Growth-promoting activity of pyrazinoic acid, a putative active compound of antituberculosis drug pyrazinamide, in niacin-deficient rats through the inhibition of acmsd activity

Bioscience, Biotechnology and Biochemistry

Volumn 66, Issue 7, 2002, Pages 1435-1441

  Fukuwatari, Tsutomu ^a   Sugimoto, Etsuro ^a   Shibata, Katsumi ^a  

^a UNIVERSITY OF SHIGA PREFECTURE   (Japan)

Author keywords

Nicotinamide; Pyrazinamide; Pyrazinoic acid; Tryptophan metabolism; Tryptophan niacin conversion ratio

Indexed keywords

POA;

AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE; AMINOCARBOXYMUCONATE-SEMIALDEHYDE DECARBOXYLASE; CARBOXYLYASE; DRUG DERIVATIVE; KYNURENIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINIC ACID; PYRAZINAMIDE; PYRAZINOIC ACID; TRYPTOPHAN; TUBERCULOSTATIC AGENT; XANTHURENIC ACID;

ANIMAL; ARTICLE; DIET; DRUG ANTAGONISM; DRUG EFFECT; EATING; ENZYMOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; KIDNEY; LIVER; MALE; METABOLISM; RAT; URINE; WEIGHT GAIN; WISTAR RAT;

ANIMALS; ANTITUBERCULAR AGENTS; CARBOXY-LYASES; DIET; EATING; INJECTIONS, INTRAPERITONEAL; KIDNEY; KYNURENIC ACID; LIVER; MALE; NAD; NIACIN; PYRAZINAMIDE; RATS; RATS, WISTAR; TRYPTOPHAN; WEIGHT GAIN; XANTHURENATES;

EID: 0036653397     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.66.1435     Document Type: Article

References (36)

1. McKenzie, D., Malone, S., Kushner, S., Oleson, J. J., and Subbarow, Y., The effect of nicotinic acid on experimental tuberculosis of white mice. J. Lab. Clin. Med., 33, 1249-1253 (1948).
2. World Health Organization, WHO report on the tuberculosis epidemic; stop TB at the source. Tuberculosis Program, World Health Organization, Geneva, Switzerland, 1995.
3. Konno, K., Feldmann, F. M., and McDermott, W., Pyrazinamide susceptibility and amidase activity of tubercle bacilli. Am. Rev. Respir. Dis., 95, 461-469 (1967).
4. Trivedi, S. S. and Desai, S. G., Pyrazinamidase activity of Mycobacterium tuberculosis-a test sensitivity to pyrazinamide. Tubercle, 68, 221-224 (1987).
5. Scorpio, A. and Zhang, Y., Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus. Nat. Med., 2, 662-667 (1996).
6. Scorpio, A., Lindholm-Levy, P., Heifets, L., Gilman, R., Siddiqi, S., Cynamon, M., and Zhang, Y., Characterization of pncA mutations in pyrazinamide-resistant Mycobacterirum tuberculosis. Antimicrob. Agents Chemother., 41, 540-543 (1997).
7. McCune, R. M., Tompsett, R., and McDermott, W., The fate of Mycobacterium tuberculosis in mouse tissues as determined by the microbial enumeration technique. J. Exp. Med., 104, 763-802 (1956).
8. Tarshis, M. S. and Weed, W. A., Lack of significant in vitro sensitivity of Mycobacterium tuberculosis to pyrazinamide on three solid media. Am. Rev. Tuberc, 67, 391-395 (1953).
9. Shibata, K., Effects of dietary pyrazinamide on the growth of weaning rats fed with a nicotinic acid-free and tryptophan-limited diet. Agric. Biol. Chem., 55, 3111-3112 (1991).
10. Shibata, K., Effects of pyrazinamide on tryptophanniacin conversion in rats. Agric. Biol. Chem., 54, 2463-2464 (1990).
11. Shibata, K., Fukuwatari, T., and Sugimoto, E., Effects of dietary pyrazinamide, an antituberculosis agent, on the metabolism of tryptophan to niacin and of tryptophan to serotonin in rats. Biosci. Biotechnol. Biochem., 65, 1339-1346 (2001).
12. Hayakawa, T., Shibata, K., and Iwai, K., Purification and some properties of nicotinate phos-phoribosyltransferase from hog liver. Agric. Biol. Chem., 48, 445-453 (1984).
13. Nasu S., Yamaguchi, K., Sakakibara, S., Imai, H., and Ueda, I., The effect of pyrazines on the metabolism of tryptophan and nicotinamide adenine dinucleotide in the rat. Evidence of the formation of a potent inhibitor of aminocarboxymuconate-semialde-hyde decarboxylase from pyrazinamide. Biochim. Biophys. Acta, 677, 109-119 (1981).
14. 1-methylnicotinamide. J. Biol. Chem., 206, 121-127 (1954).
15. 1-methyl-3-pyridone-4-carboxamide, by high-performance liquid chromatography. J. Chro-matogr., 424, 23-28 (1988).
16. Shibata, K. and Murata, K., Blood NAD as an index of niacin nutrition. Nutr. Int., 2, 177-181 (1986).
17. Shibata, K., The metabolism of niacin in each organ and the biological method for assessing the nutritional status of niacin in the rat. Vitamins (Japan), 61, 39-56 (1987).
18. Shibata, K. and Tanaka, K., Simple measurement of blood NADP and blood levels of NAD and NADP in humans. Agric. Biol. Chem., 50, 2941-2942 (1986).
19. 1-methyl-nicotinamide in urine by high-performance liquid chromatography. Vitamins, 61, 599-604 (1987).
20. Shibata, K., Fluorimetric micro-determination of kynurenic acid, an endogenous blocker of neurotoxicity, by high-performance liquid chromatography. J. Chromatogr., 430, 376-380 (1988).
21. Shibata, K. and Onodera, M., Simultaneous highperformance liquid chromatographic measurement of xanthurenic acid and 3-hydroxyanthranilic acid in urine. Biosci. Biotechnol. Biochem., 56, 974 (1992).
22. Ichiyama, A., Nakamura, S., Kawai, H., Honjo, T., Nishizuka, Y., Hayaishi, O., and Senoh, T., Studies on the benzene ring of tryptophan in mammalian tissues. II. Enzymic formation of a-aminomuconic acid from 3-hydroxyanthranilic acid. J. Biol. Chem., 240, 740-749 (1965).
23. Shibata, K., Fukuwatari, T., and Sugimoto, E., Reversed phase HPLC of nicotinic acid mononucleotide for measurement of quinolinate phos-phoribosyltransferase. J. Chromatogr., 749, 281-285 (2000).
24. Shibata, K. and Matsuo, H., Changes in blood NAD and NADP levels, and the urinary excretion of nicotinamide and its metabolites in women students after nicotinamide administration. Vitamins (Japan), 64, 301-306 (1989).
25. Ikeda, M., Tsuji, H., Nakamura, S., Ichiyama, A., Nishizuka, Y., and Hayaishi, O., Studies on the biosynthesis of nicotinamide adenine dinucleotide. II. A role of picolinic carboxylase in the biosynthesis of nicotinamide adenine dinucleotide from tryptophan in mammals. J. Biol. Chem., 240, 1395-1401 (1965).
26. Hayaishi, O., Studies on the biosynthesis of NAD from tryptophan. Vitamins (Japan), 31, 107-114 (1965).
27. Ghafoorunissa, G. and Rao, B. S., Effect of protein level in the diet on quinolinate phosphoribosyltransferase of rat liver. Life Sci., 15, 1597-1602 (1974).
28. Sanada, H., Alteration of tryptophan-niacin metabolism by hormones and nutrients. Vitamins (Japan), 61, 549-562 (1987).
29. Shibata, K. and Toda, S., Effect of thyroxine on the conversion ratio of tryptophan to nicotinamide in rats. Biosci. Biotechnol. Biochem., 58, 1757-1762 (1994).
30. Shibata, K., Effects of protein-amino acids, lipid, and carbohydrate on the conversion ratio of tryptophan to niacin. Vitamins (Japan), 70, 369-382 (1996).
31. Fukuwatari, T., Morikawa, Y., Hayakawa, F., Sugimoto, E., and Shibata K., Influence of adenine-induced renal failure on tryptophan-niacin metabolism in rats. Biosci. Biotechnol. Biochem., 65, 2154-2161 (2001).
32. Shin, M., Iwamoto, N., Yamashita, M., Sano, K., and Umezawa, C., Pyridine nucleotide levels in liver of rats fed clofibrate- or pyrazinamide-containing diets. Biochem. Pharmacol., 55, 367-371 (1998).
33. Zimhony, O., Cox, J. S., Welch, J. T., Vilcheze, C., and Jacobs, W. R., Jr., Pyrazinamide inhibits the eukaryotic-like fatty acid synthetase I (FASI) of Mycobacterium tuberculosis. Nat. Med., 6, 1043-1047 (2000).
34. Bloch, K., Fatty acid synthases from Mycobacterium phlei. Methods Enzymol., 35, 84-90 (1975).
35. Brennan, P. J. and Nikaido, H., The envelope of mycobacteria. Annu. Rev. Biochem., 64, 29-63 (1995).
36. Vesell, E. S. and Beyer, K. H., Jr., Studies on pyrazinoylguanidine. 7. Effects of single oral doses in normal human subjects. Pharmacology, 58,140-146 (1999).