. Proc. Natl. Acad. Sci. USA. 94:1997;11285-11290.
6. Schumacher T.N.M., Mayr L.M., Minor D.L. Jr., Milhollen M.A., Burgess M.W., Kim P.S. Identification of D-peptide ligands through mirror-image phage display. Science. 271:1996;1854-1857.
7. Bell C., Lynam E., Landfair D.J., Janjic N., Wiles M.E. Oligonucleotide NX1838 inhibits VEGF165-mediated cellular responses in vitro. In Vitro Cell. Dev. Biol. Anim. 35:1999;533-542.
8. Ostendorf T., Kunter U., Eitner F., Loos A., Regele H., Kerjaschki D., Henninger D.D., Janjic N., Floege J. VEGF(165) mediates glomerular endothelial repair. J. Clin. Invest. 104:1999;913-923.
9. Brody E.N., Gold L. Aptamers as therapeutic and diagnostic agents. J. Biotechnol. 74:2000;5-13.