Hyperhomocysteinemia increases the risk of venous thrombosis independent of the C677T mutation of the methylenetetrahydrofolate reductase gene in selected Brazilian patients

Blood Coagulation and Fibrinolysis

Volumn 13, Issue 3, 2002, Pages 271-275

  Morelli, Vânia M ^a   Lourenco D M ^a   D'Almeida, V ^a   Franco, R F ^a   Miranda, F ^a   Zago, M A ^a   Noguti, M A E ^a   Cruz, E ^a   Kerbauy, J ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Brazilian; Hyperhomocysteinemia; Methylenetetrahydrofolate reductase; Risk factor; Venous thromboembolism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); HOMOCYSTEINE;

ADOLESCENT; ADULT; AGED; ARTICLE; BRAZIL; CONFIDENCE INTERVAL; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENETIC RISK; GENOTYPE; HUMAN; HYPERHOMOCYSTEINEMIA; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; RISK ASSESSMENT; RISK FACTOR; SCHOOL CHILD; THROMBOPHILIA; VEIN THROMBOSIS;

3' UNTRANSLATED REGIONS; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AMINO ACID SUBSTITUTION; BRAZIL; CHILD; FASTING; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYPERHOMOCYSTEINEMIA; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; MUTATION, MISSENSE; ODDS RATIO; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; POINT MUTATION; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); PROTHROMBIN; RISK FACTORS; THROMBOPHILIA; VENOUS THROMBOSIS;

EID: 0036526239     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001721-200204000-00014     Document Type: Article

References (12)

1. Hyperhomocysteinemia, atherosclerosis and thrombosis
2. High prevalence of hyperhomocyst(e)inemia in patients with juvenile venous thrombosis
3. Intermediate homocysteinemia: A thermolabile variant of methylenetetrahydrofolate reductase
4. A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
5. The mutation Ala677 → VA1 in the methylene tetrahydrofolate reductase gene: A risk factor for arterial disease and venous thrombosis
6. 20210 mutation
7. Thermolabile methylene-tetrahydrofolate reductase and factor V Leiden in the risk of deep-vein thrombosis
8. 12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events
9. Rapid and accurate HPLC assay for plasma total homocysteine and cysteine in a clinical laboratory setting
10. Serum total homocysteine concentrations in adolescent and adult Americans: Results from the third National Health and Nutrition Examination Survey
11. Hyperhomocysteinemia as a risk factor for deep-vein thrombosis
12. Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease. The result of a meta-analysis