Neuronal density and architecture (Gray Level Index) in the brains of autistic patients

Journal of Child Neurology

Volumn 17, Issue 7, 2002, Pages 515-521

  Casanova, Manuel F ^a   Buxhoeveden, Daniel P ^a   Switala, Andrew E ^a   Roy, Emil ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; AUTISM; AUTOPSY; BRAIN CORTEX; BRAIN NERVE CELL; BRAIN REGION; CELL COUNT; CELL DENSITY; CHILD; CONTROLLED STUDY; CYTOARCHITECTURE; FEMALE; HUMAN; HUMAN CELL; MALE; MULTIVARIATE ANALYSIS; NISSL STAINING; PRIORITY JOURNAL;

EID: 0036657409     PISSN: 08830738     EISSN: None     Source Type: Journal    
DOI: 10.1177/088307380201700708     Document Type: Article

References (90)

1. Kanner L: Autistic disturbances of affective contact. Nerv Child 1943;2:217-250.
2. Bailey A, Phillips W, Rutter M: Autism: Toward an integration of clinical, genetic, neuropsychological, and neurobiological perspectives. J Child Psychol Psychiatry 1996;37:39-126.
3. Lotspeich LJ, Ciaranello RD: The neurobiology and genetics of infantile autism. Int Rev Neurobiol 1993;35:87-128.
4. McGuffin P, Owen MJ, O'Donovan MC, et al: Seminars in Psychiatric Genetics. London, The Royal College of Psychiatrists, 1994.
5. Bauman ML: Microscopic neuroanatomic abnormalities in autism. Pediatrics 1991;87:791-796.
6. Bauman ML, Kemper TL: Histoanatomic observations of the brain in early infantile autism. Neurology 1985;35:866-874.
7. Bauman ML, Kemper TL: Neuroanatomic observations of the brain in autism, in Bauman ML, Kemper TL (eds): The Neurobiology of Autism. Baltimore, The Johns Hopkins University Press, 1996, 119-145.
8. Bauman ML, Kemper TL: The Neurobiology of Autism. Baltimore, The Johns Hopkins University Press, 1996.
9. Kemper TL, Bauman ML: Neuropathology of infantile autism. J Neuropathol Exp Neurol 1998;57:645-652.
10. Raymond GV, Bauman ML, Kemper TL: Hippocampus in autism: A Golgi analysis. Acta Neuropathol 1996;91:117-119.
11. Bailey A, Luther P, Dean A, et al: A clinicopathological study of autism. Brain 1998;121:889-905.
12. Bailey A, Luthert P, Bolton P: Autism and megalencephaly. Lancet 1993;341:1225-1226.
13. Coleman PD, Romano J, Lapham L, Simon W. Cell counts in cerebral cortex of an autistic patient. J Autism Dev Dis 1985;15: 245-255.
14. Ritvo ER, Freeman, BJ, Scheibel AB: Lower Purkinje cell counts in the cerebella of four autistic subjects: Initial findings of the UCLA-NSAC autopsy research report. Am J Psychiatry 1986;143: 862-866.
15. Rodier PM, Ingram JL, Tisdale B: Embryological origin for autism: Developmental anomalies of the cranial nerve motor nuclei. J Comp Neurol 1996;370:247-261.
16. Williams RS, Hauser SL, Purpura DP: Autism and mental retardation: Neuropathological studies performed in four retarded persons with autistic behavior. Arch Neurol 1980;37:749-753.
17. Casanova MF, Buxhoeveden D, Switala A, Roy E: Minicolumnar pathology in autism. Neurology 2001;58:428-432.
18. Schlaug G, Schleicher A, Zilles K: Quantitative analysis of the columnar arrangement of neurons in the human cingulate cortex. J Comp Neurol 1995;351:441-452.
19. Schleicher A, Zilles K, Wree A: A quantitative approach to cytoarchitectonics: Software and hardware aspects of a system for evaluation and analysis of structural inhomogeneities in nervous tissue. J Neurosci Meth 1986;18:221-235.
20. Amunts K, Schmidt-Passos F, Schleicher A, Zilles K: Postnatal development of interhemispheric asymmetry in the cytoarchitecture of human area 4. Anat Embryol (Berl) 1997;196:393-402.
21. Rehkamper G, Zilles K, Schleicher A: A quantitative approach to cytoarchitectonics IX: The areal pattern of the hyperstriatum ventrale in the domestic pigeon Columna liva f.d. Anat Embryol (Berl) 1984;169:319-327.
22. Sauer B: Quantitative analysis of the laminae of the striate area compared with automatically-obtained grey level index profiles. J Hirnforsch 1983;24:79-87.
23. Sauer B: Quantitative analysis of the laminae of the striate area on man: An application of automatic image analysis. J Hirnforsch 1983;24:89-97.
24. Sauer B: Semi-automatic analysis of microscopic images of the human cerebral cortex using the grey level index. J Microsc 1983; 129:75-87.
25. Schleicher A, Zilles K: A quantitative approach to cytoarchitectonics: Analysis of structural inhomogeneities in nervous tissue using an image analyzer. J Microsc 1990;157:367-381.
26. Schleicher A, Amunts K, Geyer S, et al: Observer-independent method for microstructural parcellation of cerebral cortex: A quantitative approach to cytoarchitectonics. Neuroimage 1999;9: 165-177.
27. Wree A, Zilles K, Schleicher A: A quantitative approach to cytoarchitectonics VII: The areal pattern of the cortex of the guinea pig. Anat Embryol (Berl) 1981;162:81-103.
28. Wree A, Schleicher A, Zilles K: Estimation of volume fractions in nervous tissue with an image analyzer. J Neurosci Meth 1982;6: 29-43.
29. Wree A, Zilles K, Schleicher A: A quantitative approach to cytoarchitectonics VIII: The areal pattern of the cortex of the albino mouse. Anat Embryol (Berl) 1983;166:333-353.
30. Zilles K, Schleicher A, Kretschmann HJ: Automatic morphometric analysis of retrograde changes in the nucleus n. facialis at different ontogenetic stages in the rat. Cell Tissue Res 1978;190: 285-299.
31. Zilles K, Zilles B, Schleicher A: A quantitative approach to cytoarchitectonics VI: The areal pattern of the cortex of the albino rat. Anat Embryol (Berl) 1980;159:335-360.
32. Zilles K, Armstrong E, Schlaug G, Schleicher A: Quantitative cytoarchitectonics of the posterior cingulate cortex in primates. J Comp Neurol 1986;253:514-524.
33. Dekaban AS, Sadowsky D: Changes in brain weights during the span of human life: Relation of brain weights to body heights and body weights. Ann Neurol 1978;4:345-356.
34. Rakic P: Defects of neuronal migration and the pathogenesis of cortical malformations. Prog Brain Res 1988;73:15-37.
35. Rakic P: One small step for the cell, a giant leap for mankind: A hypothesis of neocortical expansion during evolution. Trends Neurosci 1995;18:383-388.
36. Rakic P, Kornack DR: Neocortical expansion and elaboration during primate evolution: A view from neuroembryology, in Falk D, Gibson KR (eds): Evolutionary Anatomy of the Primate Cerebral Cortex. Cambridge, UK, Cambridge University Press, 2001, 30-56.
37. Buxhoeveden DP, Lefkowitz W, Loats P, Armstrong E: The linear organization of cell columns in human and nonhuman anthropoid Tpt cortex. Anat Embryol (Berl) 1996;194:23-36.
38. Favorov OV, Diamond ME: Demonstration of discrete place-defined columns-segregates-in the cat SI. J Comp Neurol 1990;298: 97-112.
39. Kaas JH, Nelson RJ, Sur M, Merzenich MM: Organization of somatosensory cortex in primates, in Schmitt FO, Worden FG, Adelman G, Dennis SG (eds): The Organization of the Cerebral Cortex. Cambridge, MA, MIT Press, 1981, 237-261.
40. Mountcastle VB: The columnar organization of the neocortex. Brain 1997;120:701-722.
41. Ong WY, Carey LJ: Neuronal architecture of the human temporal cortex. Anat Embryol (Berl) 1990;181:351-369.
42. Rakic P: Neurons in rhesus monkey visual cortex: Systematic relation between time of origin and eventual disposition. Science 1974;183:425-427.
43. Rakic P, Sidman RL: Supervital DNA synthesis in the developing human and mouse brain. J Neuropathol Exp Neurol 1968;27: 246-276.
44. Afifi AK, Bergman RA: Functional Neuroanatomy: Text and Atlas. New York, McGraw-Hill, 1998.
45. Rapin I: Autism. N Engl J Med 1997;337:97-104.
46. Davidovitch M, Patterson B, Gartside P: Head circumference measurements in children with autism. J Child Neurol 1996;11: 389-393.
47. Rapin I: Neurological examination, in Rapin I (ed): Preschool Children with Inadequate Communication: Developmental Language with Inadequate Communication: Developmental Language Disorder, Autism, Low IQ. London, MacKeith Press, 1996, 98-122.
48. Steg JP, Rapoport JL: Minor physical anomalies in normal, neuronic learning disabled and severely disturbed children. J Autism Child Schizophr 1975;5:299-307.
49. Walker HA: Incidence of minor physical anomaly in autism. J Aut Child Schiz 1977;7:165-176.
50. Woodhouse W, Bailey A, Rutter M, et al: Head circumference in autism and other pervasive developmental disorders. J Child Psychol Psychiatry 1996;37:665-671.
51. Friedman L, Wiechers IR, Cerny CA: If patients with schizophrenia have small brains, why don't they have small heads? Schizophr Res 2000;42:1-6.
52. Filipek P, Richelne C, Kennedy DN, et al: Morphometric analysis of the brain in developmental language disorders and autism. Ann Neurol 1992;32:475.
53. Courchesne E, Muller RA, Saitoh O: Brain weight in autism: Normal in the majority of cases, megaloencephalic in rare cases. Neurology 1999;52:1057-1059.
54. Courchesne E, Karns CM, Davis HR, et al: Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study. Neurology 2001;57:245-254.
55. Fombonne E, Roge B, Claverie J, et al: Microcephaly and macrocephaly in autism. J Autism Dev Disord 1999;29:113-119.
56. Piven J, Arndt S, Bailey J, et al: An MRI study of brain size in autism. Am J Psychiatry 1995;152:1145-1149.
57. Piven J, Arndt S, Bailey J, Andreasen N: Regional brain enlargement in autism: A magnetic resonance imaging study. J Am Acad Child Adolesc Psychiatry 1996;35:530-536.
58. Lainhart JE, Piven J, Wzorek M, et al: Macrocephaly in children and adults with autism. J Am Acad Child Adolesc Psychiatry 1997; 36:282-290.
59. Gibson KR, Rumbaugh D, Beran M: Bigger is better: Primate brain size in relationship to cognition, in Falk D, Gibson KR (eds): Evolutionary Anatomy of the Primate Cerebral Cortex. Cambridge, UK, Cambridge University Press, 2001, 79-97.
60. Blinkov SM, Glezer II: The Human Brain in Figures and Tables. A Quantitative Handbook. New York, Basic Books, 1968, 184.
61. Deacon TW: Rethinking mammalian brain evolution. Am Zoologist 1990;30:629-705.
62. Ringo JL: Neuronal interconnection as a function of brain size. Brain Behav Evol 1991;38:1-6.
63. Holman MA: Brain evolution in hominids: Are we at the end of the road? in Falk D, Gibson KR (eds): Evolutionary Anatomy of the Primate Cerebral Cortex. Cambridge, UK, Cambridge University Press, 2001, 113-127.
64. Hofman MA: On the evolution and geometry of the brain in mammals. Prog Neurobiol 1989;32:137-158.
65. Cody AH, Keyes-Elstein L, Piven J: Gray and White Matter Volume on MRI in Autism. Presented at the International Meeting for Autism Research, San Diego, 2001.
66. Herbert MR, Steele S, Adrien K, et al: Large Brains With Increased White Matter Volume in Two Groups of Autistic Boys. Presented at the International Meeting for Autism Research, San Diego, 2001.
67. Gibson KR, Rumbaugh D, Beran M: Bigger is better: Primate brain size in relationship to cognition, in Falk D, Gibson KR (eds): Evolutionary Anatomy of the Primate Cerebral Cortex. Cambridge, UK, Cambridge University Press, 2001, 79-97.
68. Allman J: Evolution of the visual system in the early primates, in Sprague JM, Epstein AN (eds): Progress in Psychology and Physiological Psychology. New York, Academic Press, 1977, 1-53.
69. Allman J: Evolution of neocortex, in Jones EG, Peters A (eds): Cerebral Cortex. Volume B: Comparative Structure and Evolution of Cerebral Cortex, Part II. New York, Plenum, 1990, 269-283.
70. Kaas JH: The organization and evolution of neocortex, in Wise SP (ed): Higher Brain Function: Recent Explorations of the Brain's Emergent Properties. New York, John Wiley, 1987, 347-378.
71. Kaas JH: The evolution of isocortex. Brain Behav Evol 1995;46:187-196.
72. Favorov OV, Kelly G: Minicolumnar organization within somatosensory cortical segregates I: Development of afferent connections. Cereb Cortex 1994;4:408-427.
73. Favorov OV, Kelly G: Minicolumnar organization within somatosensory cortical segregates II: Emergent functional properties. Cereb Cortex 1994;4:428-442.
74. Favorov OV, Whitsel BL: Spatial organization of the peripheral input to area 1 cell columns I: The detection of 'segregates'. Brain Res Rev 1988;13:25-42.
75. Favorov OV, Whitsel BL: Spatial organization of the peripheral input to area 1 cell columns II: The forelimb representation achieved by mosaic of segregates. Brain Res Rev 1988;13:43-56.
76. Tommerdahl M, Favorov O, Whitsel BL, et al: Minicolumnar activation patterns in cat and monkey S1 cortex. Cereb Cortex 1993;3: 399-411.
77. Volkmar FR, Nelson DS: Seizure disorders in autism. J Am Acad Child Adolesc Psychiatry 1995;29:127-129.
78. Olsson I, Steffenburg S, Gillberg C: Epilepsy in autism and autisticlike conditions: A population-based study. Arch Neurol 1988;45: 666-668.
79. Childs JA, Blair JL: Valproic acid treatment of epilepsy in autistic twins. J Neurosci Nurs 1997;29:244-248.
80. Jambaque I, Chiron C, Dumas C, et al: Mental and behavioural outcome of infantile epilepsy treated by vigabatrin in tuberous sclerosis patients. Epilepsy Res 2000;38:151-160.
81. Plioplys AV. Autism: Electroencephalogram abnormalities and clinical improvement with valproic acid. Arch Pediatr Adolesc Med 1994;148:220-222.
82. Uvebrant P, Bauziene R: Intractable epilepsy in children. The efficacy of lamotrigine treatment, including non-seizure-related benefits. Neuropediatrics 1994;25:284-289.
83. Hollander E, Dolgoff-Kaspar R, Cartwright C, et al: An open trial of divalproex sodium in autism spectrum disorders. J Clin Psychiatry 2001;62:530-534.
84. DeFelipe J: Chandelier cells and epilepsy. Brain 1999;122:1807-1822.
85. Hirsch JC, Agassandian C, Merchan-Perez A, et al: Deficit of quantal release of GABA in experimental models of temporal lobe epilepsy. Nat Neurosci 1999;2:499-500.
86. Marco P, DeFelipe J: Altered synaptic activity in the human temporal neocortex removed from epileptic patients. Exp Brain Res 1997;114:1-10.
87. DeFelipe J, Hendry S, Jones EG: Visualization of chandelier cell axons by parvalbumin immunoreactivity in monkey cerebral cortex. Proc Natl Acad Sci USA 1989;503:49-54.
88. DeFelipe J, Hendry S, Hashikawa T, et al: A microcolumnar structure of monkey cerebral cortex revealed by immunocytochemical studies of double bouquet cell axons. Neuroscience 1990;37: 655-673.
89. Lund JS, Yoshioka T, Levitt JB: Comparison of intrinsic connectivity in different areas of macaque monkey cerebral cortex. Cereb Cortex 1993;3:148-162.
90. Marin-Padilla M: Prenatal and early postnatal ontogenesis of the human motor cortex: A Golgi study. II. The Basket-pyramidal system. Brain Res 1970;23:185-191.