Orally active cephalosporins. Part 3: Synthesis, structure-activity relationships and oral absorption of novel C-3 heteroarylmethylthio cephalosporins

Bioorganic and Medicinal Chemistry

Volumn 9, Issue 2, 2001, Pages 465-475

  Yamamoto, Hirofumi ^a   Terasawa, Takeshi ^a   Nakamura, Ayako ^a   Kawabata, Kohji ^a   Takasugi, Hisashi ^a   Tanaka, Hirokazu ^a   Matsumoto, Satoru ^a   Matsumoto, Yoshimi ^a   Tawara, Shuichi ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

7 [2 (2 AMINO 4 THIAZOLYL) 2 HYDROXYIMINOACETAMIDO] 3 (1 PROPENYL) 3 CEPHEM 4 CARBOXYLIC ACID; 7 [2 (2 AMINO 4 THIAZOLYL) 2 HYDROXYIMINOACETAMIDO] 3 (4 PYRAZOLYLMETHYLTHIO) 3 CEPHEM 4 CARBOXYLIC ACID; 7BETA [2 (2 AMINOTHIAZOL 4 YL) 2 HYDROXYIMINOACETAMIDO] 3 (METHYLTHIO)CEPHALOSPORIN; CEFDINIR; CEFDITOREN PIVOXIL; CEFIXIME; CEPHALOSPORIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG ABSORPTION; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; GRAM NEGATIVE SEPSIS; GRAM POSITIVE BACTERIUM; HAEMOPHILUS INFLUENZAE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; BILE; CEPHALOSPORINS; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HAEMOPHILUS INFLUENZAE; HETEROCYCLIC COMPOUNDS; MICE; MICE, INBRED ICR; MICROBIAL SENSITIVITY TESTS; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; URINE;

HAEMOPHILUS INFLUENZAE; NEGIBACTERIA; POSIBACTERIA;

EID: 0035083302     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00266-2     Document Type: Article

References (12)