High-performance liquid chromatographic assay for N-glucuronidation of nicotine and cotinine in human liver microsomes

Analytical Biochemistry

Volumn 302, Issue 1, 2002, Pages 131-135

  Nakajima, Miki ^a   Kwon, Jun Tack ^a   Tanaka, Eriko ^a   Yokoi, Tsuyoshi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COLUMN CHROMATOGRAPHY; GLUCOSE; ION CHROMATOGRAPHY; MIXTURES; NICOTINE;

BIOLOGICAL SPECIMENS; COEFFICIENT OF VARIATION; HUMAN LIVER MICROSOMES; INTER-ASSAY PRECISION; INTRA-ASSAY PRECISION; ION-PAIR CHROMATOGRAPHY; LIMIT OF QUANTIFICATIONS; LIQUID CHROMATOGRAPHIC ASSAY;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

COTININE; DRUG METABOLITE; GLUCURONIDE; NICOTINE; URIDINE DIPHOSPHATE GLUCURONIC ACID;

ACCURACY; ARTICLE; BIOASSAY; DRUG GLUCURONIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; ION PAIR CHROMATOGRAPHY; LIVER MICROSOME; PRIORITY JOURNAL;

EID: 0036498773     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1006/abio.2001.5528     Document Type: Article

References (20)

1. Role of human cytochrome P4502A6 in C-oxidation of nicotine
2. Trans-3′-hydroxycotinine as a main metabolite in urine of smokers
3. The determination of nicotine and cotinine in plasma
4. Disposition of nicotine and eight metabolites in smokers and nonsmokers: Identification in smokers of two metabolites that are longer lived than cotinine
5. trans-3′-Hydroxycotinine: A main metabolite in smokers
6. Nicotine metabolic profile in man: Comparison of cigarette smoking and transdermal nicotine
7. Evidence for urinary excretion of glucuronide conjugates of nicotine, cotinine, and trans-3′-hydroxycotinine in smokers
8. Ethnic differences in N-glucuronidation of nicotine and cotinine
9. Determination of nicotine and its main metabolites in urine by high-performance liquid chromatography
10. Synthesis of S-(-)-nicotine N-glucuronide and direct separation of nicotine-derived conjugates using high-performance liquid chromatography
11. Characterization of the glucuronide conjugate of cotinine: A previously unidentified major metabolite of nicotine in smoker's urine
12. Direct determination of cotinine-N-glucuronide in urine using thermospray liquid chromatography/mass spectrometry
13. Evidence for the biosynthesis of a glucuronide conjugate of (S)-(-)-nicotine, but not (S)-(-)-cotinine or (±)-trans-3′-hydroxycotinine by marmoset hepatic microsomes
14. Drug glucuronidation in humans
15. Glucuronidation of drugs: A re-evaluation of the pharmacological significance of the conjugates and modulating factors
16. Human UDP-glucuronosyltransferases: Metabolism, expression, and disease