Evaluation of odor and sensory irritation thresholds for methyl isobutyl ketone in humans

American Industrial Hygiene Association Journal

Volumn 61, Issue 3, 2000, Pages 340-350

  Dalton, Pamela H ^a   Dilks, Daniel D ^a   Banton, Marcy I ^b  

^a MONELL CHEMICAL SENSES CENTER   (United States)

^b Shell Chemical Co   (United States)

Author keywords

Human; Methyl isobutyl ketone; Odor; Sensory irritation; Thresholds

Indexed keywords

4 METHYL 2 PENTANONE; IRRITANT AGENT;

ADULT; ANNOYANCE; ARTICLE; CHEMICAL ENVIRONMENT; FEMALE; HUMAN; HUMAN EXPERIMENT; INDUSTRIAL HYGIENE; MALE; NORMAL HUMAN; OCCUPATIONAL EXPOSURE; ODOR; OLFACTORY DISCRIMINATION; PERCEPTIVE THRESHOLD;

EID: 0034047502     PISSN: 00028894     EISSN: None     Source Type: Journal    
DOI: 10.1080/15298660008984542     Document Type: Article

References (47)

1. Alarie, Y.: Irritating properties of airborne materials to the upper respiratory tract. Arch. Environ. Health 13:433-449 (1966).
2. Cain, W.S.: Indoor air as a source of annoyance. In Environmental Annoyance: Characterization, Measurement and Control, H.S. Koelega (ed.). Amsterdam: Elsevier, 1987. pp. 189-200.
3. Cain, W.S., L.C. See, and T. Tosun: Irritation and odor from formaldehyde: Chamber studies. ASHRAE Proc. 14:126-137 (1986).
4. American Conference of Governmental Industrial Hygienists (ACGIH): Threshold Limit Values for Chemical Substances and Physical Agents. Cincinnati, Ohio: ACGIH, 1998. pp. 78.
5. Dalton, P., and C.J. Wysocki: The nature and duration of adaptation following long-term exposure to odors. Percep. Psychophys. 58:781-792 (1996).
6. Stevens, J.C., W.S. Cain, F.T. Schiet, and M.W. Oatley: Olfactory adaptation and recovery in old age. Perception 18:265-276 (1989).
7. Matsushita, T., E. Goshima, H. Miyagaki, M. Katsuyoshi, Y. Takeuchi, and T. Inoue: Experimental studies for determining the MAC value of acetone: Biological reactions in the "six-day exposure" to acetone. Japan. J. Ind. Health 11:507-515 (1969).
8. Matsushita, T., A. Yoshumune, T. Inoue, S. Yamada, and H. Suzuki: Experimental studies for determining the MAC value of acetone. 1. Biologic reactions in the one-day exposure to acetone. Japan. J. Ind. Health 11:477-485 (1969).
9. Nelson, K.W., J.F. Ege Jr., and M. Ross: Sensory response to certain industrial solvent vapors. J. Ind. Hyg. Toxicol. 25:282-285 (1943).
10. Cometto-Muñiz, J.E., and W.S. Cain: Thresholds for odor and nasal pungency. Physiol. Behav. 48:719-725 (1990).
11. Doty, R.L.: Intranasal trigeminal detection of chemical vapors by humans. Physiol. Behav. 14:855-859 (1975).
12. Kobal, G., and T. Hummel: Olfactory and intranasal trigeminal event-related potentials in anosmic patients. Laryngoscope 108:1033-1035 (1998).
13. Kendal-Reed, M., and J.C. Walker: Human normosmic and anosmic sensory responses to propionic acid. Chem. Senses 21:622 (1996).
14. Hummel, T., S. Barz, J. Lötsch, S. Roscher, B. Kettenmann, and G. Kobal: Loss of olfactory function leads to a decrease of trigeminal sensitivity. Chem. Senses 21:75-80 (1996).
15. Otto, D.A., H.K. Hudnell, D.E. House, L. Molhave, and W. Counts: Exposure of humans to a volatile organic mixture. I. Behavioral assessment. Arch. Environ. Health 47:23-30 (1992).
16. Hudnell, H.K., D.A. Otto, D.E. House, and L. Molhave: Exposure of humans to a volatile organic mixture. II. Sensory. Arch. Environ. Health 47:31-38 (1992).
17. Seeber, A., R.R. Kiesswetter, M. Vangala, M. Blaszkewicz, and K. Golka: Combined exposure to organic solvents: An experimental approach using acetone and ethyl acetate. Appl. Psychol.: Int. Rev. 41: 281-292 (1992).
18. Wysocki, C.J., P. Dalton, M.J. Brody, and H.J. Lawley: Acetone odor and irritation thresholds obtained from acetone-exposed factory workers and from control (occupationally nonexposed) subjects. Am. Ind. Hyg. Assoc. J. 58:704-712 (1997).
19. Wysocki, C.J., B.G. Green, and T.P. Malia: Monorhinal stimulation as a method for differentiating between thresholds for odor and irritation. Chem. Senses 17:722-723 (1992).
20. Cometto-Muñiz, J.E., and W.S. Cain: Trigeminal and olfactory sensitivity: comparison of modalities and methods of measurement. Int. Arch. Occup. Environ. Health 71:105-110 (1998).
21. Gagnon, P., D. Mergler, and S. Lapare: Olfactory adaptation, threshold shift and recovery at low levels of exposure to methyl isobutyl ketone (MIBK). Neurotoxicology 15:637-642 (1994).
22. Iregren, A., M. Tesarz, and E. Wigaeushjelm: Human experimental MIBK exposure: Effects on heart-rate, performance, and symptoms. Environ. Res. 63:101-108 (1993).
23. Dick, R.B., E.F. Krieg Jr., J. Setzer, and B. Taylor: Neurobehavioral effects from acute exposures to methyl isobutyl ketone and methyl ethyl ketone. Fundam. Appl. Toxicol. 19:453-473 (1992).
24. Hjelm, E.W., M. Hagberg, A. Iregren, and A. Lof: Exposure to methyl isobutyl ketone: Toxicokinetics and occurrence of irritative and CNS symptoms in man. Intl. Arch. Occup. Environ. Health 62:19-26 (1990).
25. Silverman, L., H.F. Schulte, and M.W. First: Further studies on sensory response to certain industrial solvent vapors. J. Ind. Hyg. Toxicol. 28:262-266 (1946).
26. Ruth, J.H.: Odor thresholds and irritation levels of several chemical substances: A review. Am. Ind. Hyg. Assoc. J. 47:142-151 (1986).
27. Cain, W.S., and C. Murphy: Interaction between chemoreceptive modalities of odour and irritation. Nature 284:255-257 (1980).
28. Dalton, P., C.J. Wysocki, M.J. Brody, and H.J. Lawley: The influence of cognitive bias on the perceived odor, irritation and health symptoms from chemical exposure. Int. Arch. Occup. Environ. Health 69:407-417 (1997).
29. Berglund, B. and H. Shams Esfandabad: Humans as discerners of odor and irritation. In Fechner Day '92, G. Borg and G. Neely (ed.). Stockholm: International Society for Psychophysics, 1992. pp. 21-26.
30. Doty, R.L., W.E. Brugger, P.C. Jurs, M.A. Orndorff, P.J. Snyder, and L.D. Lowry: Intranasal trigeminal stimulation from odorous volatiles: Psychometric responses from anosmic and normal humans. Physiol. Behav. 20:175-185 (1978).
31. Kobal, G.: A new method for determination of the olfactory and the trigeminal nerve's dysfunction: Olfactory (OEP) and chemical somatosensory (CSEP) evoked potentials. In Event-Related Potentials in Children, A. Rothenberger (ed.). Amsterdam: Elsevier Biomedical Press, 1982. pp. 455-461.
32. Dalton, P., C.J. Wysocki, M.J. Brody, and H.J. Lawley: Perceived odor, irritation and health symptoms following short-term exposure to acetone. Am. J. Ind. Med. 31:558-569 (1997).
33. Bell, I.R., G.E. Schwartz, J.M. Peterson, and D. Amend: Self-reported illness from chemical odors in young adults without clinical syndromes or occupational exposures. Arch. Environ. Health 48:6-13 (1993).
34. Bell, I.R., G.E. Schwartz, J.M. Peterson, D. Amend, and W.A. Stini: Possible time-dependent sensitization to xenobiotics: Self-reported illness from chemical odors, foods, and opiate drugs in an older adult population. Arch. Environ. Health 48:315-327 (1993).
35. Green, B.G., P. Dalton, B. Cowart, G. Shaffer, K.R. Rankin, and J. Higgins: Evaluating the "Labeled Magnitude Scale" for measuring sensations of taste and smell. Chem. Senses 21:323-334 (1996).
36. Cowart, B.J., I.M. Young, R.S. Feldman, and L.D. Lowry: Clinical disorders of smell and taste. In Handbook of Perception and Cognition, vol. 8, G.K. Beauchamp and L.M. Bartoshuk (ed.). New York: Academic Press, 1997.
37. Dalton, P.: Odor perception and beliefs about risk. Chem. Senses 21: 447-458 (1996).
38. Colligan, M.J., and L. Murphy: A review of mass psychogenic illness in work settings. In Mass Psychogenic Illness: A Social Psychological Analysis, M. Colligan, J. Pennebaker, and L. Murphy (ed.). Hillsdale, N.J.: Lawrence Erlbaum, 1982.
39. Boss, L.P.: Epidemic hysteria: A review of the published literature. Epidemiol. Rev. 19:233-243 (1997).
40. Fernandez, E., and T.W. Milburn: Sensory and affective predictors of overall pain and emotions associated with affective pain. Clin. J. Pain 10:3-9 (1994).
41. Fernandez, E., and D.C. Turk: Sensory and affective components of pain: Separation and synthesis. Psychol. Bull. 112:205-217 (1992).
42. Devos, M., F. Patte, J. Rouault, P. Laffort, and L.J. Van Gemert: Standardized Human Olfactory Thresholds. New York: Oxford University Press, 1990. p. 116.
43. Smyth, H.F., C.P. Carpenter, and C.S. Weil: Range finding toxicity data: List IV. Arch. Ind. Hyg. Occup. Med. 4:119-122 (195).
44. Bernard, L.G., and R.M. David: A thirteen-week inhalation schedule-controlled operant behavior study in the rat. Rochester, N.Y.: Eastman Kodak Co., 1996.
45. Moore, P.A.: A model of the role of adaptation and disadaptation in olfactory receptor neurons: Implications for the coding of temporal and intensity patterns in odor signals. Chem. Senses 19:711-786 (1994).
46. Dalton, P.: Cognitive determinants of acute adverse health symptoms from chemical exposure. Health Psychol. (In press).
47. Green, B.G., and J. Bluth: Measuring the chemosensory irritability of human skin. J. Toxicol. Clin. Toxicol. 14:23-48 (1995).