Evidence for the murine IgH μ locus acting as a hot spot for intrachromosomal homologous recombination

Journal of Immunology

Volumn 168, Issue 5, 2002, Pages 2332-2339

  Raynard, Steven J ^a   Read, Leah R ^a   Baker, Mark D ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; IMMUNOGLOBULIN HEAVY CHAIN;

ALLELE; ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; CROSSING OVER; DNA REPAIR; EVOLUTION; GENE LOCUS; GENETIC CONSERVATION; GENETIC MARKER; GENETIC RECOMBINATION; GENETIC VARIABILITY; HOMOLOGOUS RECOMBINATION; MITOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0036499183     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.5.2332     Document Type: Article

References (59)

1. Recombination in yeast
2. Programmed gene rearrangements altering gene expression
3. Genomic disorders: Structural features of the genome can lead to DNA rearrangements and human disease traits
4. Loss of constitutional heterozygosity in human cancer
5. The organization, expression, and evolution of antibody genes and other multigene families
6. Gene conversion: Some implications for immunoglobulin genes
7. Arrangement and evolution of eukaryotic genes
8. Intergenic conversion and reiterated genes
9. Human fetal Gγ and Aγ-globin genes: Complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes
10. Somatic diversification of IgH genes in rabbit
11. Rearrangement of immunoglobulin genes in chicken B cell development
12. H genes: A role in gene interaction?
13. Evidence supporting somatic assembly of the DNA segments (minigenes), coding for the framework, and complementarity-determining segments of immunoglobulin variable regions
14. Evidence indicating independent assortment of framework and complementarity-determining segments of the variable regions of rabbit light chains: Delineation of a possible J minigene
15. Antibody diversity: Something for everyone
16. Recombination between antibody heavy chain variable-region genes: Evidence for gene conversion
17. Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes
18. Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP
19. Immunoglobulin V region variants in hybridoma cells. I. Isolation of a variant with altered idiotypic and antigen binding specificity
20. Germ line variable regions that match hypermutated sequences in genes encoding murine anti-hapten antibodies
21. High-frequency homologous recombination between duplicate chromosomal immunoglobulin μ heavy-chain constant regions
22. Immunoglobulin D switching can occur through homologous recombination in human B cells
23. Class switch from μ to δ is mediated by homologous recombination between σμ and Σμ sequences in human immunoglobulin gene loci
24. Nucleotide sequence of an unequal sister chromatid exchange site in a mouse myeloma cell line
25. Cell-cycle-regulated DNA double-strand breaks in somatic hypermutation of immunoglobulin genes
26. Somatic recombination of heavy chain variable region transgenes with the endogenous immunoglobulin heavy chain locus in mice
27. Somatic generation of hybrid antibody H chain genes in transgenic mice via interchromosomal gene conversion
28. Analysis of sequence transfers resembling gene conversion in a mouse antibody transgene
29. Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes
30. High-frequency homologous recombination between duplicate chromosomal immunoglobulin μ heavy-chain constant regions
31. High-frequency gene conversion between repeated Cμ sequences integrated at the chromosomal immunoglobulin μ locus in mouse hybridoma cells
32. Homologous recombination between repeated chromosomal sequences in mouse cells
33. Homologous recombination between defective neo genes in mouse 3T6 cells
34. Recombination events after transient infection and stable integration of DNA into mouse cells
35. Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells
36. Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells
37. Targeted homologous recombination in mammalian cells
38. Immunoglobulin M mutants
39. Deletions in immunoglobulin μ chains
40. Homologous recombination can restore normal immunoglobulin production in a mutant hybridoma cell line
41. Analysis of mutations introduced into the chromosomal immunoglobulin μ gene
42. Functional immunoglobulin M production after transfection of cloned immunoglobulin heavy and light chain genes into lymphoid cells
43. High efficiency, site-specific modification of the chromosomal immunoglobulin locus by gene targeting
44. Mechanisms of double-strand-break repair during gene targeting in mammalian cells
45. Site-directed mutagenesis of virtually any plasmid by eliminating a unique site
46. Sequence of the gene for the constant region of the μ chain of BALB/c mouse immunoglobulin
47. Use of a small palindrome genetic marker to investigate mechanisms of double-strand-break repair in mammalian cells
48. Stimulation and suppression of PCR-mediated recombination
49. In vivo biochemistry: Physical monitoring of recombination induced by site-specific endonucleases
50. Genetic manipulation of genomes with rare-cutting endonucleases
51. cis-acting, recombination-stimulating activity in a fragment of the ribosomal DNA of S. cerevisiae
52. Elevated recombination rates in transcriptionally active DNA
53. Transcriptional induction of Ty recombination in yeast
54. Transcription enhances intrachromosomal homologous recombination in mammalian cells
55. Hot spots of homologous recombination
56. DNA-binding protein RAP1 stimulates meiotic recombination at the HIS4 locus in yeast
57. Combinatorial regulation of transcription. II. The immunoglobulin μ heavy chain gene
58. Immunoglobulin gene transcription