Plasma glucagon and free fatty acid responses to a glucose load in the obese spontaneous hypertensive rat (SHROB) model of metabolic syndrome X

Experimental Biology and Medicine

Volumn 227, Issue 3, 2002, Pages 164-170

  Velliquette, Rodney A ^a   Koletsky, Richard J ^a   Ernsberger, Paul ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Free fatty acids; Glucagons; Insulin resistance; Metabolic Syndrome X; Spontaneously hypertensive obese rats

Indexed keywords

FATTY ACID; GLUCAGON; GLUCOSE; INSULIN; LEPTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARATIVE STUDY; DIET RESTRICTION; FATTY ACID BLOOD LEVEL; FEMALE; GENOTYPE; GLUCAGON BLOOD LEVEL; GLUCAGON RELEASE; GLUCOSE INTOLERANCE; HYPERINSULINEMIA; HYPERLIPIDEMIA; HYPERTENSION; INSULIN RESISTANCE; MALE; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; SYNDROME X;

ANIMALIA;

EID: 0036521532     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.1177/153537020222700303     Document Type: Article

References (41)

1. Reaven GM. Role of insulin resistance in human disease. Diabetes 37:1595-1607, 1988.
2. Etgen GL, Oldham BS. Profiling of Zucker diabetic fatty rats in their progression to the overt diabetic state. Metabolism 49:684-688, 2000.
3. Ernsberger P, Ishizuka T, Liu S, Farrell, CJ, Bedol, D, Koletsky RJ, Friedman JE. Mechanisms of antihyperglycemic effects of moxonidine in the obese spontaneously hypertensive Koletsky Rat (SHROB). J Pharm Exp Ther 288:139-147, 1998.
4. Mondon CE, Reaven GM. Evidence of abnormalities of insulin metabolism in rats with spontaneous hypertension. Metabolism 37:303-305, 1989.
5. Kastin AJ, Pan W, Maness LM, Koletsky RJ, Ernsberger P. Decrease transport of leptin across the blood brain barrier in rats lacking the short form of the leptin receptor. Peptides 20:1449-1453, 1999.
6. Lavine RL, Voyles N, Perrino PV, Recant L. The effects of fasting on tissue cyclic AMP and plasma glucagon in the obese hyperglycemic mouse. Endocrinology 97:615-620, 1975.
7. Bryce GF, Johnson PR, Sullivan AC, Stern JS. Insulin and glucagon: plasma levels and pancreatic release in the genetically obese Zucker rat. Horm Metab Res 9:366-370, 1977.
8. Russell JC, Ahuja SK, Manickavel V, Rajotte RV, Amy RM. Insulin resistance and impaired glucose tolerance in the atherosclerosis-prone LA/N corpulent rat. Arteriosclerosis 7:620-626, 1987.
9. Bhathena SJ, Kennedy BW, Jones J, Smith PM, Michaelis OE, Carswell N, Hansen CT, Voyles NR, Recant L. Effects of dietary carbohydrates on insulin and glucagon receptors in a new model of noninsulin-dependent diabetes-SHR/N-Corpulent rat (42957). Proc Soc Exp Biol Med 192:66-71, 1989.
10. Nishikawa K, Ikeda H, Matsuo T. Abnormal glucagon secretion in Zucker fatty rat. Horm Metab Res 13:259-263, 1981.
11. Ellwood KC, Michaelis OE, Emberland JJ, Bhathena SJ. Hormonal and lipogenic and gluconeogenic enzymatic responses in LA/N- Corpulent rats (42079). Proc Soc Exp Biol Med 179:163-167, 1985.
12. Eaton RP, Conway M, Schade DS. Endogenous glucagon regulation in genetically hypolipdemic obese rats. Am J Physiol 230:1336-1341, 1976.
13. Laube H, Fussganger RD, Pfeiffer EF. Paradoxical glucagon release in obese hyperglycemic mice. Horm Metab Res 6:426, 1974.
14. Thorburn A, Litchfield A, Fabris S, Proietto. Abnormal transient rise in hepatic glucose production after oral glucose in non-insulin-dependent diabetic subjects. Diab Res Clin Prac 28:127-135, 1995.
15. Shah P, Vella A, Basu R, Schwenk WF, Rizza RA. Lack of suppression of glucose contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus. J Clin Endocrinol Metabol 85:4035-4039, 2000.
16. Randle PJ, Garland PB, Hales CN, Newsholme EA. The glucose fatty-acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet I:785-789, 1963.
17. Bevilacqua S, Bonadonna R, Buzzigoli G, Boni C, Ciociaro D, Maccari F, Giorico MA, Ferrannini E. Acute elevation of free fatty acid levels leads to hepatic insulin resistance in obese subjects. Metab Clin Exp 36:502-506, 1987.
18. Zhou Y-P, Grill VE. Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 93:870-876, 1994.
19. Gonzalez-Manchon C, Ayuso MS, Parrilla R. Control of hepatic gluconeogensis: role of fatty acid oxidation. Arch Biochem Biophys 271:1-9, 1989.
20. Ernsberger P, Koletsky RJ, Friedman JE. Molecular pathology in the obese spontaneous hypertensive Koletsky rat: a model of syndrome X. Ann NY Acad Sci 892:272-288, 1999.
21. Friedman JE, Ishizuka T, Liu S, Farrell CJ, Koletsky RJ, Bedol D, Ernsberger P. Anti-hyperglycemic activity of moxonidine: metabolic and molecular effects in obese spontaneously hypertensive rats. Bld Pres 7:32-39, 1998.
22. Birnbaumer L, Rodbell M. Adenyl cyclase in fat cells. II. Hormone receptors. J Biol Chem 244:3477-3482, 1969.
23. Carlson MG, Snead WI, Campbell PJ. Regulation of free fatty acid metabolism by glucagon. J Clin Endocrinol Metab 77:11-15, 1993.
24. Wu MS, Jeng CY, Hollenbeck CB, Jaspan J, Reaven GM. Does glucagon increase plasma free fatty acid concentrations in humans with normal glucose tolerance? J Clin Endocrinol Metab 70:410-416, 1990.
25. Flatt Pr, Swanston-Flatt SK, Bailey CJ. Glucagon antiserum: a tool to investigate the role of circulating glucagon in obese-hyperglycemic (ob/ob) mice. Biochem Soc Trans 7:911-913, 1979.
26. Baron AD, Schaeffer L, Shragg P, Kolterman OG. Role of hyperglucagonemia in maintenance of increased rates of hepatic glucose output in type II diabetics. Diabetes 36:274-283, 1987.
27. Samols E, Marri G, Marks V. Promotion of insulin secretion by glucagon. Lancet 2:415-416, 1965.
28. Kawai K, Yakota C, Ohashi S, Watanabe Y, Yamashita K. Evidence that glucagon stimulates insulin secretion through its own receptor in rat. Diabetologia 38:274-276, 1995.
29. Nemecz M, Preininger K, Englisch R, Furnsinn C, Schneider B, Waldhausl W, Roden M. Acute effects of leptin on hepatic glycogenolysis and gluconeogenesis in perfused rat liver. Hepatology 29:166-172, 1999.
30. Zhao AZ, Shinohara MM, Huang D, Shimizu M, Eldar-Finelman H, Krebs EG, Beavo JA, Bornfeldt KE. Leptin induced insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes. J Biol Chem 275:11348-11354, 2000.
31. Haque MS, Minokoshi Y, Hamai M, Iwai M, Horiuchi M, Shimazu T. Role of the sympathetic nervous system and insulin in enhancing glucose uptake in peripheral tissues after intrahypothalamic injection of leptin in rats. Diabetes 48:1706-1712, 1999.
32. Kamohara S, Burcelin R, Halaas JL, Friedman JM, Charron MJ. Acute stimulation of glucose metabolism in mice by leptin treatment. Nature 389:374-377, 1997.
33. Burcelin R, Kamohara S, Li J, Tannenbaum GS, Charron MJ, Friedman JM. Acute intravenous leptin infusion increases glucose turnover but not skeletal muscle glucose uptake in ob/ob mice. Diabetes 48:1264-1269, 1999.
34. Turner SM, Linfoot PA, Neese RA, Hallerstein MK. Effects of leptin on hepatic carbohydrate metabolism in normal and ob/ob mice. Diabetes 47(Suppl 1):1081, 1998
35. McKeigue PM, Laws A, Chen YD, Marnot MG, Reaven GM. Relation of plasma triglyceride and apoB levels to insulin-mediated suppression of nonesterified fatty acids. Arterioscler Thromb 13:1187-1192, 1993.
36. Iannello S, Campione R, Belfiore F. Responses of insulin, glucagon, lactate, and nonesterified fatty acids to glucose in visceral obesity with and without NIDDM: relationship to hypertension. Mol Genet Metab 63:214-223, 1998.
37. Borghi VC, Wajchenberg BL, Cesar FP. Plasma glucagon suppressibility after oral glucose in obese subjects with normal and impaired glucose tolerance. Metabolism 33:1068-1074, 1984.
38. Mitrakou A, Kelly D, Mokan M, Veneman T, Pangburn T, Reilly J, Gerich J. Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. N Engl J Med 326:22-29, 1992.
39. Ubukata E, Mokuda O, Sakamoto Y, Shimizu N. Effects of various glucagon/insulin ratios on blood ketone body levels in rats by use of osmotic minipumps. Diabetes Res Clin Prac 34:1-6 1996.
40. Parrilla R, Goodman MN, Toews CJ. Effects of glucagon: insulin ratios on hepatic metabolism. Diabetes 23:725-731, 1974.
41. Unger RH, Orci L. The role of glucagon in diabetes. Compr Ther 8:53-59, 1982.