Osteoclast function is regulated by neighbouring osteoblasts: Osteoprotegerin, RANK, and RANK ligand constitute a unique regulatory system for bone resorption with important pathophysiological and therapeutic aspects;Osteoklastfunktionen reguleres af naboosteoblaster: Osteoprotegerin, RANK og RANK-ligand udgør et unikt regulatorisk system for knogleresorptionen med betydelige patofysiologiske og behandlingsmœssige aspekter

Ugeskrift for Laeger

Volumn 164, Issue 27, 2002, Pages 3526-3530

  Ueland, Thor ^a   Bollerslev, Jens ^a   Mosekilde, Leif ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIGAND; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; CARRIER PROTEIN; GLYCOPROTEIN;

BONE DISEASE; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; DRUG INDUCED DISEASE; HUMAN; HUMAN CELL; HYPERCALCEMIA; MACROPHAGE; MUTATION; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; PAGET BONE DISEASE; PATHOPHYSIOLOGY; POSTMENOPAUSE; REGULATORY MECHANISM; REVIEW; RHEUMATOID ARTHRITIS; STROMA CELL; BONE REMODELING; FEMALE; GENETICS; MALE; METABOLISM; PHYSIOLOGY; POSTMENOPAUSE OSTEOPOROSIS;

BONE REMODELING; BONE RESORPTION; CARRIER PROTEINS; CELL SURVIVAL; FEMALE; GLYCOPROTEINS; HUMANS; MALE; OSTEOBLASTS; OSTEOCLASTS; OSTEOPOROSIS, POSTMENOPAUSAL; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 0036628606     PISSN: 00415782     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (23)

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2. Thickness of bone formed at remodeling sites in normal human iliac trabecular bone: Variations with age and sex
3. The actions of parathyroid hormone on bone: Relation to bone remodeling and turnover, calcium homeostasis, and metabolic bone disease. Part I of IV parts: Mechanisms of calcium transfer between blood and bone and their basis: Morphological and kinetic approaches to bone turnover
4. The structural relationship of bone forming and endothelial cells of the bone marrow
5. Cancellous bone remodeling occurs in specialized compartments lined by cells expressing osteoblastic markers
6. The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption
7. Osteoprotegerin and its ligand: A new paradigm for regulation of osteoclastgenesis and bone resorption
8. Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
9. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
10. The role of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in the pathogenesis and treatment of metabolic bone diseases
11. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
12. RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis
13. The expression of osteoprotegerin and RANK ligand and the support of osteoclast formation by stromal-osteoblast lineage cells is developmental regulated
14. Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis
15. Paget's disease of bone
16. Heritable disorders of connective tissue
17. Familial Paget's disease of bone: Patterns of inheritance and frequency of linkage to chromosome 18q
18. Evaluation of the role of Rank and OPG genes in Paget's disease of bone
19. Osteoclast differentiation from circulating mononuclear precursor is Paget's disease is hypersensitive to 1,25-dihydroxyvitamin D(3) and RANKL
20. Enhanced RANK ligand expression and responsivity of bone marrow cells in Paget's disease of bone
21. Parathyroid hormone stimulates TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures: Correlation with osteoclast-like celle formation
22. Osteoclast differentiation factor mediates an essential for bone resumption induced by 1 alpha-25-dihydroxyvitamin D, Prostaglandin E2, or parathyroid hormone in the microenvironment of bone
23. The effect of a single dose of osteoprotegerin in postmenopausal women