Effect of water content on the solid-state stability in two isomorphic clathrates of cephalosporin: Cefazolin sodium pentahydrate (αform) and FK041 hydrate

Chemical and Pharmaceutical Bulletin

Volumn 50, Issue 6, 2002, Pages 766-770

  Mimura, Hisashi ^a   Gato, Katsuhiko ^a   Kitamura, Satoshi ^a   Kitagawa, Teruyuki ^a   Kohda, Shigetaka ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Cefazolin sodium; Cephalosporin; Clathrate; FK041; Solid state stability; Water activity

Indexed keywords

7 [2 (2 AMINO 4 THIAZOLYL) 2 HYDROXYIMINOACETAMIDO] 3 (4 PYRAZOLYLMETHYLTHIO) 3 CEPHEM 4 CARBOXYLIC ACID; CEFAZOLIN; CEPHALOSPORIN; HYDROGEN; ION CHANNEL; WATER; CEPHALOSPORIN DERIVATIVE;

ARTICLE; CRYSTAL STRUCTURE; DRUG DETERMINATION; DRUG STABILITY; HYDRATION; HYDROGEN BOND; PHYSICAL CHEMISTRY; SOLID STATE; WATER CONTENT; CHEMISTRY;

CEFAZOLIN; CEPHALOSPORINS; DRUG STABILITY; WATER;

EID: 0036596481     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.50.766     Document Type: Article

References (13)

1. Kariyone K., Harada H., Kurita M., Takano R., J. Antibiot., 23, 131-136 (1970).
2. Pikal M. J., Lukes A. L., Lang J. E., Gaines K., J. Pharm. Sci., 67, 767-773 (1978).
3. Byrn A. Y., Gray G., Pfeiffer R. R., Frye J., J. Pharm. Sci., 74, 565-568 (1985).
4. Osawa T., Kamat M. S., DeLuca P. P., Pharm. Res., 5, 421-425 (1988).
5. van Meerssche M., Germain M., Declercq J. P., Coene B., Monreaux C., Cryst. Struct. Commun., 8, 287-288 (1979).
6. Stephenson G. A., Diseroad B. A., Int. J. Pharmaceut., 198, 167-177 (2000).
7. Haleblian J. K., J. Pharm. Sci., 64, 1269-1288 (1975).
8. Yamamoto H., Terasawa T., Nakamura A., Kawabata K., Takasugi., Tanaka H., Matsumoto S., Matsumoto Y., Tawara S., Bioorg. Med. Chem., 9, 465-475 (2001).
9. Mimura H., Kitamura S., Kitagawa T., Kohda S., Colloids Surf. B, in press.
10. Zografi G., Drug. Dev. Ind. Pharm., 14, 1905-1926 (1988).
11. Leeson L. J., Mattocks A. M., J. Amer. Pharm. Assoc. Ed., 47, 329-333 (1958).
12. Martin A., "Physical Pharmacy," 4th ed., LEA&FEBIGER, London, 1993, pp. 53-76.
13. Hendriksen B. A., Preston M. S., York P., Int. J. Pharmaceut., 118, 1-10 (1995).