Central hyperexcitability in chronic musculoskeletal pain: A conceptual breakthrough with multiple clinical implications

Pain Research and Management

Volumn 7, Issue 2, 2002, Pages 81-92

  Lidbeck, Jan ^a  

^a Pain Management Clinic   (Sweden)

Author keywords

Central sensitization; Chronic musculoskeletal pain; Mechanism based pain classification; Pain modulation

Indexed keywords

ADRENALIN; AMITRIPTYLINE; ANALGESIC AGENT; DEXTROMETHORPHAN; KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NORADRENALIN UPTAKE INHIBITOR; OPIATE; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

CENTRAL NERVOUS SYSTEM FUNCTION; CHRONIC PAIN; CLINICAL PRACTICE; CLINICAL PROTOCOL; DRUG EFFICACY; EXCITABILITY; FIBROMYALGIA; HUMAN; LOW BACK PAIN; MEDICAL RESEARCH; MEDICOLEGAL ASPECT; MYALGIA; MYOFASCIAL PAIN; NECK PAIN; NOCICEPTION; OCCUPATIONAL DISEASE; PAIN THRESHOLD; PATHOGENESIS; PATHOPHYSIOLOGY; REHABILITATION MEDICINE; REVIEW; SENSITIZATION; SHOULDER PAIN; WHIPLASH INJURY;

EID: 0036618998     PISSN: 12036765     EISSN: None     Source Type: Journal    
DOI: 10.1155/2002/310974     Document Type: Review

References (129)

1. The dorsal horn: State-dependent sensory processing, plasticity and the generation of pain
2. Peripheral neuronal mechanisms of nociception
3. Mechanisms of neuropathic pain
4. Wind-up and the NMDA receptor complex from a clinical perspective
5. Multiple mechanisms of neuropathic pain: A clinical perspective
6. Unmasking mechanisms of peripheral neuropathic pain in a clinical perspective
7. Pharmacology of pain transmission and control
8. In search of the pathogenesis of refractory cervicobrachial pain syndrome
9. Sensitization: A neurobiological theory for muscle pain
10. Muscle activity and chronic muscle pain
11. Non-nociceptive aspects of persistent musculoskeletal pain
12. Neurobiologische grundlagen von muskelschmerz
13. Pain mechanism in myogenous temporomandibular disorders
14. Chronic pain in society - A case for chronic pain as a dysfunctional state?
15. Wind-up and central sensitization are not equivalent
16. Windup leads to characteristics of central sensitization
17. Ketamin reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients
18. Abnormalities of somatosensory perception in patients with painful osteoarthritis normalize following successful treatment
19. Progressive tactile hypersensitivity: An inflammation-induced incremental increase in the excitability of the spinal cord
20. Neuronal plasticity: Increasing the gain in pain
21. Basic issues in the psychobiology of pain
22. Extensive reorganization of primary somatosensory cortex in chronic back pain patients
23. Towards a model of pathophysiology of fibromyalgia: Aberrant central pain mechanisms with peripheral modulation
24. Fibromyalgia syndrome: A problem of tautology
25. Neuroclinical pathogenesis of fibromyalgia syndrome
26. Referred pain and hyperalgesia related to muscle and visceral pain
27. Differential diagnosis of muscular and neuropathic pain supported by quantitative sensory testing
28. Injection of hypertonic saline into musculus infraspinatus resulted in referred pain and sensory disturbances in the ipsilateral upper arm
29. Nonorganic physical signs in low back pain
30. Abnormal sensitization and temporal summation of second pain (wind-up) in patients with fibromyalgia syndrome
31. Genetic factors influence the development of mechanical hypersensitivity, motor deficits and morphological damage after transient cord ischemia in the rat
32. Pain due to trauma including sports injuries
33. Developmental neurobiology of pain
34. Classification of chronic pain at a multidisciplinary pain rehabilitation clinic
35. The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic and receptor activation; Implications for the treatment of post-injury pain hypersensitivity states
36. Posttraumatic headache
37. Uncontrolled pain following physical injury as the core-trauma in post-traumatic stress disorder
38. Post-traumatic stress disorder in chronic pain patients
39. Prolonged functional impairments after whiplash injury
40. Whiplash injury
41. The prevalence of chronic cervical zygapophysial joint pain after whiplash
42. Generalised muscular hyperalgesia in chronic whiplash syndrome
43. Allodynia and psychological profile in chronic whiplash patients
44. Is pain following whiplash injury associated with central nervous system hypersensitivity?
45. Myofascial pain and whiplash
46. Some observation on whiplash injuries
47. Response to treatment for pectoralis minor myofascial pain syndrome after whiplash
48. Increased rates of fibromyalgia following cervical spine injury. A controlled study of 161 cases of traumatic injury
49. Musculoskeletal injury as a trigger for fibromyalgia/posttraumatic fibromyalgia
50. Regional cervicobrachial pain: Correlation of psychophysical findings and clinical features
51. Neurobiological mechanisms underlying chronic whiplash associated pain: The peripheral maintenance of central sensitization
52. Clinical and etiological update of myofascial pain from trigger points
53. Muscle but not cutaneous C-afferent input produces prolonged increases in the excitability of the flexon reflex in the rat
54. Hyperalgesia in response to injury to cutaneous and deep tissues
55. Changes in the functional organization of the dorsal horn during acute myositis and following muscle nerve axotomy
56. Biochemical pathogenesis of myofascial pain
57. Contribution of central neuroplasticity to pathological pain: Review of clinical and experimental evidence
58. Psychophysical evidence for a neuropathic component of chronic neck pain
59. Arthralgia and myalgia
60. Quantitatively altered nociception in chronic myofascial pain
61. Clinical update on other pain syndromes
62. Mechanisms of spontaneous tension-type headaches: An analysis of tenderness, pain threshold and EMG
63. Generalized vibrotactile allodynia in a patient with temporomandibular disorder
64. Brainstem mechanisms underlying temporomandibular joint and masticatory muscle pain
65. Low back pain: Current physiologic concepts
66. Pain analysis. A study in patients with chronic low back pain or fibromyalgia
67. Evidence for the role of psychological factors in abnormal paraspinal activity in patients with chronic low back pain
68. Pain sensitivity as a correlate of clinical status in individuals with chronic low back pain
69. Spine update. Spinal pain mechanisms
70. The effects of normal, frozen, and hyaluronidase-digested nucleus pulposus on nerve root structure and function
71. Herniated lumbar disc material as a source of free glutamate available to affect pain signals through the dorsal root ganglion
72. Central hyper-excitability in fibromyalgia
73. Neuroendocrine deficiency-mediated development and persistence of pain in fibromyalgia: A promising paradigm?
74. Modulatory influence on somatosensory perception from vibration and heterotopic noxious stimulation (HNCS) in fibromyalgia patients and healthy subjects
75. Possible deficiencies of pain modulation in fibromyalgia
76. Evidence of qualitatively altered nociception in patients with fibromyalgia
77. Sensory dysfunction in fibromyalgia patients with implications for pathogenic mechanisms
78. Elevated CSF levels of substance P and high incidence of Raynauds phenomenon in patients with fibromyalgia: New features for diagnosis
79. Endogenous opioid peptides, substance P, calcitonin gene-related peptide and their relation to fibromyalgia
80. Chronic cervical zygapophysial joint pain after whiplash. A placebo-controlled prevalence study
81. Multi-method assessment of experimental and clinical pain in patients with fibromyalgia
82. Pain and psychological medicine
83. Pain beliefs and the use of cognitive-behavioural coping strategies
84. Intensive, dynamic back-muscle exercises, conventional physiotherapy, or placebo-controlled treatment of low-back pain
85. Factors associated with early discharge from a multi-disciplinary work rehabilitation program for chronic low back pain
86. A trial of modern rehabilitation of chronic low back pain and disability. Vocational outcome and effect of pain modulation
87. Outcome of a multimodal treatment inducing intensive physical training of patients with chronic low back pain
88. Intensive physical and psychosocial training program for patients with chronic low back pain
89. The role of psychological factors in chronic pain. I. A half century of study
90. The role of psychological factors in chronic pain. II. A critical appraisal
91. Spine update. Behavioral responses to examination. A reappraisal of the interpretation of 'nonorganic signs'
92. Back pain in the workplace
93. Pain as a four letter word
94. Back pain, psychology and money
95. Back pain: Bankrupt expertise and new directions
96. Chronic pain disability in the workplace
97. Neuromodulation: Advancing the pain paradigm for the next millenium
98. The denial of chronic pain
99. Pain analysis in prediction of treatment outcome
100. Pharmacological tests in pain analysis and in prediction of treatment outcome
101. Towards a mechanism-based classification of pain?
102. Implications of recent advances in the understanding of pain pathophysiology for the assessment of pain in patients
103. Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain
104. Antidepressants in neuropathic pain
105. The clinical features of the fibromyalgia syndrome
106. Tricyclic antidepressants block NMDA-receptor mediated synaptic responses and induction of long-term potentiation in rat hippocampal slices
107. The N-methyl-D-aspartate receptor antagonist dextrometorphan selectively reduces temporal summation of second pain in man
108. Effect of systemic N-methyl-D-aspartate receptor antagonist (dextromethorphan) on primary and secondary hyperalgesia in humans
109. Effect of ketamin, an NMDA receptor inhibitor, in acute and chronic orofacial pain
110. Effect of NMDA receptor antagonism with ketamin and magnesium chloride in chronic neuropathic pain
111. Novel pharmacological targets in the treatment of pain
112. N-methyl-D-aspartate receptors in pain
113. Distribution of reduced nicotinamide-adenine-dinucleotide-phosphate diaphorasepositive cells and fibres in the cat central nervous system
114. The NO-cGMP pathway in neonatal rat dorsal horn
115. Possible mechanism of action of nitric oxide inhibitors in chronic myofascial pain
116. Effect of inhibition of nitric oxide synthase on chronic tension-type headache: A randomised crossover trial
117. Sensitization, somatisation, and subjective health complaints
118. Chronic widespread pain and the fibromyalgia construct
119. Out-patient cognitive-behavioural treatment of fibromyalgia: Impact on pain response and health status
120. Group treatment of fibromyalgia: A 6 month outpatient program
121. Outcome from the Skogli fibromyalgia treatment program
122. Interdisciplinary treatment for fibromyalgia syndrome: Clinical and statistical significance