Inhibitory effect of roxithromycin on the local levels of bone-resorbing cytokines in an experimental model of murine osteomyelitis

Journal of Antimicrobial Chemotherapy

Volumn 50, Issue 2, 2002, Pages 289-292

  Yoshii, Takashi ^a,b   Magara, Shinya ^b   Miyai, Daisuke ^b   Kuroki, Eiji ^b   Nishimura, Hidetaka ^b   Furudoi, Shungo ^b   Komori, Takahide ^b  

^a Department of Dentistry   (Japan)

^b KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; ROXITHROMYCIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACTERIAL COUNT; BONE LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL INFECTION; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; OSTEOLYSIS; OSTEOMYELITIS; PROTEIN EXPRESSION; STAPHYLOCOCCUS AUREUS; STATISTICAL SIGNIFICANCE; ANIMAL; DISEASE MODEL; DRUG ANTAGONISM; DRUG SCREENING; FEMALE; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; METHODOLOGY; PATHOLOGY; STAPHYLOCOCCUS INFECTION; TIBIA;

ANIMALS; BONE RESORPTION; CYTOKINES; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; FEMALE; MICE; MICE, INBRED ICR; OSTEOMYELITIS; ROXITHROMYCIN; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; TIBIA;

EID: 0036668120     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkf124     Document Type: Article

References (10)

1. Anti-inflammatory activity of macrolides: A new therapeutic potential?
2. Suppressive activity of a macrolide antibiotic, roxithromycin, on pro-inflammatory cytokine production in vitro and in vivo
3. Effects of roxithromycin on proliferation of peripheral blood mononuclear cells and production of lipopolysaccharide-induced cytokines
4. Antiasthmatic activity of a macrolide antibiotic, roxithromycin: Analysis of possible mechanisms in vitro and in vivo
5. Anti-inflammatory activity of macrolide antibiotics
6. Local and systemic inflammatory mediator release in patients with acute and chronic posttraumatic osteomyelitis
7. Effect of combination therapy of rifampicin and azithromycin on TNF levels during a rat model of chronic osteomyelitis
8. A study on experimental pyogenic osteomyelitis. Especially the production of experimental osteomyelitis in mice
9. Intraphagocytic penetration of macrolide antibiotics
10. Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin