Induction of cytochrome P450 1A and 2B by α- and β-ionone in Sprague Dawley rats

Archives of Pharmacal Research

Volumn 25, Issue 2, 2002, Pages 197-201

  Hye, Gwang Jeong ^a   Chun, Young Jin ^b   Yun, Chul Ho ^c   Moon, Chang Kiu ^d   Lee, Hye Sook ^e   Han, Sang Seop ^f   Lee, Eung Seok ^g   Jeong, Tae Cheon ^g  

^a Chosun University   (South Korea)

^b Chung Ang University   (South Korea)

^c PaiChai University   (South Korea)

^d Seoul National University   (South Korea)

^e Wonkwang University   (South Korea)

^f Korea Research Institute of Chemical Technology   (South Korea)

^g Yeungnam University   (South Korea)

Author keywords

Cytochrome P450 2B; Induction; Ionones

Indexed keywords

ALPHA IONONE; ALPHA-IONONE; BETA IONONE; BETA-IONONE; CYTOCHROME P450 1A1; CYTOCHROME P450 2B1; MESSENGER RNA; NORISOPRENOID; TERPENE;

ANIMAL; ARTICLE; BIOSYNTHESIS; DRUG EFFECT; ENZYME INDUCTION; GENETICS; MALE; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2B1; ENZYME INDUCTION; MALE; NORISOPRENOIDS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TERPENES;

EID: 0036545548     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/bf02976563     Document Type: Article

References (16)

1. 4-induced liver injury by a single dose of retinol. Toxicol. Appl. Pharmacol., 141, 507-519 (1996).
2. Boelsterli, U. A., Lanzotti, A., Göldlin, C., and Oertle, M., Identification of cytochrome P-450IIB1 as a cocaine-bioactivating isoform in rat hepatic microsomes and in cultured rat hepatocytes. Drug Metabol. Dispos., 20, 96-101 (1992).
3. Bradford, M. M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the protein-dye binding. Anal. Biochem., 72, 248-254 (1976).
4. Jeong, T. C., Gu, H. K., Chun, Y. J., Yun, C. -H., Han, S. S., and Roh, J. K., Effects of β-ionone on the expression of cytochrome P450s and NADPH-cytochrome P450 reductase in Sprague Dawley rats. Chem. Biol. Interact., 114, 97-107 (1998).
5. Jeong, T. C., Gu, H. K., Park, J. -I., Yun, H. -I., Kim, H. C., Ha, C. S., and Roh, J. K., Pretreatment of male BALB/c mice with β-ionone potentiates thioacetamide-induced hepatotoxicity. Toxicol. Lett., 105, 39-46 (1999).
6. Jeong, T. C., Jordan, S. D., Matulka, R. A., Stanulis, E. D., Kaminski, E. J., and Holsapple, M. P., Role of metabolism by esterase and cytochrome P-450 in cocaine-induced suppression of the antibody response. J. Pharmacol. Exp. Ther., 272, 407-416 (1995a).
7. Jeong, T. C., Jordan, S. D., Matulka, R. A., Stanulis, E. D., Park, S. S, and Holsapple, M. P., Immunosuppression by acute exposure to cocaine is dependent on metabolism by cytochrome P-450. J. Pharmacol. Exp. Ther., 276, 1257-1265 (1996).
8. Jeong, T. C., Kim, H. J., Yun, C. -H., Lee, S. S., Yang, K. H., Han, S. S., and Roh, J. K., Induction of liver cytochrome P450 2B1 by β-ionone in Sprague Dawley rats. Biochem. Biophys. Res. Commun., 216, 198-202 (1995b).
9. Kaminsky, L. S., Fasco, M. J. and Guengerich, F. P., Production and application of antibodies to rat liver cytochrome P-450. Meth. Enzymol., 74, 262-272 (1981).
10. 2-receptor antagonists on cytochrome P450 in male ICR mice. Human Exp. Toxicol., 14, 623-629 (1995).
11. Naves, Y. R., Some developments in the chemistry of ionones and their derivatives- a subject review. J. Soc. Cosm. Chem. 22, 439-456 (1971).
12. Parke, D. V. and Rahman, H., The effects of some terpenoids and other dietary nutrients on hepatic drug-metabolizing enzymes. Biochem. J., 113, 12 (1969).
13. Roth, L., Harbison, R. D., James, R. C., Tobin, T., and Roberts, S. M., Cocaine hepatotoxicity: influence of hepatic enzyme inducing and inhibiting agents on the site of necrosis. Hepatology, 15, 934-940 (1992).
14. Sauer, J. -M. and Sipes, I. G., Modulation of chemical-induced lung and liver toxicity by all-trans-retinol in the male Sprague-Dawley rats. Toxicology, 105, 237-249 (1995).
15. Thompson, M. L., Shuster, L., Casey, E., and Kanel, G. C., Sex and strain differences in response to cocaine. Biochem. Pharmacol., 33, 1299-1307 (1984).
16. Wrighton, S. A. and Stevens, J. C., The human hepatic cytochrome P450 involved in drug metabolism. Crit. Rev. Toxicol., 22, 1-21 (1992).