Small bowel disease in the elderly: Diarrhoea and malabsorption

Bailliere's Best Practice and Research in Clinical Gastroenterology

Volumn 16, Issue 1, 2002, Pages 17-36

  Hoffmann, Jörg C ^a,c   Zeitz, Martin ^b,c  

^a German IBD Network   (Germany)

^b Department of Medicine ^*

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Bacterial overgrowth; Chronic diarrhoea; Complications of diarrhoea; Drug induced diarrhoea; Infectious diarrhoea

Indexed keywords

ANALGESIC AGENT; ANTIBIOTIC AGENT; ANTIDIARRHEAL AGENT; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; AURANOFIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CHENODEOXYCHOLIC ACID; COLCHICINE; CYANOCOBALAMIN; DIGOXIN; ERGOT ALKALOID; FOLIC ACID; HISTAMINE H2 RECEPTOR ANTAGONIST; IMMUNOSUPPRESSIVE AGENT; INFUSION FLUID; LEVOTHYROXINE; MEDIUM CHAIN FATTY ACID; METRONIDAZOLE; MISOPROSTOL; MORPHINE; NEOMYCIN; NONSTEROID ANTIINFLAMMATORY AGENT; OLSALAZINE; ORAL REHYDRATION SOLUTION; PENICILLAMINE; PROTON PUMP INHIBITOR; TRACE ELEMENT; UNINDEXED DRUG; VITAMIN;

AGE; ANAMNESIS; ANEMIA; BACTERIAL OVERGROWTH; CAUSE OF DEATH; CELIAC DISEASE; CLINICAL FEATURE; CROHN DISEASE; DEVELOPED COUNTRY; DIAGNOSTIC PROCEDURE; DIARRHEA; DISEASE DURATION; DISEASE SEVERITY; DRUG USE; ENTEROPATHY; FECES CULTURE; HUMAN; HYPOTENSION; IMMUNE DEFICIENCY; INTESTINE INFECTION; INTESTINE MOTILITY; MALABSORPTION; MORBIDITY; MORTALITY; MULTIPLE ORGAN FAILURE; NEUROLOGIC DISEASE; ORAL REHYDRATION THERAPY; OSTEOPOROSIS; OUTPATIENT; REVIEW; SKIN MANIFESTATION; SMALL INTESTINE DISEASE; SMALL INTESTINE TUMOR; WEIGHT REDUCTION; ABDOMINAL PAIN; AGING; COMORBIDITY; DRUG INDUCED DISEASE; FLUID THERAPY; IMMUNOLOGY; AGED; INTESTINE ABSORPTION; PATHOPHYSIOLOGY; SMALL INTESTINE;

AGED; AGING; DIARRHEA; HUMANS; INTESTINAL ABSORPTION; INTESTINE, SMALL; MALABSORPTION SYNDROMES;

EID: 0036482830     PISSN: 15216918     EISSN: None     Source Type: Journal    
DOI: 10.1053/bega.2002.0263     Document Type: Article

References (71)

1. Hohn P Gabbert H & Wagner R 1978 Differentiation and aging of the rat intestinal mucosa. II. Morphological, enzyme histochemical and disc electrophoretic aspects of the ageing of the small intestinal mucosa. Mechanisms of Ageing and Development, 7 217-226.
2. Lipski PS Bennett MK Kelly PJ & James OF 1992 Ageing and duodenal morphometry. Journal of Clinical Pathology, 45 450-452.
3. Corazza GR Frazzoni M Gatto MR & Gasbarrini G 1986 Ageing and small-bowel mucosa: a morphometric study. Gerontology, 32 60-65.
4. Webster SG & Leeming JT 1975 The appearance of the small bowel mucosa in old age. Age and Ageing, 4 168-174.
5. Warren PM Pepperman MA & Montgomery RD 1978 Age changes in small-intestinal mucosa. Lancet, 2 849-850.
6. Santer RM & Baker DM 1988 Enteric neuron numbers and sizes in Auerbach's plexus in the small and large intestine of adult and aged rats. Journal of the Autonomic Nervous System, 25 59-67.
7. Feibusch JM & Holt PR 1982 Impaired absorptive capacity for carbohydrate in the aging human. Digestive Diseases and Sciences, 27 1095-1100.
8. Ferraris RP 1997 Effect of aging and caloric restriction on intestinal sugar and amino acid transport. Frontiers in Bioscience, 2 e108-115.
9. Birlouez-Aragon I Ravelontseheno L Villate-Cathelineau B Cathelineau G & Abitbol G 1993 Disturbed galactose metabolism in elderly and diabetic humans is associated with cataract formation. Journal of Nutrition, 123 1370-1376.
10. Ferraris RP & Vinnakota RR 1993 Regulation of intestinal nutrient transport is impaired in aged mice. Journal of Nutrition, 123 502-511.
11. Lee MF Russell RM Montgomery RK & Krasinski SD 1997 Total intestinal lactase and sucrase activities are reduced in aged rats. Journal of Nutrition, 127 1382-1387.
12. Simko V & Michael S 1989 Absorptive capacity for dietary fat in elderly patients with debilitating disorders. Archives of Internal Medicine, 149 557-560.
13. Said HM & Hollander D 1984 Does aging affect the intestinal transport of 5-methyltetrahydrofolate?. Digestion, 30 231-235.
14. 12 absorption from the gut does not decline with age in normal elderly humans. Age and Ageing, 11 180-183.
15. Nilsson-Ehle H Landahl S Lindstedt G et al. 1989 Low serum cobalamin levels in a population study of 70- and 75-year-old subjects. Gastrointestinal causes and hematological effects. Digestive Diseases and Sciences, 34 716-723.
16. 2 in elderly subjects. Journal of Clinical Endocrinology and Metabolism, 63 656-660.
17. Kinyamu HK Gallagher JC Balhorn KE Petranick KM & Rafferty KA 1997 Serum vitamin D metabolites and calcium absorption in normal young and elderly free-living women and in women living in nursing homes. American Journal of Clinical Nutrition, 65 790-797.
18. Kassarjian Z & Russell RM 1989 Hypochlorhydria: a factor in nutrition. Annual Review of Nutrition, 9 271-285.
19. Bullamore JR Wilkinson R Gallagher JC Nordin BE & Marshall DH 1970 Effect of age on calcium absorption. Lancet, 2 535-537.
20. Fich A Camilleri M & Phillips SF 1989 Effect of age on human gastric and small bowel motility. Journal of Clinical Gastroenterology, 11 416-420.
21. Saltzman JR Kowdley KV Perrone G & Russell RM 1995 Changes in small-intestine permeability with aging. Journal of the American Geriatrics Society, 43 160-164.
22. Penn ND Purkins L Kelleher J Heatley RV & Mascie-Taylor BH 1991 Ageing and duodenal mucosal immunity. Age and Ageing, 20 33-36.
23. Riordan SM McIver CJ Wakefield D et al. 1996 Luminal immunity in small-intestinal bacterial overgrowth and old age. Scandinavian Journal of Gastroenterology, 31 1103-1109.
24. Schneider T Stallmach A & Zeitz M 1995 [The effect of aging on the intestinal immune system. Mucosal immunosenescence]. Internist (Berlin), 36 648-655.
25. Arranz E O'Mahony S Barton JR & Ferguson A 1992 Immunosenescence and mucosal immunity: significant effects of old age on secretory IgA concentrations and intraepithelial lymphocyte counts. Gut, 33 882-886.
26. Kawanishi H & Kiely J 1989 Immune-related alterations in aged gut-associated lymphoid tissues in mice. Digestive Disease and Sciences, 34 175-184.
27. Powell DW 1995 Approach to the patient with diarrhea. In T Yamada (Ed.), Textbook of Gastroenterology, 813-863. Philadelphia: J. B. Lippincott Company.
28. Farthing MJ 2000 Diarrhoea: a significant worldwide problem. Intemational Journal of Antimicrobial Agents, 14 65-69.
29. Gangarosa RE Glass RI Lew JF & Boring JR 1992 Hospitalizations involving gastroenteritis in the United States, 1985: the special burden of the disease among the elderly. American Journal of Epidemiology, 135 281-290.
30. Lew JF Glass RI Gangarosa RE et al. 1991 Diarrheal deaths in the United States, 1979 through 1987. A special problem for the elderly. Journal of the American Medical Association, 265 3280-3284.
31. Guerrant RL Van Gilder T Steiner TS et al. 2001 Practice guidelines for the management of infectious diarrhea. Clinical Infectious Diseases, 32 331-351.
32. Buzby JC & Roberts T 1997 Economic costs and trade impacts of microbial foodborne illness. World Health Statistics Quarterly, 50 57-66.
33. Holt PR 1990 Diarrhea and malabsorption in the elderly. Gastroenterology Clinics of North America, 19 345-359.
34. WHO. The Management and Prevention of Acute Diarrhoea: Practical Guidelines, 3d edn. Geneva, WHO, 1993
35. Hennessy TW Hedberg CW Slutsker L et al. 1996 A national outbreak of Salmonella enteritidis infections from ice cream. The Investigation Team. New England Journal of Medicine, 334 1281-1286.
36. Edes TE Walk BE & Austin JL 1990 Diarrhea in tube-fed patients: feeding formula not necessarily the cause. American Journal of Medicine, 88 91-93.
37. Lewis BS Kornbluth A & Waye JD 1991 Small bowel tumours: yield of enteroscopy. Gut, 32 763-765.
38. Hoffmann JC & Zeitz M 2000 Treatment of Crohn's disease. Hepatogastroenterology, 47 90-100.
39. Nagar A & Roberts IM 1999 Small bowel diseases in the elderly. Clinics in Geriatric Medicine, 15 473-486.
40. Brasitus TA & Sitrin MD 1990 Intestinal malabsorption syndromes. Annual Review of Medicine, 41 339-347.
41. Montgomery RD Haeney MR Ross IN et al. 1978 The ageing gut: a study of intestinal absorption in relation to nutrition in the elderly. Quarterly Journal of Medicine, 47 197-224.
42. Montgomery RD Haboubi NY Mike NH Chesner IM & Asquith P 1986 Causes of malabsorption in the elderly. Age and Ageing, 15 235-240.
43. Bistrian BR Blackburn GL Vitale J Cochran D & Naylor J 1976 Prevalence of malnutrition in general medical patients. Journal of the American Medical Association, 235 1567-1570.
44. 2 receptor antagonists on the intestinal absorption of folic acid. Journal of Laboratory and Clinical Medicine, 112 458-463.
45. Nordin BE Need AG Steurer T et al. 1998 Nutrition, osteoporosis, and aging. Annals of the New York Academy of Sciences, 854 336-351.
46. Suhr O Danielsson A & Steen L 1992 Bile acid malabsorption caused by gastrointestinal motility dysfunction? An investigation of gastrointestinal disturbances in familial amyloidosis with polyneuropathy. Scandinavian Journal of Gastroenterology, 27 201-207.
47. Webster SG & Leeming JT 1975 Assessment of small bowel function in the elderly using a modified xylose tolerance test. Gut, 16 109-113.
48. Kepczyk T & Kadakia SC 1995 Prospective evaluation of gastrointestinal tract in patients with iron-deficiency anemia. Digestive Diseases and Sciences, 40 1283-1289.
49. Williams AJ Merrick MV & Eastwood MA 1991 Idiopathic bile acid malabsorption - a review of clinical presentation, diagnosis, and response to treatment. Gut, 32 1004-1006.
50. Ratnaike RN & Jones TE 1998 Mechanisms of drug-induced diarrhoea in the elderly. Drugs and Aging, 13 245-253.
51. Ehrenfeld M Levy M Sharon P Rachmilewitz D & Eliakim M 1982 Gastrointestinal effects of long-term colchicine therapy in patients with recurrent polyserositis (familial mediterranean fever). Digestive Diseases and Sciences, 27 723-727.
52. Stillman AE Weinberg M Mast WC & Palpant S 1977 Ischemic bowel disease attributable to ergot. Gastroenterology, 72 1336-1337.
53. Bjarnason I Zanelli G Prouse P et al. 1987 Blood and protein loss via small-intestinal inflammation induced by non-steroidal anti-inflammatory drugs. Lancet, 2 711-714.
54. Bjarnason I Hayllar J MacPherson AJ & Russell AS 1993 Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. Gastroenterology, 104 1832-1847.
55. Madhok R MacKenzie JA Lee FD et al. 1986 Small bowel ulceration in patients receiving non-steroidal anti-inflammatory drugs for rheumatoid arthritis. Quarterly Journal of Medicine, 58 53-58.
56. Levi S de Lacey G Price AB et al. 1990 'Diaphragm-like' strictures of the small bowel in patients treated with non-steroidal anti-inflammatory drugs. British Journal of Radiology, 63 186-189.
57. Wilson JM Melvin DB Gray GF & Thorbjarnarson B 1974 Primary malignancies of the small bowel: a report of 96 cases and review of the literature. Annals of Surgery, 180 175-179.
58. Wilson JM Melvin DB Gray G & Thorbjarnarson B 1975 Benign small bowel tumor. Annals of Surgery, 181 247-250.
59. Rahman Q Haboubi NY Hudson PR Lee GS & Shah IU 1991 The effect of thyroxine on small intestinal motility in the elderly. Clinical Endocrinology, 35 443-446.
60. Iber FL Parveen S Vandrunen M et al. 1993 Relation of symptoms to impaired stomach, small bowel, and colon motility in long-standing diabetes. Digestive Diseases and Sciences, 38 45-50.
61. Camilleri M & Malagelada JR 1984 Abnormal intestinal motility in diabetics with the gastroparesis syndrome. European Journal of Clinical Investigation, 14 420-427.
62. D'Costa DF Price DE & Burden AC 1992 Diabetic neuropathic cachexia associated with malabsorption. Diabetic Medicine, 9 203-205.
63. Roberts SH James O & Jarvis EH 1977 Bacterial overgrowth syndrome without 'blind loop': a cause for malnutrition in the elderly. Lancet, 2 1193-1195.
64. McEvoy A Dutton J & James OF 1983 Bacterial contamination of the small intestine is an important cause of occult malabsorption in the elderly. British Medical Journal, 287 789-793.
65. Riordan SM McIver CJ Wakefield D et al. 1997 Small intestinal bacterial overgrowth in the symptomatic elderly. American Journal of Gastroenterology, 92 47-51.
66. Haboubi NY & Montgomery RD 1992 Small-bowel bacterial overgrowth in elderly people: clinical significance and response to treatment. Age and Ageing, 21 13-19.
67. Holt PR Rosenberg IH & Russell RM 1989 Causes and consequences of hypochlorhydria in the elderly. Digestive Diseases and Sciences, 34 933-937.
68. Lipski PS Kelly PJ & James OF 1992 Bacterial contamination of the small bowel in elderly people: is it necessarily pathological?. Age and Ageing, 21 5-12.
69. Husebye E Skar V Hoverstad T & Melby K 1992 Fasting hypochlorhydria with gram positive gastric flora is highly prevalent in healthy old people. Gut, 33 1331-1337.
70. Saltzman JR Kowdley KV Pedrosa MC et al. 1994 Bacterial overgrowth without clinical malabsorption in elderly hypochlorhydric subjects. Gastroenterology, 106 615-623.
71. Holt PR 1995 Approach to gastrointestinal problems in the elderly. In T Yamada (Ed.), Textbook of Gastroenterology, 968-988. Philadelphia: J. B. Lippincott.