Studies on cerebral protective agents. IX. Synthesis of novel 1,2,3,4-tetrahydroisoquinolines as N-methyl-D-aspartate antagonists

Chemical and Pharmaceutical Bulletin

Volumn 44, Issue 1, 1996, Pages 95-102

  Ohkubo, Mitsuru ^a   Kuno, Atsushi ^a   Katsuta, Kiyotaka ^a   Ueda, Yoshiko ^a   Shirakawa, Kiyoharu ^a   Nakanishi, Hajime ^a   Nakanishi, Isao ^a   Kinoshita, Takayoshi ^a   Takasugi, Hisashi ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

1,2,3,4 tetrahydroisoquinoline; FR115427; N methyl D aspartate antagonist; Structure activity relationship

Indexed keywords

1,2,3,4 TETRAHYDRO 1 METHYL 1 PHENYLISOQUINOLINE; DIZOCILPINE; FR 115427; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN HYPOXIA; BRAIN PROTECTION; CONVULSION; DRUG CONFORMATION; DRUG EFFECT; DRUG SYNTHESIS; HIPPOCAMPUS; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NERVE DEGENERATION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANOXIA; ANTICONVULSANTS; BRAIN ISCHEMIA; CRYSTALLOGRAPHY, X-RAY; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; HIPPOCAMPUS; ISOQUINOLINES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, INBRED ICR; MOLECULAR STRUCTURE; NEUROPROTECTIVE AGENTS; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; SEIZURES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 0030055830     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.44.95     Document Type: Article

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