Lysophosphatidic acid stimulates proliferation of cultured smooth muscle cells from human BPH tissue: Sildenafil and papaverin generate inhibition

Prostate

Volumn 51, Issue 1, 2002, Pages 50-58

  Adolfsson, Per I ^a   Ahlstrand, Christer ^a   Varenhorst, Eberhard ^a   Svensson, Samuel P S ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

Author keywords

35S methionine; 3H thymidine; AC; BPH; cAMP; cGMP; Hyperplastic; PDE; Proliferation; SMC

Indexed keywords

ADENYLATE CYCLASE ACTIVATOR; CYCLIC AMP; CYCLIC GMP; FORSKOLIN; LYSOPHOSPHATIDIC ACID; METHIONINE; PAPAVERINE; PHOSPHODIESTERASE INHIBITOR; SILDENAFIL; THYMIDINE; TRITIUM; ZAPRINAST;

ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DNA REPLICATION; DNA SYNTHESIS; DOSE RESPONSE; HUMAN; HUMAN TISSUE; INHIBITION KINETICS; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; PROTEIN SYNTHESIS; SMOOTH MUSCLE FIBER; TRANSURETHRAL RESECTION;

CELL DIVISION; CELLS, CULTURED; CYCLIC AMP; CYCLIC GMP; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; FORSKOLIN; GROWTH INHIBITORS; HUMANS; LYSOPHOSPHOLIPIDS; MALE; MUSCLE, SMOOTH; PAPAVERINE; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PROSTATIC HYPERPLASIA; PROTEIN BIOSYNTHESIS; PROTEINS; PURINONES; STIMULATION, CHEMICAL;

EID: 0036534756     PISSN: 02704137     EISSN: None     Source Type: Journal    
DOI: 10.1002/pros.10077     Document Type: Article

References (44)

1. Human benign prostatic hyperplasia: Etiological considerations
2. Urologists on a tightrope: Coping with a changing economy
3. Lysophosphatide induced cell proliferation: Identification and dissection of signaling pathways mediated by G-proteins
4. Bioactive lysophospholipids and their G-protein-coupled receptors
5. Synergistic stimulation of airway smooth muscle cell mitogenesis
6. Lysophosphatidic acid as a phospholipid mediator: Pathway of synthesis
7. Lysophosphatidic acid: G-protein signaling and cellular responses
8. Lysophosphatidic acid, a multifunctional phospholipid messenger
9. Mitogenic signaling in androgen sensitive and insensitive prostate cancer cell lines
10. Molecular cloning and characterization of a lysophasphatidic acid receptor, Edg-7, expressed in prostate
11. Characterization of a novel subtype of human G-protein coupled receptor for lysophosphatidic acid
12. Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization
13. Different proliferative responses of Gi/0-protein coupled receptors in human myometrial smooth muscle cells: A possible role of calcium
14. Molecular cloning and characterization of a novel human G-protein coupled receptor, EDG7, for lysophosphatidic acid
15. Endocrine treatment in prostate cancer
16. The use of α-adrenoceptor antagonists in the pharmacological management of benign prostatic hypertrophy: An overview
17. Epidermal growth factor and prostatic carcinoma: An immunohistochemical study
18. Quantitative analysis of epidermal growth factor in human benign prostatic hyperplasia and prostatic carcinoma and its prognostic significance
19. Androgen ablation and blockade of the treatment of benign prostate hyperplasia
20. α1-Adrenergic stimulation and β2-adrenergic inhibition of DNA synthesis in vascular smooth muscle cells
21. Adrenergic receptor mediated regulation of cultured rabbit airway smooth muscle cell proliferation
22. Changes in β2-adrenergic receptor expression, adenylyl cyclase- and phosphodiesterase activity in human uterine leiomyomas
23. Salbutamol inhibits the proliferation of human airway smooth muscle grown in culture: Relationship to elevated cAMP levels
24. cGMP eleveting agents suppress proliferation of vascular smooth muscle cells by inhibiting the activation of epidermal growth factor signaling pathway
25. Antiproliferative effect in human prostate smooth muscle cells by nitric oxide donor
26. Molecular cloning and expression of human cGMP-binding cGMP-specific phosphodiesterase (PDE5)
27. Molecular cloning and characterization of distinct human phosphodiesterase gene family
28. The effect of papaverin on morphologic differentiation, proliferation and invasive potential on human prostatic cancer LNCaP cells
29. Alpha-1 receptor mediated smooth muscle regulation in benign prostatic hyperplasia
30. Etiology and disease process of benign prostate hyerplasia
31. A monoclonal antibody against alpha-smooth muscle actin: A new probe for smooth muscle differentiation
32. Lysophosphatidic acid and EGF stimulate mitogenesis in human airway smooth muscle cells
33. 2+ of human vascular smooth muscle cells in culture
34. Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex
35. Inhibition of cyclic GMP-binding cyclic GMP specific phosphodiesterase (type 5) by sildenafil and related compounds
36. Inhibition of platelet activity by S-nitrosoglutathione during coronary angioplasty
37. A possible role of decreased relaxation mediated by beta-adrenoceptors in bladder outlet obstruction by benign prostatic hyperplasia
38. Quantification and distribution of alpha 1-adrenoceptor subtype mRNA in the human prostate: Comparison of benign hypertrophied tissue and non-hypertrophied tissue
39. The etiology of benign prostatic hypertrophy
40. 2+ signaling pathways
41. Lysophosphatidic acid as a potential biomarker for ovarian and other gynecologic cancers
42. Modulation of the differentiation status of cultured prostatic smooth muscle cells by an alphal-adrenergic receptor antagonist
43. α1-Adrenoceptor antagonists terazosin and doxazosin induce prostate apoptosis without affecting cell proliferation in patients with benign prostatic hyperplasia
44. i and phosphoinositide 3-kinase