Enzymatic activation of a new antitumour drug, 5-diethylaminoethylamino-8-hydroxyimidazoacridinone, C-1311, observed after its intercalation into DNA

Biochemical Pharmacology

Volumn 61, Issue 6, 2001, Pages 685-694

  Mazerska, Zofia ^a   Dziegielewski, Jaroslaw ^a   Konopa, Jerzy ^a  

^a GDANSK UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

Antitumour compounds; DNA intercalation; Enzymatic activation; Imidazoacridinone derivatives; Metabolic activation; Mode of antitumour action

Indexed keywords

DNA; HORSERADISH PEROXIDASE; HYDROGEN PEROXIDE; IMIDACRINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL FREE SYSTEM; COVALENT BOND; DRUG ACTIVATION; DRUG DNA INTERACTION; DRUG OXIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERCALATION COMPLEX; MASS SPECTROMETRY; METABOLIC ACTIVATION; PRIORITY JOURNAL; ULTRAVIOLET SPECTROSCOPY;

AMINOACRIDINES; ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA, VIRAL; HORSERADISH PEROXIDASE; HYDROGEN PEROXIDE; OXIDATION-REDUCTION; PRODRUGS; SIMIAN VIRUS 40; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0035868981     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00527-5     Document Type: Article

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