Rad6 overexpression induces multinucleation, centrosome amplification, abnormal mitosis, aneuploidy, and transformation

Cancer Research

Volumn 62, Issue 7, 2002, Pages 2115-2124

  Shekhar, Malathy P V ^a   Lyakhovich, Alex ^a   Visscher, Daniel W ^a   Heng, Henry ^a   Kondrat, Noelle ^a  

^a KARMANOS CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GAMMA TUBULIN; HISTONE H2B; MESSENGER RNA; RAD6 PROTEIN; TRANSCRIPTION FACTOR; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ANEUPLOIDY; ANIMAL CELL; ARTICLE; BREAST METASTASIS; BREAST TUMOR; CELL NUCLEUS; CENTROSOME; CONTROLLED STUDY; CYTOPLASM; DNA REPAIR; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MALIGNANT TRANSFORMATION; MITOSIS SPINDLE; MOUSE; MULTINUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

ANEUPLOIDY; ANIMALS; BREAST NEOPLASMS; CELL ADHESION; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; CENTROSOME; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; HUMANS; IMMUNOHISTOCHEMISTRY; LIGASES; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MITOSIS; RNA, MESSENGER; TUMOR CELLS, CULTURED; UBIQUITIN; UBIQUITIN-CONJUGATING ENZYMES;

EID: 0036532135     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. DNA synthesis errors, mutators and cancer
2. The Rad6 DNA repair pathway in Saccharomyces cerevisiae: What does it do, and how does it do it?
3. Rad6 gene of Saccharomyces cerevisiae encodes a protein containing a tract of 13 consecutive aspartates
4. The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme
5. Mutagenesis in Saccharomyces cerevisiae
6. Life cycle and inheritance
7. The yeast cell cycle gene CDC34 encodes a ubiquitin conjugating enzyme
8. Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6
9. Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31
10. Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification
11. Characterization of metastatic heterogeneity among subpopulations of a single mouse mammary tumor
12. Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor
13. Isolation and characterization of a spontaneously immortalized human breast epithelial line, MCF10
14. Direct action of estrogen on sequence of progression of human preneoplastic breast disease
15. MCFIODCIS.com xenograft model of human comedo ductal carcinoma in situ
16. Distribution and cloning of eukaryotic mRNAs by means of differential display: Refinements and optimization
17. The growth arrest-specific gene, gas1, is involved in growth suppression
18. Environmental estrogen stimulation of growth and estrogen receptor function in preneoplastic and cancerous human breast cell lines
19. Modes of DAP1 banding and simultaneous in situ hybridization
20. Spectral karyotyping of mouse cell line WMP2
21. Genetic instabilities in human cancers
22. Genetic instability of cancer cells is proportional to their degree of aneuploidy
23. Genomic integrity and cancer
24. Genetic instability in colorectal cancers
25. Defects in a cell cycle check point may be responsible for the genomic instability of cancer cells
26. The centrosome - A tiny organelle with big potential
27. CP60: A microtubule associated protein that is localized to the centrosome in a cell cycle-specific manner
28. Phosphoproteins are components of mitotic microtubule organizing centers
29. Cell cycle-regulated localization of tyrosine and threonine phosphoepitopes at the kinetochores of mitotic chromosomes
30. Taxol-induced microtubule asters in mitotic extracts of Xenopus eggs: Requirement for phosphorylated factors and cytoplasmic dynein
31. Regulation of the microtubule nucleating activity of centrosomes in Xenopus egg extracts: Role of cyclin A-associated protein kinase
32. A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators
33. Dynamic changes in nuclear architecture during mitosis: On the role of protein phosphorylation in spindle assembly and chromosome segregation
34. Antibody microinjection reveals an essential role for human polo-like kinase I (Plk I) in the functional maturation of mitotic centrosomes