Changes in bile acid composition and effect on cytolytic activity of fecal water by ursodeoxycholic acid administration: A placebo-controlled cross-over intervention trial in healthy volunteers

Scandinavian Journal of Gastroenterology

Volumn 37, Issue 8, 2002, Pages 965-971

  Van Gorkom, B A P ^a   Van der Meer, R ^a   Boersma Van Ek, W ^a   Termont, D S M L ^a   De Vries, E G E ^a   Kleibeuker, J H ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Biomarkers; Chemoprevention; Colon carcinogenesis; Fecal water; UDCA

Indexed keywords

BILE ACID; CHENODEOXYCHOLIC ACID; CHOLIC ACID; DEOXYCHOLIC ACID; MICROCRYSTALLINE CELLULOSE; PLACEBO; URSODEOXYCHOLIC ACID; CHOLAGOGUE;

ADULT; ARTICLE; CANCER PREVENTION; CLINICAL ARTICLE; CLINICAL TRIAL; COLON CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; CYTOLYSIS; CYTOTOXICITY; DOUBLE BLIND PROCEDURE; FECES ANALYSIS; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTESTINE EPITHELIUM CELL; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; WATER CONTENT; CHEMISTRY; COLORECTAL TUMOR; FECES; GAS CHROMATOGRAPHY; HEMOLYSIS; MIDDLE AGED; ORAL DRUG ADMINISTRATION; REFERENCE VALUE; RISK FACTOR;

ADMINISTRATION, ORAL; ADULT; BILE ACIDS AND SALTS; CHOLAGOGUES AND CHOLERETICS; CHROMATOGRAPHY, GAS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLORECTAL NEOPLASMS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FECES; FEMALE; HEMOLYSIS; HUMAN; MALE; MIDDLE AGE; REFERENCE VALUES; RISK FACTORS; SUPPORT, NON-U.S. GOV'T; URSODEOXYCHOLIC ACID; HUMANS; MIDDLE AGED;

EID: 0036668696     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.1080/003655202760230955     Document Type: Article

References (44)

1. Cancer statistics 1997
2. Chemoprevention of colorectal tumors: Role of lactulose and of other agents
3. Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis: A review
4. Ursodeoxycholic acid for primary biliary cirrhosis
5. Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: A placebo-controlled trial
6. Chemoprevention of azoxymethane-induced colonic carcinogenesis by supplemental dietary ursodeoxycholic acid
7. Effects of calcium and bile acid feeding on colon tumors in the rat
8. 7β-dehydroxylation of ursodeoxycholic acid by whole cells and cell extracts of the intestinal anaerobic bacterium Eubacterium species V.P.I. 12708
9. Cell type-dependent effect of phospholipid and cholesterol on bile salt cytotoxicity
10. Calcium ameliorates the toxic effect of deoxycholic acid on colonic epithelium
11. Diet-induced increase of colonic bile acids stimulates lytic activity of fecal water and proliferation of colon cells
12. Acute and chronic effect of dietary cholic acid on colonic epithelial cell proliferation
13. Stimulation of deoxythymidine incorporation in the colon of rats treated intrarectally with bile acids and fats
14. Faecal steroid composition and its relationship to cancer of the large bowel
15. Steroids and cancer: Faecal bile acid screening for early detection of cancer risk
16. Fecal bile acid profiles of Japanese patients with adenomatous polyps of the large bowel: Special reference to distribution, multiplicity, size and degree of dysplasia of the polyps
17. Increased serum deoxycholic acid levels in men with colorectal adenomas
18. Effect of molecular structure on bile acid-induced alterations in absorptive function, permeability and morphology in the perfused rat colon
19. Influence of hydroxylation and conjugation of bile salts on their membrane-damaging properties: Studies on isolated hepatocytes and lipid membrane vesicles
20. Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts: In vivo studies in the rat
21. Calcium in milk products precipitates intestinal fatty acids and secondary bile acids and thus inhibits colonic cytotoxicity in humans
22. Cellular toxicity of fecal water depends on diet
23. Lytic effects of mixed micelles of fatty acids and bile acids
24. Dietary calcium phosphate inhibits cytotoxicity of fecal water
25. Increased cell division as a cause of human cancer
26. Changes in rectal epithelial cell proliferation and intestinal bile acids after subtotal colectomy in familial adenomatous polyposis
27. Mechanisms of the protective effect of supplemental dietary calcium on cytolytic activity of fecal water
28. Serum bile acid analysis
29. Sensitive pulsed amperometric detection of free conjugated bile acids in combination with gradient reversed-phase HPLC
30. Evaluation of ileal function using 23-selena-25homotaurocholate, a-labeled conjugated bile acid; initial clinical assessment
31. 75Se-homocholic acid taurine
32. Acute effects of ursodeoxycholic and chenodeoxycholic acid on the small intestinal absorption of bile acids
33. Ileal excretion of bile acids: Comparison with biliary bile composition and effect of ursodeoxycholic acid treatment
34. The site-specific delivery of ursodeoxycholic acid to the rat colon by sulfate conjugation
35. Changes in biliary lipid and biliary bile acid composition in patients after administration of ursodeoxycholic acid
36. Ursodeoxycholic acid treatment in humans: Effects on plasma and biliary lipid metabolism with special reference to very low density lipoprotein triglyceride and bile acid kinetics
37. Urinary excretion of bile acids during acute administration in man
38. Tauroursodeoxycholate increases rat liver ursodeoxycholate levels and limits lithocholate formation better than ursodeoxycholate
39. Differing effects of ursodeoxycholic or chenodeoxycholic acid on biliary cholesterol saturation and bile acid metabolism in man, a dose-response study
40. Enrichment of the more hydrophilic bile acid ursodeoxycholic acid in the fecal water-soluble fraction after feeding to rats with colon polyps
41. Ursodeoxycholate reduces hepatotoxicity of bile salts in primary human hepatocytes
42. Toxicity of bile acids to colon cancer cell lines
43. Prolonged administration of bile salts for gallstone dissolution and its effects on rectal epithelial cell proliferation
44. Differences in the metabolism and disposition of ursodeoxycholic acid and of its taurine-conjugated species in patients with primary biliary cirrhosis