-
2
-
-
0019222729
-
Flow dependence of first-order uptake of substances by heterogeneous perfused organs
-
BASS L. Flow dependence of first-order uptake of substances by heterogeneous perfused organs. J. theor. Biol. 86:1980;365-376.
-
(1980)
J. Theor. Biol.
, vol.86
, pp. 365-376
-
-
Bass, L.1
-
3
-
-
0023949942
-
Physiologically based models and strategic experiments in hepatic pharmacology
-
BASS L., KEIDING S. Physiologically based models and strategic experiments in hepatic pharmacology. Biochem. Pharmacol. 37:1988;1425-1431.
-
(1988)
Biochem. Pharmacol.
, vol.37
, pp. 1425-1431
-
-
Bass, L.1
Keiding, S.2
-
4
-
-
0017176322
-
Enzymatic elimination of substrates flowing through the intact liver
-
BASS L., KEIDING S., WINKLER K., TYGSTRUP N. Enzymatic elimination of substrates flowing through the intact liver. J. theor. Biol. 61:1976;393-409.
-
(1976)
J. Theor. Biol.
, vol.61
, pp. 393-409
-
-
Bass, L.1
Keiding, S.2
Winkler, K.3
Tygstrup, N.4
-
5
-
-
0023661747
-
On the relation between extended forms of the sinusoidal perfusion and of the convection-dispersion models of hepatic elimination
-
BASS L., ROBERTS M. S., ROBINSON P. J. On the relation between extended forms of the sinusoidal perfusion and of the convection-dispersion models of hepatic elimination. J. theor. Biol. 126:1987;457-482.
-
(1987)
J. Theor. Biol.
, vol.126
, pp. 457-482
-
-
Bass, L.1
Roberts, M.S.2
Robinson, P.J.3
-
6
-
-
0018190444
-
Hepatic elimination of flowing substrates: The distributed model
-
BASS L., ROBINSON P. J., BRACKEN A. J. Hepatic elimination of flowing substrates: the distributed model. J. theor. Biol. 72:1978;161-187.
-
(1978)
J. Theor. Biol.
, vol.72
, pp. 161-187
-
-
Bass, L.1
Robinson, P.J.2
Bracken, A.J.3
-
7
-
-
0018472848
-
Statistical mechanics of hepatic elimination
-
BRACKEN A. J., BASS L. Statistical mechanics of hepatic elimination. Math. Biosci. 44:1979;97-120.
-
(1979)
Math. Biosci.
, vol.44
, pp. 97-120
-
-
Bracken, A.J.1
Bass, L.2
-
8
-
-
0027374635
-
Relationship between lipophilicity and hepatic dispersion and distribution for a homologous series of barbiturates in the isolated perfused in situ rat liver
-
CHOU C. H., EVANS A. M., FORNASINI G., ROWLAND M. Relationship between lipophilicity and hepatic dispersion and distribution for a homologous series of barbiturates in the isolated perfused in situ rat liver. Drug Metab. Disp. 21:1993;933-938.
-
(1993)
Drug Metab. Disp.
, vol.21
, pp. 933-938
-
-
Chou, C.H.1
Evans, A.M.2
Fornasini, G.3
Rowland, M.4
-
9
-
-
0027156179
-
Influence of albumin on the distribution and elimination kinetics of diclofenac in the isolated perfused rat liver: Analysis by the impulse-response technique and the dispersion model
-
EVANS A. M., HUSSEIN Z., ROWLAND M. Influence of albumin on the distribution and elimination kinetics of diclofenac in the isolated perfused rat liver: analysis by the impulse-response technique and the dispersion model. J. Pharm. Sci. 82:1993;421-428.
-
(1993)
J. Pharm. Sci.
, vol.82
, pp. 421-428
-
-
Evans, A.M.1
Hussein, Z.2
Rowland, M.3
-
10
-
-
0001244133
-
A linear method for determining liver sinusoidal and extravascular volumes
-
GORESKY C. A. A linear method for determining liver sinusoidal and extravascular volumes. Am. J. Physiol. 204:1963;626-640.
-
(1963)
Am. J. Physiol.
, vol.204
, pp. 626-640
-
-
Goresky, C.A.1
-
11
-
-
0015620354
-
On the uptake of materials by the intact liver: The transport and net removal of galactose
-
GORESKY C. A., BACH G. G., NADEAU B. E. On the uptake of materials by the intact liver: the transport and net removal of galactose. J. Clin. Invest. 52:1973;991-1009.
-
(1973)
J. Clin. Invest.
, vol.52
, pp. 991-1009
-
-
Goresky, C.A.1
Bach, G.G.2
Nadeau, B.E.3
-
12
-
-
0020774956
-
Functional and anatomical heterogeneity in the liver acinus: Impact on transport
-
GUMUCIO J. J. Functional and anatomical heterogeneity in the liver acinus: impact on transport. Am. J. Physiol. 244:1983;G578-G582.
-
(1983)
Am. J. Physiol.
, vol.244
-
-
Gumucio, J.J.1
-
13
-
-
0019350665
-
Functional implications of liver cell heterogeneity
-
GUMUCIO J. J., MILLER D. L. Functional implications of liver cell heterogeneity. Gastroenterology. 80:1981;393-403.
-
(1981)
Gastroenterology
, vol.80
, pp. 393-403
-
-
Gumucio, J.J.1
Miller, D.L.2
-
14
-
-
0031827417
-
Hepatic structure-pharmacokinetic relationship: The hepatic disposition and metabolite kinetics of a homologous series of O-acyl derivatives of salicylic acid
-
HUNG D. Y., MELLICK G. D., ANISSIMOV Y. G., WEISS M., ROBERTS M. S. Hepatic structure-pharmacokinetic relationship: the hepatic disposition and metabolite kinetics of a homologous series of O-acyl derivatives of salicylic acid. Br. J. Pharmacol. 124:1998a;1475-1483.
-
(1998)
Br. J. Pharmacol.
, vol.124
, pp. 1475-1483
-
-
Hung, D.Y.1
Mellick, G.D.2
Anissimov, Y.G.3
Weiss, M.4
Roberts, M.S.5
-
15
-
-
0031875143
-
Hepatic disposition and metabolite kinetics of a homologous series of a homologous series of diflunisal esters
-
HUNG D. Y., MELLICK G. D., ANISSIMOV Y. G., WEISS M., ROBERTS M. S. Hepatic disposition and metabolite kinetics of a homologous series of a homologous series of diflunisal esters. J. Pharm. Sci. 87:1998b;943-951.
-
(1998)
J. Pharm. Sci.
, vol.87
, pp. 943-951
-
-
Hung, D.Y.1
Mellick, G.D.2
Anissimov, Y.G.3
Weiss, M.4
Roberts, M.S.5
-
16
-
-
0027936977
-
The distribution kinetics of salicylic acid in the isolated perfused rat liver assessed using moment analysis and the two-compartment axial dispersion model
-
HUSSEIN Z., MCLACHLAN A. J., ROWLAND M. The distribution kinetics of salicylic acid in the isolated perfused rat liver assessed using moment analysis and the two-compartment axial dispersion model. Pharm. Res. 11:1994;1337-1345.
-
(1994)
Pharm. Res.
, vol.11
, pp. 1337-1345
-
-
Hussein, Z.1
McLachlan, A.J.2
Rowland, M.3
-
17
-
-
8544229104
-
Prediction of in vivo hepatic metabolic clearance of YM796 from in vitro data by use of human liver microsomes and recombinant P-450 isozymes
-
IWATSUBO T., SUZUKI H., SHIMADA N., CHIBA K., ISHIZAKI T., GREEN C. E., TYSON C. A., YOKOI T., KAMATAKI T., SUGIYAMA Y. Prediction of in vivo hepatic metabolic clearance of YM796 from in vitro data by use of human liver microsomes and recombinant P-450 isozymes. J. Pharmacol. Exp. Ther. 282:1997;909-919.
-
(1997)
J. Pharmacol. Exp. Ther.
, vol.282
, pp. 909-919
-
-
Iwatsubo, T.1
Suzuki, H.2
Shimada, N.3
Chiba, K.4
Ishizaki, T.5
Green, C.E.6
Tyson, C.A.7
Yokoi, T.8
Kamataki, T.9
Sugiyama, Y.10
-
19
-
-
0027447136
-
Extending the multiple indicator dilution method to include slow intracellular diffusion
-
LUXON B. A., WEISIGER R. A. Extending the multiple indicator dilution method to include slow intracellular diffusion. Math. Biosci. 113:1993;211-230.
-
(1993)
Math. Biosci.
, vol.113
, pp. 211-230
-
-
Luxon, B.A.1
Weisiger, R.A.2
-
20
-
-
0026629456
-
Axial tissue diffusion can account for the disparity between current models of hepatic elimination for lipophillic drugs
-
RIVORY L. P., ROBERTS M. S., POND S. M. Axial tissue diffusion can account for the disparity between current models of hepatic elimination for lipophillic drugs. J. Pharmacokin Biopharm. 20:1992;19-61.
-
(1992)
J. Pharmacokin Biopharm.
, vol.20
, pp. 19-61
-
-
Rivory, L.P.1
Roberts, M.S.2
Pond, S.M.3
-
21
-
-
0344783927
-
Relative dispersions of intra-albumin transit times across perfused rat and elasmobranch livers and implications of intra- And inter species scaling of hepatic clearance using microsomal data
-
ROBERTS M. S., BALLINGER L. N., WEISS M. Relative dispersions of intra-albumin transit times across perfused rat and elasmobranch livers and implications of intra- and inter species scaling of hepatic clearance using microsomal data. J. Pharm. Pharmacol. 1999.
-
(1999)
J. Pharm. Pharmacol.
-
-
Roberts, M.S.1
Ballinger, L.N.2
Weiss, M.3
-
22
-
-
0023933009
-
Models of hepatic elimination: Comparison of stochastic models to describe residence time distributions and to predict the influence of drug distribution, enzyme heterogeneity and systemic recycling on hepatic elimination
-
ROBERTS M. S., DONALDSON J. D., ROWLAND M. Models of hepatic elimination: comparison of stochastic models to describe residence time distributions and to predict the influence of drug distribution, enzyme heterogeneity and systemic recycling on hepatic elimination. J. Pharmacokin. Biopharm. 16:1988;41-83.
-
(1988)
J. Pharmacokin. Biopharm.
, vol.16
, pp. 41-83
-
-
Roberts, M.S.1
Donaldson, J.D.2
Rowland, M.3
-
23
-
-
0025120462
-
Residence time distributions of solutes in the perfused rat liver using a dispersion model of hepatic elimination: 1. Effect of changes in perfusate flow and albumin concentration on sucrose and taurocholate
-
ROBERTS M. S., FRASER S., WAGNER A., MCLEOD L. Residence time distributions of solutes in the perfused rat liver using a dispersion model of hepatic elimination: 1. Effect of changes in perfusate flow and albumin concentration on sucrose and taurocholate. J. Pharmocokin. Biopharm. 18:1990a;209-234.
-
(1990)
J. Pharmocokin. Biopharm.
, vol.18
, pp. 209-234
-
-
Roberts, M.S.1
Fraser, S.2
Wagner, A.3
McLeod, L.4
-
24
-
-
0025081862
-
Residence time distributions of solutes in the perfused rat liver using a dispersion model of hepatic elimination: 2. Effect of pharmacological agents, retrograde perfusions, and enzyme inhibition on Evans blue, sucrose, water, and taurocholate
-
ROBERTS M. S., FRASER S., WAGNER A., MCLEOD L. Residence time distributions of solutes in the perfused rat liver using a dispersion model of hepatic elimination: 2. Effect of pharmacological agents, retrograde perfusions, and enzyme inhibition on Evans blue, sucrose, water, and taurocholate. J. Pharmocokin. Biopharm. 18:1990b;235-258.
-
(1990)
J. Pharmocokin. Biopharm.
, vol.18
, pp. 235-258
-
-
Roberts, M.S.1
Fraser, S.2
Wagner, A.3
McLeod, L.4
-
25
-
-
0021798973
-
Hepatic elimination - dispersion model
-
ROBERTS M. S., ROWLAND M. Hepatic elimination - dispersion model. J. Pharm. Sci. 74:1985;585-587.
-
(1985)
J. Pharm. Sci.
, vol.74
, pp. 585-587
-
-
Roberts, M.S.1
Rowland, M.2
-
26
-
-
0022549973
-
A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations
-
ROBERTS M. S., ROWLAND M. A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations. J. Pharmacokin. Biopharm. 14:1986a;227-260.
-
(1986)
J. Pharmacokin. Biopharm.
, vol.14
, pp. 227-260
-
-
Roberts, M.S.1
Rowland, M.2
-
27
-
-
0022552317
-
A dispersion model of hepatic elimination: 2. Steady-state considerations. Influence of blood flow, protein binding and hepatocellular enzymatic activity
-
ROBERTS M. S., ROWLAND M. A dispersion model of hepatic elimination: 2. Steady-state considerations. Influence of blood flow, protein binding and hepatocellular enzymatic activity. J. Pharmacokin. Biopharm. 14:1986b;261-288.
-
(1986)
J. Pharmacokin. Biopharm.
, vol.14
, pp. 261-288
-
-
Roberts, M.S.1
Rowland, M.2
-
28
-
-
0022922022
-
A dispersion model of hepatic elimination: 3. Application to metabolite formation and elimination kinetics
-
ROBERTS M. S., ROWLAND M. A dispersion model of hepatic elimination: 3. Application to metabolite formation and elimination kinetics. J. Pharmacokin. Biopharm. 14:1986c;289-307.
-
(1986)
J. Pharmacokin. Biopharm.
, vol.14
, pp. 289-307
-
-
Roberts, M.S.1
Rowland, M.2
-
29
-
-
0022609024
-
Correlation between in-vitro microsomal enzyme activity and whole organ hepatic elimination kinetics: Analysis with a dispersion model
-
ROBERTS M. S., ROWLAND M. Correlation between in-vitro microsomal enzyme activity and whole organ hepatic elimination kinetics: analysis with a dispersion model. J. Pharm. Pharmacol. 38:1986d;177-181.
-
(1986)
J. Pharm. Pharmacol.
, vol.38
, pp. 177-181
-
-
Roberts, M.S.1
Rowland, M.2
-
30
-
-
0031960023
-
Assessment of hepatic blood flow using continuous infusion of high clearance drugs
-
SCHOEMAKER R. C., BURGGRAAF J., COHEN A. F. Assessment of hepatic blood flow using continuous infusion of high clearance drugs. Br. J. Clin. Pharmacol. 45:1998;463-469.
-
(1998)
Br. J. Clin. Pharmacol.
, vol.45
, pp. 463-469
-
-
Schoemaker, R.C.1
Burggraaf, J.2
Cohen, A.F.3
-
31
-
-
0032171528
-
Kinetic analysis of vascular marker distribution in perfused rat livers after regeneration following partial hepatectomy
-
WEISS M., BALLINGER L. N., ROBERTS M. S. Kinetic analysis of vascular marker distribution in perfused rat livers after regeneration following partial hepatectomy. J. Hepatol. 29:1998;476-481.
-
(1998)
J. Hepatol.
, vol.29
, pp. 476-481
-
-
Weiss, M.1
Ballinger, L.N.2
Roberts, M.S.3
-
32
-
-
0029759461
-
Tissue distribution kinetics as a determinant of transit time dispersion of drugs in organs: Application of a stochastic model for the rat hindlimb
-
WEISS M., ROBERTS M. S. Tissue distribution kinetics as a determinant of transit time dispersion of drugs in organs: application of a stochastic model for the rat hindlimb. J. Pharmacokin. Biopharm. 24:1996;173-196.
-
(1996)
J. Pharmacokin. Biopharm.
, vol.24
, pp. 173-196
-
-
Weiss, M.1
Roberts, M.S.2
-
33
-
-
0024328692
-
Two-compartment dispersion model for analysis of organ perfusion system of drugs by fast inverse Laplace transform (FILT)
-
YANO Y., YAMAOKA K., AOYAMA Y., TANAKA H. Two-compartment dispersion model for analysis of organ perfusion system of drugs by fast inverse Laplace transform (FILT). J. Pharmacokin. Biopharm. 17:1989;179-202.
-
(1989)
J. Pharmacokin. Biopharm.
, vol.17
, pp. 179-202
-
-
Yano, Y.1
Yamaoka, K.2
Aoyama, Y.3
Tanaka, H.4
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