The actin-severing activity of cofilin is exerted by the interplay of three distinct sites on cofilin and essential for cell viability

Biochemical Journal

Volumn 365, Issue 1, 2002, Pages 147-155

  Moriyama, Kenji ^a   Yahara, Ichiro ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Actin binding protein; Cell motility; Cell survival; Cytoskeleton; Destrin

Indexed keywords

ACCELERATION; DEPOLYMERIZATION; MOLECULAR DYNAMICS; MONOMERS;

COFILLIN;

CELLS;

ACTIN BINDING PROTEIN; COFILIN; F ACTIN; PHALLOIDIN;

ACTIN FILAMENT; ARTICLE; BINDING KINETICS; CELL GROWTH; CELL MOTILITY; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DEPOLYMERIZATION; ENDOCYTOSIS; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; TURNOVER TIME;

ACTIN DEPOLYMERIZING FACTORS; ACTINS; ANIMALS; BINDING SITES; CELL SURVIVAL; MICROFILAMENT PROTEINS; MODELS, MOLECULAR; MUTATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SWINE;

MAMMALIA; SUIDAE;

EID: 0036646059     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020231     Document Type: Article

References (37)

1. r actin-binding and depolymerizing protein
2. Cofilin is an essential component of the yeast cortical cytoskeleton
3. The Caenorhabditis elegans unc-6O gene encodes proteins homologous to a family of actin-binding proteins
4. Identification, characterization, and intracellular distribution of cofilin in Dictyostelium discoideum
5. Mutations in twinstar, a Drosophila gene encoding a cofilin/ADF homologue, result in defects in centrosome migration and cytokinesis
6. Xenopus laevis actin-depolymerizing factor/cofilin: A phosphorylation-regulated protein essential for development
7. Overexpression of cofilin stimulates bundling of actin filaments, membrane ruffling, and cell movement in Dictyostelium
8. Actin depolymerizing factor (ADF/cofilin) enhances the rate of filament turnover: Implication in actin-based motility
9. Xenopus actin depolymerizing factor/cofilin (XAC) is responsible for the turnover of actin filaments in Listeria monocytogenes tails
10. Cofilin promotes rapid actin filament turnover in vivo
11. Cofilin is a component of intranuclear and cytoplasmic actin rods induced in cultured cells
12. Cofilin, a protein in porcine brain that binds to actin filaments and inhibits their interactions with myosin and tropomyosin
13. pH control of actin polymerization by cofilin
14. Isolation and characterization of a regulated form of actin depolymerizing factor
15. Phosphorylation of Ser-3 of cofilin regulates its essential function on actin
16. Inhibition of the interactions of cofilin, destrin, and deoxyribonuclease I with actin by phosphoinositides
17. Cofilin changes the twist of F-actin: Implications for actin filament dynamics and cellular function
18. ADF/cofilin weakens lateral contacts in the actin filament
19. Two activities of cofilin, severing and accelerating directional depolymerization of actin filaments, are affected differentially by mutations around the actin-binding helix
20. Human CAP1 is a key factor in the recycling of cofilin and actin for rapid actin turnover
21. Actin depolymerizing factor stabilizes an existing state of F-actin and can change the tilt of F-actin subunits
22. The second ADF/cofilin actin-binding site exists in F-actin, the cofilin-G-actin complex, but not in G-actin
23. Live dynamics of Dictyostelium cofilin suggests a role in remodeling actin latticework into bundles
24. Essential functions and actin-binding surfaces of yeast cofilin revealed by systematic mutagenesis
25. Uncoupling actin filament fragmentation by cofilin from increased subunit turnover
26. The C-terminal tail of UNC-60B (actin depolymerizing factor/cofilin) is critical for maintaining its stable association with F-actin and is implicated in the second actin-binding site
27. Tertiary structure of destrin and structural similarity between two actin-regulating protein families
28. Structure determination of yeast cofilin
29. Crystal structure of the actin-binding protein actophorin from Acanthamoeba
30. End-label fingerprintings show that an N-terminal segment of depactin participates in interaction with actin
31. Cofilin and gelsolin segment-1: Molecular dynamics simulation and biochemical analysis predict a similar actin binding mode
32. Refinement of the F-actin model against X-ray fiber diffraction data by the use of a directed mutation algorithm
33. New actin mutants allow further characterization of the nucleotide binding cleft and drug binding sites
34. The identification of a second cofilin binding site on actin suggests a novel, intercalated arrangement of F-actin binding
35. Fluorimetry study of N-(1-pyrenyl) iodoacetamide-labelled F-actin. Local structural change of actin protomer both on polymerization and on binding of heavy meromyosin
36. 6-etheno-ATP with actin-bound nucleotides as a tool for studying the steady-state exchange of subunits in F-actin solutions
37. Inhibition of actin polymerization by a synthetic dodecapeptide patterned on the sequence around the actin-binding site of cofilin