Phosphorylation-dependent interaction of the synaptic vesicle proteins cysteine string protein and synaptotagmin I

Biochemical Journal

Volumn 364, Issue 2, 2002, Pages 343-347

  Evans, Gareth J O ^a   Morgan, Alan ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Exocytosis; Hsc70; Protein kinase A; Protein phosphorylation

Indexed keywords

BIOASSAY; BIOLOGICAL MEMBRANES; BRAIN; IMMUNOLOGY; PROTEINS;

BINDING ASSAYS;

BIOCHEMISTRY;

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYSTEINE STRING PROTEIN; RECOMBINANT PROTEIN; SYNAPTOTAGMIN;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN MEMBRANE; COMPLEX FORMATION; CONTROLLED STUDY; EXOCYTOSIS; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; SYNAPSE VESICLE; WESTERN BLOTTING;

ANIMALS; CALCIUM-BINDING PROTEINS; HSP40 HEAT-SHOCK PROTEINS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; NERVE TISSUE PROTEINS; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN BINDING; RATS; SYNAPSES; SYNAPTOTAGMIN I; SYNAPTOTAGMINS;

ANIMALIA;

EID: 0036606587     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020123     Document Type: Article

References (39)

1. A cysteine-string protein is expressed in retina and brain of Drosophila
2. The cysteine-string domain of the secretory vesicle cysteine string protein is required for membrane targeting
3. The cysteine string secretory vesicle protein activates Hsc70 ATPase
4. Activation of the ATPase activity of heat-shock proteins Hsc70/Hsp70 by cysteine string protein
5. Mutational analysis of cysteine-string protein function in insulin
6. The molecular chaperone function of the secretory vesicle cysteine string proteins
7. A trimeric protein complex functions as a synaptic chaperone machine
8. Cysteine-string protein: The chaperone at the synapse
9. Molecular chaperones and the regulation of neurotransmitter exocytosis
10. Overexpression of cysteine-string proteins in Drosophila reveals interactions with syntaxin
11. Cysteine-string protein increases the calcium sensitivity of neurotransmitter exocytosis in Drosophila
12. Comparison of cysteine string protein (csp) and mutant α-SNAP overexpression reveals a role for csp in late steps of membrane fusion in dense-core granule exocytosis in adrenal chromaffin cells
13. Phosphorylation of cysteine string protein by protein kinase A: Implications for the modulation of exocytosis
14. The synaptic vesicle protein, cysteine-string protein, is associated with the plasma membrane in 3T3-L1 adipocytes and interacts with syntaxin 4
15. Drosophila Hsc70-4 is critical for neurotransmitter exocytosis in vivo
16. Cysteine string protein regulates G protein modulation of N-type calcium channels
17. 2+ channels
18. Interaction of cysteine string proteins with the α1A subunit of the P/Q-type calcium channel
19. Suppression cloning of the cDNA for a candidate subunit of a presynaptic calcium channel
20. Synaptotagmin I functions as a calcium regulator of release probability
21. 2+ and assembly with the core SNARE complex onto membranes
22. Cysteine string proteins are associated with chromaffin granules
23. Calcium-dependent interaction of the cytoplasmic region of synaptotagmin with membranes. Autonomous function of a single C2-homologous domain
24. A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion
25. Modulation of neurotransmitter release by dihydropyridine-sensitive calcium channels involves tyrosine phosphorylation
26. 2+ regulates the interaction between synaptotagmin and syntaxin 1
27. Isoform-specific, calcium-regulated interaction of the synaptic vesicle proteins SV2 and synaptotagmin
28. A novel function for the second C2 domain of synaptotagmin: Calcium-triggered dimerization
29. 2+ sensor for transmitter release at a central synapse
30. Syntaxin 1A interacts with multiple exocytic proteins to regulate neurotransmitter release in vivo
31. Mutational analysis of Drosophila synaptotagmin demonstrates its role in calcium-activated neurotransmitter release
32. Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin
33. Synaptotagmin modulation of fusion pore kinetics in regulated exocytosis of dense core vesicles
34. cAMP modulates exocytotic kinetics and increases quantal size in chromaffin cells
35. Defective recycling of synaptic vesicles in synaptotagmin mutants of Caenorhabditis elegans
36. The products of the Drosophila stoned locus interact with synaptic vesicles via synaptotagmin
37. Synaptotagmin I is a high affinity receptor for clathrin AP-2: Implications for membrane recycling
38. Cysteine string protein is required for calcium secretion coupling of evoked neurotransmission in Drosophila, but not for vesicle recycling
39. Role of auxilin in uncoating clathrin-coated vesicles