The road ended up at stem cells

Immunological Reviews

Volumn 185, Issue , 2002, Pages 159-174

  Weissman, Irving L ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD38 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANTIGEN PRESENTATION; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL ISOLATION; CELLULAR IMMUNITY; GRAFT REJECTION; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL; HISTOCOMPATIBILITY; HUMAN; HUMAN CELL; IMMUNOASSAY; IMMUNOREACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROGENY; REVIEW; STEM CELL; T LYMPHOCYTE;

ALLERGY AND IMMUNOLOGY; ANIMALS; BRAIN; CELL DIFFERENTIATION; HEMATOPOIETIC STEM CELLS; HISTOCOMPATIBILITY; HISTORY, 20TH CENTURY; HUMANS; IMMUNITY, CELLULAR; NEOPLASMS; STEM CELLS;

EID: 0036630988     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-065X.2002.18514.x     Document Type: Review

References (183)

1. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells
2. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells
3. The distribution of colony-forming cells among spleen colonies
4. Immunogenetic consequences of vascular anastomoses between bovine twins
5. Cytological evidence for a relationship between normal hematopoietic colony-forming cells and cells of the lymphoid system
6. Physical separation of hematopoietic stem cells from cells forming colonies in culture
7. Physical separation of hematopoietic stem cells differing in their capacity for self-renewal
8. Structural identify of the pluripotential hemopoietic stem cell
9. Physical separation of hematopoietic stem cells differing in their capacity for self-renewal
10. Continuous cultures of fused cells secreting antibody of predefined specificity
11. Cell sorting: Automated separation of mammalian cells as a function of intracellular fluorescence
12. Fetal hematopoietic origins of the adult hematolymphoid system
13. An in vivo assay for thymus-homing bone marrow cells
14. Characteristics of thymus-homing bone marrow cells
15. Bone marrow cells give rise to distinct cell clones within the thymus
16. lo hematopoietic stem cell
17. Purification and characterization of mouse hematopoietic stem cells
18. Clonal analysis of hematopoietic stem-cell differentiation in vivo
19. Resistance of various inbred strains of mice to tumor homoiotransplants, and its relation to the H-2 allele which each carries
20. A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells
21. The genetics of transplantation
22. Actively acquired tolerance
23. Quantitative studies on tissue transplantation immunity. II. The origin, strength and duration of actively and adoptively acquired immunity
24. Actively acquired tolerance
25. Quantitative studies on tissue transplantation immunity. IV. Induction of tolerance in newborn mice and studies on the phenomenon of runt disease
26. 'Secondary disease' of radiation chimeras: A syndrome due to lymphoid aplasia
27. Mortality and skin transplantability in x-irradiated mice receiving isologous, homologous, or heterologous bone marrow
28. 1 hybrid effect
29. Immunological aspects of homo- and hetero-logous bone marrow transplantation in irradiated animals
30. Immunogenetic consequences of vascular anastomoses between bovine twins
31. Sex-linked rejection of normal and neoplastic tissue. I. Distribution and specificity
32. Attempts to demonstrate sex-linked histocompatibility genes
33. The Stanford plan. An educational continuum for medicine
34. The demise of the five-year plan
35. Immunological tolerance and immunological paralysis
36. Passive transfer of transplantation immunity
37. Genes and antibodies
38. Tolerance of skin induced by erythrocytes in poultry
39. Antibody formation and repressor systems
40. The molecular basis of antibody formation
41. Immunological function of the thymus
42. Comparative susceptibility of lymphoid tissues of strain C57 Black mice to induction of lymphoid tumors by irradiation
43. Preliminary studies of the effectiveness of local irradiation in the induction of lymphoid tumors in mice
44. Leukemogenic activity of filtrates from radiation-induced lymphoid tumors of mice
45. Lymphoid tumor induction by mouse thymocytes infected in vitro with radiation leukemia virus
46. The radical radiotherapy of regionally localized Hodgkin's disease
47. Evidence for a tumoricidal dose level in the radiotherapy of Hodgkin's disease
48. The Stanford medical linear accelerator. I. Design and development
49. Extended-field radical radiotherapy in advanced Hodgkin's disease, short-term results of 2 randomized clinical trials
50. Fifth tissue homotransplantation conference
51. Specific 'conditioning' of the host. Section VIII. Tissue transplantation
52. Role of the thymus in transplantation immunity
53. The effect of the continuous reinfusion of lymph and lymphocytes on the output of lymphocytes from the thoracic duct of unanaesthetized rats
54. The life-history of the lymphocytes
55. The recirculation of lymphocytes from blood to lymph in the rat
56. The migration of lymphocytes into lymphoid tissue
57. The route of recirculation of lymphocytes in the rat
58. Inhibition of immune responses by small lymphocytes
59. The migration of lymphocytes through the endothelium of venules in lymph nodes: An electron microscope study
60. Transfer of tolerance
61. Studies on the mechanism of split tolerance in mice
62. Age effect on thymus graft regeneration and immunologic restoration of thymectomized hosts
63. The effect of millipore filter pore size on immunological restoration of thymectomized hosts
64. Studies on the rate of seeding of lymphocytes from the intact guinea pig thymus
65. Thymus cell migration
66. Thymus-dependent areas in the B lymphoid organs of neonatally thymectomized mice
67. The thymus and the precursors of antigen-reactive cells
68. Immunological activity of thymus and thoracic duct lymphocytes
69. Cell to cell interaction in the immune response. I. Hemolysinforming cells in neonatally thymectomized mice reconstituted with thymus or thoracic duct lymphocytes
70. Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes
71. The bone marrow origin of lymphoid primary follicle small lymphocytes
72. Lymphoid tissue architecture, experimental analysis of the origin and distribution of T-cells and B-cells
73. Homing properties of thymus-independent follicular lymphocytes
74. Dual origin of intimal cells in cardiac-allograft arteriosclerosis
75. Tissue localization of lymphoid cells
76. Mouse lymph node germinal centers contain a selected subset of T cells - The helper phenotype
77. 131I-labelled flagella in lymph nodes
78. Antigens in immunity. XV. Ultrastructural features of antigen capture in primary and secondary lymphoid follicles
79. Lymphocyte homing into lymph nodes in vitro demonstration of the selective affinity of recirculating lymphocytes for high endothehal venules
80. Lymphocyte adherence to high endothelial venules: Characterization of a modified in vitro assay, and examination of the binding of syngeneic and allogeneic lymphocyte populations
81. Organ specificity of lymphocyte migration: Mediation by highly selective lymphocyte interaction with organ-specific determinants on high endothelial venules
82. Differences in the migration of B and T lymphocytes, organ-selective localization in vivo and the role of lymphocyte-endothelial cell recognition
83. A cell-surface molecule involved in organ-specific homing of lymphocytes
84. Mouse lymph node homing receptor cDNA clone encodes a glycoprotein revealing tandem interaction domains
85. The mouse lymph node homing receptor is identical with the lymphocyte cell surface marker Ly-22: Role of the EGF domain in endothelial binding
86. Human homologue of mouse lymph node homing receptor: Evolutionary conservation at tandem cell interaction domains
87. Identification of a murine Peyer's patch-specific lymphocyte homing receptor as an integrin molecule with a β chain homologous to human VLA-4β
88. Peyer's patch-specific lymphocyte homing receptors consist of a VLA-4-like α chain associated with either of two integrin β chains, one of which is novel
89. Cloning and expression of cDNAs for the α subunit of the murine lymphocyte-Peyer's patch adhesion molecule
90. Cloning and expression of mouse integrin βρ(β7): A functional role in Peyer's patch-specific lymphocyte homing
91. Germinal center B cells lack homing receptors necessary for normal lymphocyte recirculation
92. The in vivo behavior of T cell clones: Altered migration due to loss of the lymphocyte surface homing receptor
93. Identification of a I07-kD glycoprotein that mediates adhesion between stromal cells and hematolyphoid cells
94. Evidence for a role of the integrin VLA-4 in lympho-hemotopoiesis
95. Role of cell adhesion molecules in the development of insulin-dependent diabetes melletis. Implications for pathogenesis and therapy
96. 4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment
97. High endothelial venule binding as a predictor of the dissemination of passaged murine lymphomas
98. L-selectin can facilitate metastasis to lymph nodes in a transgenic mice model of carcinogenesis
99. Expression of the integrin α4β1 on melanoma cells can inhibit the invasive stage of metastasis formation
100. + hematopoietic stem cells following mobilization by cyclophosphamide/granulocyte-colony stimulating factor
101. A monoclonal antibody that recognizes B cells and B cell precursors in mice
102. B220: A B cell-specific member of the T200 glycoprotein family
103. Lymphoid tissue architecture. II. Ontogeny of peripheral T and B cells in mice: Evidence against Peyer's patches as the site of generation of B cells
104. Development and distribution of immunoglobulin-bearing cells in mice
105. Long-term culture of B lymphocytes and their precursors from murine bone marrow
106. Bone marrow stromal cells with lymphopoietic activity express high levels of a pre-B neoplasia-associated molecule
107. Isolation of murine pluripotent hematopoietic stem cells
108. lo bone marrow cells repopulate the thymus
109. Mature T cells generated from single thymic clones are phenotypically and functionally heterogeneous
110. The stem cell antigens Sca-1 and Sca-2 subdivide thymic and peripheral T lymphocytes into unique subsets
111. Two monoclonal antibodies identify thymic-repopulating cells in mouse bone marrow
112. An attempt to produce 'pre-T' cell hybridomas and to identify their antigens
113. Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family
114. + cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow
115. Evidence that hematopoietic stem cells express mouse c-kit, but do not depend on steel factor for their generation
116. Characterization of a population of cells in the bone marrow that phenotypically mimics hematopoietic stem cells: Resting stem cells or mystery population?
117. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype
118. Flk-2 a marker in hematopoietic stem cell differentiation: A simple method to isolate long-term stem cells
119. Telomerase activity in HSC is associated with self-renewal potential
120. - hematolymphoid cells
121. The aging of hematopoietic stem cells
122. Identification of a lineage of multipotent hematopoietic progenitors
123. Transplantation of purified hematopoietic stem cells: Requirements for overcoming the barriers of allogeneic engraftment
124. Tolerance of allogeneic heart grafts in mice simultaneously reconstituted with purified allogeneic hematopoietic stem cells
125. Purified hematopoietic stem cell grafts induce tolerance to alloantigens and can mediate positive and negative T cell selection
126. Isolation and characterization of hematopoietic progenitor and stem cells
127. Stem cells: Units of development, units of regeneration, and units in evolution. Invited review
128. Translating stem and progenitor cell biology to the clinic, barriers and opportunities. Invited review
129. Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiation
130. Towards regenerative medicine
131. The SCID-hu mouse, murine model for the analysis of human hematolymphoid differentiation and function
132. Infection of the SCID-hu mouse by HIV-1
133. The SCID-hu mouse: Current status and potential applications
134. The SCID-hu mouse: A small animal model for HIV infection and pathogenesis
135. + precursor cells
136. Isolation of a candidate human hematopoietic stem cell population
137. Isolation and characterization of hematopoietic progenitor and stem cells
138. Phenotypic and functional analysis of hematopoietic stem cells in mouse and human
139. + hematopoietic stem cells in patients with metastatic breast cancer
140. + hematopoietic stem cells in patients with recurrent indolent non-Hodgkin's lymphoma
141. + hematopoietic stem cells (HSCs) in multiple myeloma: Impact of HSC dose on engraftment, safety, and immune reconstitution
142. High doses of purified stem cells cause early hematopoietic recovery in syngeneic and allogeneic hosts
143. Proliferation, differentiation, and long-term culture of primary hippocampal neurons
144. Stem cells in the central nervous system
145. A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes
146. Is there a neural stem cell in the mammalian forebrain?
147. In vitro expansion of a multipotent population of human neural progenitor cells
148. Direct isolation of human central nervous system stem cells
149. Site specific migration and neuronal differentiation of human neural progenitor cells after transplantation in the adult rat brain
150. Isolation of a stem cel for neurons and glia from the mammalian neural crest
151. Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells
152. Identification of clonogenic common lymphoid progenitor in mouse bone marrow
153. An alternate pathway for T cell development supported by the bone marrow microenvironment: Recapitulation of thymic maturation
154. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
155. The c-kit positive maturation pathway in mouse thymic T cell development: Lineages and selection
156. Two distinct pathways of positive selection for thymocytes
157. + cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells
158. Dendritic cell potentials of early lymphoid and myeloid progenitors
159. Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia
160. BCL-2 cooperates with Promyelocytic Leukemia Retinoic Acid Receptor (PMLRARα) to block neutrophil differentiation and initiate acute leukemia
161. AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations
162. AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation
163. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
164. Stem cells, cancer, and cancer stem cells
165. Physiological migration of hematopoietic stem and progenitor cells
166. Thymus cell maturation: Studies on the origin of cortisone-resistant thymic lymphocytes
167. Thymus cell maturation. II. Differentiation of three 'mature' subclasses in vivo
168. Lymphoid development from stem cells and the common lymphocyte progenitors
169. In vitro cortisone sensitivity of in vivo cortisone-resistant thymocytes
170. A homing receptor-bearing cortical thymocyte subset: Implications for thymus cell migration and the nature of cortisone-resistant thymocytes
171. Self recognition in colonial marine forms and flowering plants in relation to the evolution of immunity
172. Colony specificity in compound ascidians as tested by fusion experiments
173. Protochordate allorecognition is controlled by an MHC-like gene system
174. Colony specificity in the colonial tunicate Botryllus and the origins of vertebrate immunity
175. A cyclical, developmentally-regulated death phenomenon in a colonial urochordate
176. Somatic and germ cell parasitism in a colonial ascidian: Possible role for a highly polymorphic allorecognition system
177. Heritable germ and somatic cell lineage competitions in chimeric colonial protochordates