Genome annotation techniques: New approaches and challenges

Drug Discovery Today

Volumn 7, Issue 11, 2002, Pages

  Rust, Alistair G ^a   Mongin, Emmanuel ^a   Birney, Ewan ^a  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOINFORMATICS; COMPUTER PROGRAM; DATA BASE; DNA SEQUENCE; GENE MAPPING; GENE SEQUENCE; GENOME ANALYSIS; HUMAN; HUMAN GENOME; INFORMATION PROCESSING; NONHUMAN; PREDICTION; PROTEIN DOMAIN; PROTEIN STRUCTURE; REVIEW;

COMPUTATIONAL BIOLOGY; DATABASES, GENETIC; GENOME, HUMAN; HUMANS; MOLECULAR SEQUENCE ANNOTATION;

EID: 0036606878     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(02)02289-4     Document Type: Review

References (36)

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2. The sequence of the human genome
3. Genomes online database (GOLD): A monitor of genome projects worldwide
4. Drug discovery of the future: The implications of the human genome project
5. Annotating eukaryote genomes
6. Using bioinformatics in gene and drug discovery
7. The Ensembl genome database project
8. The Celera Discovery System
9. Basic local alignment search tool
10. RefSeq and LocusLink: NCBI gene-centered resources
11. The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000
12. The EMBL nucleotide sequence database
13. GenBank
14. Prediction of complete gene structures in human genomic DNA
15. Identification of human gene structure using linear discriminant functions and dynamic programming
16. Automated gene identification in large-scale genomic sequences
17. Dynamite: A flexible code generating language for dynamic programming methods used in sequence comparison
18. EST_GENOME: A program to align spliced DNA sequences to unspliced genomic DNA
19. A computer program for aligning a cDNA sequence with a genomic DNA sequence
20. Genew: The human gene nomenclature database
21. The Pfam protein families database
22. PRINTS and PRINTS-S shed light on protein ancestry
23. The PROSITE database, its status in 2002
24. ProDom and ProDom-CG: Tools for protein domain analysis and whole genome comparisons
25. Blocks+: A non-redundant database of protein alignment blocks derived from multiple compilations
26. SMART: A web-based tool for the study of genetically mobile domains
27. InterPro - An integrated documentation resource for protein families, domains and functional sites
28. Gene ontology: Tool for the unification of biology
29. Open annotation offers a democratic solution to genome sequencing
30. The distributed annotation system
31. Data warehousing in molecular biology
32. Progress in sequencing the mouse genome
33. Noncoding RNA gene detection using comparative sequence analysis
34. VISTA: Visualizing global DNA sequence alignments of arbitrary length
35. Long-range comparisons of human and mouse SCL loci: Localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequences
36. Minimum information about a microarray experiment (MIAME) - Toward standards for microarray data