2-Bromopropane induces DNA damage, impairs functional antioxidant cellular defenses, and enhances the lipid peroxidation process in primary cultures of rat Leydig cells

Reproductive Toxicology

Volumn 16, Issue 4, 2002, Pages 379-384

  Wu, Xiangdong ^a,b,d   Faqi, Ali S ^a,c   Yang, Jianming ^b   Pang, Bing ^b   Ding, Xuncheng ^b   Jiang, Xuezhi ^b   Chahoud, Ibrahim ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b Natl Eval Ctr Toxicol Fertil R   (China)

^c IIT RESEARCH INSTITUTE   (United States)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

2 Bromopropane; Comet cells; DNA damage; Leydig cells; Lipid peroxidation

Indexed keywords

2 BROMOPROPANE; 2-BROMOPROPANE; ANTIOXIDANT; BROMINATED HYDROCARBON; CHORIONIC GONADOTROPIN; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; MUTAGENIC AGENT; REACTIVE OXYGEN METABOLITE; SCAVENGER; SUPEROXIDE DISMUTASE; TESTOSTERONE;

ANIMAL; ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL CULTURE; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVITY; LEYDIG CELL; LIPID PEROXIDATION; MALE; METABOLISM; NONHUMAN; OXIDATIVE STRESS; RAT; REPRODUCTIVE TOXICITY; TESTOSTERONE RELEASE;

ANIMALS; ANTIOXIDANTS; CELLS, CULTURED; COMET ASSAY; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FREE RADICAL SCAVENGERS; GLUTATHIONE PEROXIDASE; HYDROCARBONS, BROMINATED; LEYDIG CELLS; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; MUTAGENS; RATS; SUPEROXIDE DISMUTASE;

ANIMALIA;

EID: 0036655313     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0890-6238(02)00039-4     Document Type: Article

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