Lack of association between depression and loss of neurons in the locus coeruleus in Alzheimer disease

Archives of General Psychiatry

Volumn 56, Issue 1, 1999, Pages 45-51

  Hoogendijk, Witte J G ^a,b,d   Sommer, Iris E C ^b   Pool, Chris W ^a   Kamphorst, Wouter ^c   Hofman, Michel A ^a   Eikelenboom, Piet ^b   Swaab, Dick F ^a  

^a NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c Departments of Pathology   (Netherlands)

^d Valerius Clinic   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOVASCULAR AGENT; DICLOFENAC; FOLIC ACID; INSULIN; NARCOTIC ANALGESIC AGENT; PSYCHOTROPIC AGENT;

AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; COMORBIDITY; CONTROLLED STUDY; DEPRESSION; DISEASE CLASSIFICATION; FEMALE; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; LOCUS CERULEUS; MALE; NERVE CELL DEGENERATION; NEUROPATHOLOGY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CELL COUNT; COMORBIDITY; DEPRESSIVE DISORDER; FEMALE; HUMANS; LOCUS COERULEUS; MALE; NETHERLANDS; NEURONS; SEVERITY OF ILLNESS INDEX;

EID: 0032925953     PISSN: 0003990X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpsyc.56.1.45     Document Type: Article

References (32)

1. Steele C, Rovner B, Chase GA, Folstein M. Psychiatric symptoms and nursing home placement of patients with Alzheimer's disease. Am J Psychiatry. 1990; 147:1049-1051.
2. Nyth AL, Gottfries CG, Lyby K, Smedegaard-Anderson L, Gylding-Sabroe J, Kristensen M, Refsum HE, Ofsti E, Eriksson S, Syverson S. A controlled multicenter clinical study of citalopram and placebo in elderly depressed patients with and without concomitant dementia. Acta Psychiatr Scand. 1992:86:138-145.
3. Naranjo CA, Herrmann N, Mittmann N, Bremner KE. Recent advances in geriatric psychopharmacology. Drugs Aging. 1995;7:184-202.
4. Schildkraut JJ, Schanberg SM, Breese GR, Kopin IJ. Norepinephrine metabolism and drugs used in the affective disorders: a possible mechanism of action Am J Psychiatry. 1967;124:600-608.
5. Van Praag HM. Depression. Lancet. 1982;2:1259-1264.
6. Hankolf LD, Peress NS. Neuropathology of the brain stem in psychiatric disorders. Biol Psychiatry. 1981;16:945-952.
7. Klimek V, Stockmeier C, Overholser J, Meltzer HY, Kalka S, Dilley G, Ordway GA. Reduced levels of norepinephrine transporters in the locus coeruleus in major depression. J Neurosci. 1997;17:8451-8458.
8. Zubenko GS, Moossy J. Major depression in primary dementia: clinical and neuropathological correlates. Arch Neurol. 1988:45:1182-1186.
9. Förstl H, Bums A, Luthert P, Cairns N, Lantos P, Levy R. Clinical and neuropathological correlates of depression in Alzheimer's disease. Psychol Med. 1992:22:877-884.
10. Zweig RM. Ross CA, Hedreen JC, Steele C, Cardillo JE, Whitehouse PJ, Folstein MF, Price DL. The neuropathology of aminergic nuclei in Alzheimer's disease. Ann Neurol. 1988;24:233-242.
11. McKhann G, Drachman D, Foistein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34:939-944.
12. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM. Vogel FS. Hughes JP, Van Belle G, Berg L. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD), II: standardization of the neuropathologic assessment of Alzheimer's disease. Neurology. 1991;41:479-486.
13. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Revised Third Edition. Washington, DC: American Psychiatric Association: 1987.
14. Hamilton M. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol. 1967;6:278-296.
15. Alexopoulos GS, Abrams RC, Young RC, Shamoian CA. Cornell Scale for Depression in Dementia. Biol Psychiatry. 1988;23:271-284.
16. Claman DL, Radebaugh TS. Neuropsychological assessment in clinical trials of Alzheimer's disease. Alzheimer Dis Assoc Disord. 1991;5(suppl 1):S49-S56.
17. Alexopoulos GS. The treatment of depressed demented patients. J Clin Psychiatry. 1996;57(suppl 14):14-20.
18. Reisberg B, Ferris SH, De Leon MJ, Crook T. Global Deterioration Scale (GDS). Psychopharmacol Bull. 1988;24:661-663.
19. Reisberg B. Functional assessment staging (FAST). Psychopharmacol Bull. 1988; 24:653-659.
20. German DC, Manaye KF, White CL, Woodward DJ, McIntire DD, Smith WK, Kalaria RN, Mann DM. Disease-specific patterns of locus coeruleus cell loss. Ann Neurol. 1992;32:667-676.
21. Lohr JB, Jeste DV. Locus ceruleus morphometry in aging and schizophrenia. Acta Psychiatr Scand. 1988;77:689-697.
22. Vijayashankar N, Brody H. A quantitative study of the pigmented neurons in the nuclei locus coeruleus and subcoeruleus in man as related to aging. J Neuropathol Exp Neurol. 1979;38:490-497.
23. Mouton PR, Pakkenberg B, Gundersen HJ, Price DL. Absolute number and size of pigmented locus coeruleus neurons in young and aged individuals. J Chem Neuroanat. 1994;7:185-190.
24. Braak H, Braak E, Yilmazer D, Vos RA, Jansen EN, Bohl J. Pattern of brain destruction in Parkinson's and Alzheimer's disease. J Neural Transm. 1996;103:455-490.
25. Chan-Palay V, Asan E. Quantitation of catecholamine neurons in the locus coeruleus in human brains of normal young and older adults and in depression. J Comp Neurol. 1989;287:357-372.
26. Hoogendijk WJG, Pool ChW, Troost D, Van Zwieten E, Swaab DF. Image analyser-assisted morphometry of the locus coeruleus in Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Brain. 1995;118:131-143.
27. Burke WJ, Rubin EH, Morris JC, Berg L. Symptoms of "depression" in dementia of the Alzheimer type. Alzheimer Dis Assoc Disord. 1988;2:356-362.
28. Jellinger K. Neuropathological substrates of Alzheimer's disease and Parkinson's disease. J Neural Transm. 1987;(suppl 24):109-129.
29. Arango V, Underwood MD, Mann JJ. Fewer pigmented locus coeruleus neurons in suicide victims: preliminary results. Biol Psychiatry. 1996;39:112-120.
30. Zweig RM, Cardillo JE, Cohen M, Giere S, Hedreen JC. The locus ceruleus and dementia in Parkinson's disease. Neurology. 1993;43:986-991.
31. Gottfries CG, Adolfsson R, Aquilonius SM, Carlsson A, Eckernas SA, Nordberg A, Oreland L, Svennerholm L, Wiberg A, Winblad B. Biochemical changes in dementia disorders of Alzheimer type (AD/SDAT). Neurobiol Aging. 1983;4:261-271.
32. Esiri MM. The basis for behavioural disturbances in dementia. J Neurol Neurosurg Psychiatry. 1996;61:127-130.