Is the synonymous substitution rate in mammals gene-specific? [3]

Molecular Biology and Evolution

Volumn 19, Issue 8, 2002, Pages 1395-1398

  Williams, Elizabeth J B ^a   Hurst, Laurence D ^a  

^a University of Bath   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; EVOLUTION; GENE CONVERSION; GENETIC SELECTION; GENETIC VARIABILITY; HUMAN; LETTER; MUTATION; NONHUMAN; ANIMAL; BIOLOGICAL MODEL; CODON; DNA BASE COMPOSITION; GENE; GENETICS; MAMMAL; MOLECULAR EVOLUTION; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE;

MAMMALIA;

ANIMALS; BASE COMPOSITION; BASE SEQUENCE; CODON; EVOLUTION, MOLECULAR; GENES; HUMANS; MAMMALS; MODELS, GENETIC; MOLECULAR SEQUENCE DATA;

EID: 0036667703     PISSN: 07374038     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.molbev.a004202     Document Type: Letter

References (22)

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3. Rates of nucleotide substitution and mammalian nuclear gene evolution: Approximate and maximum-likelihood methods lead to different conclusions
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5. Selection on silent sites in the rodent H3 histone gene family
6. An analysis of codon usage in mammals: Selection or mutation bias?
7. Codon-based model of nucleotide substitution for protein-coding DNA sequences
8. Sex biases in the mutation rate
9. Covariation of GC content and the silent site substitution rate in rodents: Implications for methodology and for the evolution of isochores
10. What drives codon choices in human genes
11. A simple method for estimating evolutionary rates of base subsititutions through comparative studies of nucleotide sequences
12. Mutation rates in mammalian genomes
13. Unbiased estimation of the rates of synonymous and nonsynonymous substitution
14. A new method for estimating synonymous and non-synonymous rates of nucleotide substitution considering the relative likelihood of nucleotide and codon changes
15. Frequencies of synonymous substitutions in mammals are gene-specific and correlated with frequencies of nonsynonymous substitutions
16. The importance of base composition in the correct assessment of genetic distance
17. Sensitivity of patterns of molecular evolution to alterations in methodology: A critique of Hughes and Yeager
18. Estimation of the number of nucleotide substitutions in the control region of mitochondrial-DNA in humans and chimpanzees
19. Codon usage bias covaries with expression breadth and the rate of synonymous evolution in humans, but this is not evidence for selection
20. The molecular evolution of signal peptides
21. Mammalian gene evolution: Nucleotide sequence divergence between mouse and rat
22. Estimating synonymous and nonsynonymous substitution rates under realistic evolutionary models