Toluene inhibits muscarinic receptor-mediated cytosolic Ca2+ responses in neural precursor cells

NeuroToxicology

Volumn 23, Issue 1, 2002, Pages 61-68

  Ma, Wu ^a   Shaffer, Kara M ^a   Pancrazio, Joseph J ^a   O'Shaughnessy, Thomas J ^a   Stenger, David A ^a   Zhang, Lei ^b   Barker, Jeffery L ^b   Maric, Dragan ^b  

^a NAVAL RESEARCH LABORATORY   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

5 Bromo 2 deoxyuridine; Ca2+ imaging; Muscarinic acetylcholine receptor; Neural stem cell; Toluene

Indexed keywords

ACETYLCHOLINE DERIVATIVE; ATROPINE; BASIC FIBROBLAST GROWTH FACTOR; BETA TUBULIN; BIOCHEMICAL MARKER; BROXURIDINE; CALCIUM ION; CARBACHOL; MUSCARINIC RECEPTOR BLOCKING AGENT; TOLUENE; CALCIUM; MUSCARINIC RECEPTOR;

ANIMAL CELL; ARTICLE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL ISOLATION; CELL MATURATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; GAS CHROMATOGRAPHY; IC 50; IMAGING; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MICROSCOPY; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; STEM CELL; ANIMAL; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; CYTOSOL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; METABOLISM; PHYSIOLOGY; PREGNANCY; SPRAGUE DAWLEY RAT; TELENCEPHALON;

ANIMALS; CALCIUM; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO; FEMALE; MUSCARINIC ANTAGONISTS; NEURONS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, MUSCARINIC; TELENCEPHALON; TOLUENE;

EID: 0036562505     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-813X(01)00084-5     Document Type: Article

References (24)

1. Altman J, Bayer SA. Atlas of prenatal rat brain development. CRC Press, Boca Raton, 1995.
2. Arnold GL, Kirby RS, Langendoerfer S, Wilkins-Haug L. Toluene embryopathy: clinical delineation and developmental follow-up. Pediatrics 1994;93:216-20.
3. Bennett AM, Williams GM. Calcium as a permissive factor but not an initiation factor in DNA synthesis induction in cultured rat hepatocytes by the peroxisome proliferator ciprofibrate. Biochem Pharmacol 1993;46:2219-27.
4. Borm PJA, Bast A, Zuiderveld OP. In vitro effect of toluene diisocyanate on β-adrenergic and muscarinic receptor function in lung-tissue of the rat. Brit J Ind Med 1989;46:56-9.
5. Carafoli E, Santella L, Branca D, Brini M. Generation, control, and processing of cellular calcium signals. Crit Rev Biochem Mol Biol 2001;36:107-260.
6. Catlin MC, Guizzetti M, Costa LG. Effect of ethanol on muscarinic receptor-induced calcium responses in astroglia. J Neurosci Res 2000;60:345-55.
7. Cruz SL, Mirshahi T, Thomas B, Balster RL, Woodward JJ. Effects of the abused solvent toluene on recombinant N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther 1998;286:334-40.
8. Gospe SM, Zhou SS. Toluene aduse embryopathy: longitudinal neurodevelopmental effects of prenatal exposure to toluene in rats. Reprod Toxicol 1998;12:119-26.
9. Gospe SM, Zhou SS. Prenatal exposure to toluene results in abnormal neurogenesis and migration in rat somatosensory cortex. Pediatr Res 2000;47:362-8.
10. Gospe SM, Saeed DB, Zhou SS, Zeman FJ. The effects of highdose toluene on embryonic development in the rat. Pediatr Res 1994;36:811-5.
11. Gospe SM, Saeed DB, Zhou SS, Zeman FJ. Development of a rat model of toluene-abuse embrypathy. Pediatr Res 1996;40: 82-7.
12. Hersh JH. Toluene embryopathy: two new cases. J Med Genet 1988;26:333.
13. Ikeuchi Y, Hirai H, Okada Y, Mio T, Matsuada T. Excitatory and inhibitory effects of toluene on neural activity in guinea pig hippocampal slices. Neurosci Lett 1993;158:63.
14. Lee MK, Tuttle JB, Rebhun LI, Cleveland DW, Frankfurter A. The expression and posttranslational modification of a neuron-specific β-tubulin isotope during chick embryogenesis. Cell Motil Cytoskeleton 1990;17:118-32.
15. - channels in vitro. J Neurobiol 1998;35:277-86.
16. Ma W, Maric D, Li B-S, Andreadis JD, Grant GM, Liu Q-Y, Schaffer KM, Chang Y-H, Zhang L, Pancrazio J, Pant HC, Stenger DA, Barker JL. Acetylcholine stimulates cortical precursor cell proliferation via muscarinic receptor activation and MAP kinase phosphorylation. Eur J Neurosci 2000;12:1227-40.
17. Ma W, Li B-S, Pant HC, Maric D, Lin HJ, Zhang L, Barker JL. Ethanol-induced cell loss in cultured neural precursor cells involves muscarinic receptor-mediated PI-3k-Akt signaling. The 4th Brain Research Interactive Symposium: Stem Cell in Mammalian Brain. Developmental Brain Research 2001.
18. - channels in cultured proliferating rat neuroepithelial cells. Neuroscience 2001;104:913-922.
19. Maric D, Maric I, Barker JL. Dual video microscopic imaging of membrane potential and cytosolic calcium of immuno-identified embryonic rat cortical cells. Methods 2000;21: 335-47.
20. Menezes JR, Luskin MB. Expression of neuron-specific tubulin defines a novel population in the proliferative layers of the developing telencephalon. J Neurosci 1994;14: 5399-416.
21. Pearson MA, Hoyme EH, Seaver LH. Toluene embryopathy: delineation of the phenotype and comparison with fetal alcohol syndrome. Pediatrics 1994;93:211.
22. Schaumburg HH. Toluene. In: Spencer P, Schaumburg HH, editors. Experimental and clinical neurotoxicology. New York: Oxford University Press, 2000. p. 1183-9.
23. Tsuga H, Honma T. Effects of short-term toluene exposure on ligand binding to muscarinic acetylcholine receptors in the rat frontal cortex and hippocampus. Neurotoxicol Teratol 2000; 22:603-6.
24. Tsuga H, Wang RS, Honma T. Effects of toluene on regulation of adenylyl cyclase by stimulation of G-protein coupled receptors expressed in CHO cells. Jpn J Pharmacol 1999;81:305-8.