Hyperoxia prolongs tumor necrosis factor-α-mediated activation of Nf-κB: Role of IκB kinase

Shock

Volumn 17, Issue 4, 2002, Pages 274-279

  Wong, Hector R ^a   Odoms, Kelli K ^a   Denenberg, Alvin G ^a   Allen, Geoffrey L ^a   Shanley, Thomas P ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Inflammation; Lung injury; Oxidants; Signal transduction; Transcription factor

Indexed keywords

CHUK PROTEIN, HUMAN; DNA BINDING PROTEIN; I KAPPA B; I KAPPA B BETA; I KAPPA B KINASE; IKBKB PROTEIN, HUMAN; IKBKE PROTEIN, HUMAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; PROTEIN SERINE THREONINE KINASE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL LINE; ENZYME ACTIVATION; GENE EXPRESSION; GENETICS; HUMAN; HYPEROXIA; INJURY; LUNG; METABOLISM; PROMOTER REGION; SIGNAL TRANSDUCTION;

CELL LINE; DNA-BINDING PROTEINS; ENZYME ACTIVATION; GENE EXPRESSION; HUMANS; HYPEROXIA; I-KAPPA B KINASE; I-KAPPA B PROTEINS; INTERCELLULAR ADHESION MOLECULE-1; LUNG; NF-KAPPA B; PROMOTER REGIONS (GENETICS); PROTEIN-SERINE-THREONINE KINASES; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036546812     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-200204000-00006     Document Type: Article

References (27)

1. Ghosh S, May MJ, Koop EB: NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16:225-260, 1998.
2. Karin M, Ben-Neriah Y: Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu Rev Immunol 18:621-663, 2000.
3. Schwartz MD, Moore EE, Moore FA, Shenkar R, Moine P, Haenel JB, Abraham E: Nuclear factor-κB is activated in alveolar macrophages from patients with acute respiratory distress syndrome. Crit Care Med 24:1285-1292, 1996.
4. Moine P, McIntyre R, Schwartz M, Kaneko D, Shenkar R, Tulzo YL, Moore E, Abraham E: NF-κB regulatory mechanisms in alveolar macrophages from patients with acute respiratory distress syndrome. Shock 13:85-91, 2000.
5. Bohrer H, Qiu F, Zimmerman T, Zhang Y, Jllmer T, Mannel D, Bottiger BW, Stern D, Waldherr R, Saeger H-D, Ziegler R, Bierhaus A, Martin E, Nawtroth PP: Role of NF-κB in the mortality of sepsis. J Clin Invest 100:972-985, 1997.
6. Blackwell TS, Blackwell TR, Holden E, Christman B, and Christman J: In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutro-phil lung inflammation. J Immunol 157:1630-1637, 1996.
7. Lentsch A, Shanley TP, Sarma V, Ward P: In vivo suppression of NF-κB and preservation of I kappa B alpha by interleukin-10 and interleukin-13. J Clin Invest 100:2443-2448, 1997.
8. Ross S, Kron I, Gangemi J, Shockey K, Stoler M, Kern J, Tribble C, Laubach V: Attenuation of lung reperfusion injury after transplantation using an inhibitor of nuclear factor-kappaB. Am J Physiol 279:L528-L536, 2000.
9. Yoshidome H, Kato A, Edwards M, Lentsch A: Interleukin-10 inhibits pulmonary NF-κB activation and lung injury induced by hepatic ischemia-reperfusion. Am J Physiol 277:L919-L923, 1999
10. Cooke K, Hill G, Gerbitz A, Kobzik L, Martin T, Crawford J, Brewer J, Ferrara J: Tumor necrosis factor-alpha neutralization reduces lung injury after experimental allogeneic bone marrow transplantation. Transplantation 70:272-279, 2000.
11. Davidson B, Knight P, Helinski J, Nader N, Shanley T, Johnson K: The role of tumor necrosis factor-alpha in the pathogenesis of aspiration pneumonitis in rats. Anesthesiology 91:486-499, 1999.
12. Dixon A, Mandae J, Madtes D, Martin P, Clark J: Chemokine expression in ThI cell-induced lung injury: prominence of IFN-γ-inducible chemokines. Am J Physiol 279:L592-L599, 2000.
13. Rabinovici R, Feuerstein G, Abdullah F, Whiteford M, Borboroglu P, Sheikh E, Phillip D, Ovadia P, Bobroski L, Bagasra O, Neville L: Locally produced tumor necrosis factor-alpha mediates interleukin-2-inducted lung injury. Circ Res 78: 329-336, 1996.
14. Wispé JR, Roberts RJ: Molecular basis of pulmonary oxygen toxicity. Clin Perinatol 14:651-666, 1987.
15. Jenkinson SG: Oxygen toxicity. New Horiz 1:504-511, 1993.
16. Allen G, Menendez I, Ryan M, Mazor R, Wispé J, Fiedler M. Wong H: Hyperoxia synergistically increases TNF-α-induced interleukin-8 gene expression in A549 cells. Am J Physiol 278:L253-L260, 2000.
17. Mukaida N, Okamoto S, Ishikawa Y, Matsushima K: Molecular mechanisms of interleukin-8 gene expression. J Leukoc Biol 56:554-558, 1994.
18. Wong HR, Ryan M, Wispé JR: Stress response decreases NF-κB nuclear translocation and increases I-κBα and expression in A549 cells. J Clin Invest 99: 2423-2428, 1997.
19. Chini BA, Fiedler MA, Milligan L, Hopkins T, Stark JM: Essential roles of NF-αB and C/EBP in the regulation of intercellular adhesion molecule-1 after respiratory syncytial virus infection of human respiratory epithelium. J Virol 72:1623-1626, 1998.
20. Johnson DR, Douglas I, Jahnke A, Ghosh S, Pober JS: A sustained reduction in IκB-β may contribute to persistent NF-κB activation in human endothelial cells. J Biol Chem 271:16317-16322, 1996.
21. Suyang H, Philips R, Douglas I, Ghosh S: Role of unphosphorylated, newly synthesized IκBβ in persistent activation of NF-κB. Mol Cell Biol 16:5444-5449, 1996.
22. Schreck R, Meier B, Mannel DN, Droge W, Baeuerle PA: Dithiocarbamates as potent inhibitors of nuclear factor KB activation in intact cells. J Exp Med 175:1181-1194, 1992.
23. Li Y, Mantell L, Kazzaz J, Fein A, Horowitz S: Nuclear factor-kappaB is activated by hyperoxia but does not protect from cell death. J Biol Chem 272:20646-20649, 1997.
24. Shea L, Beehler C, Schwartz M, Shenkar R, Tuder R, Abraham E: Hyperoxia activates NF-κB and increases TNF-α and IFN-γ gene expression in mouse pulmonary lymphocytes. J Immunol 157:3902-3908, 1996.
25. Cheng Q, Cant CA, Moll T, Hofer-Warbinek R, Wagner E, Birnstiel ML, Bach FH, deMartin R: NF-κB subunit-specific regulation of the IκBα promoter. J Biol Chem 269:13551-13557, 1994.
26. Ito CY, Kazantsev AG, Baldwin AS: Three NF-κB sites in the IκB-α promoter are required for induction of gene expression by TNFα. Nucleic Acids Res 22:3787-3792, 1994.
27. Martin RD, Vanhove B, Cheng Q, Hofer E, Csizmadia V, Winkler H, Bach FH: Cytokine-inducible expression in endothelial cells of an IκBα-like gene is regulated by NFκB. EMBO J 12:2773-2779, 1993.