Chimaeric gonadotropin-releasing hormone (GnRH) peptides with improved affinity for the catfish (Clarias gariepinus) GnRH receptor

Biochemical Journal

Volumn 361, Issue 3, 2002, Pages 515-523

  Blomenröhr, Marion ^a   Ter Laak, Ton ^a   Kühne, Ronald ^a   Beyermann, Michael ^a   Hund, Eveline ^a   Bogerd, Jan ^a   Leurs, Rob ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Computational modelling; G protein coupled receptor; Ligand selectivity; Site directed mutagenesis

Indexed keywords

COLLAGEN; HORMONES;

LIGANDS;

BIOCHEMICAL ENGINEERING;

ALANINE; ARGININE; ASPARAGINE; ASPARTIC ACID; G PROTEIN COUPLED RECEPTOR; GLUTAMIC ACID; GONADORELIN DERIVATIVE; GONADORELIN RECEPTOR; LEUCINE; TRYPTOPHAN; TYROSINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CATFISH; CHICKEN; CONTROLLED STUDY; GOLDFISH; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; MAMMAL; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY;

ALANINE; ANIMALS; ASPARTIC ACID; BINDING SITES; CATFISHES; CELL LINE; CELL MEMBRANE; CHICKENS; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLUTAMIC ACID; GONADOTROPIN-RELEASING HORMONE; HUMANS; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, LHRH; RECOMBINANT FUSION PROTEINS; TRANSFECTION; TRYPTOPHAN; TYROSINE;

CARASSIUS AURATUS; CATFISH; CLARIAS; CLARIAS GARIEPINUS; GALLUS GALLUS; MAMMALIA; VERTEBRATA;

EID: 0036471926     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3610515     Document Type: Article

References (21)

1. Gonadotropin secretion and its control
2. Molecular biology of gonadotropin-releasing hormone and the gonadotropin-releasing hormone receptor
3. Primary structure and function of three gonadotropin-releasing hormones, including a novel form, from an ancient teleost, herring
4. Second gene for gonadotropin-releasing hormone in humans
5. Two gonadotropin-releasing hormones from African catfish (Clarias gariepinus)
6. Glutamate 301 of the mouse gonadotropin-releasing hormone receptor confers specificity for arginine 8 of mammalian gonadotropin-releasing hormone
7. 102 of the gonadotropin releasing hormone receptor is a critical determinant of potency for agonists containing C-terminal glycinamide
8. Molecular mechanisms of ligand interaction with the gonadotropin-releasing hormone receptor
9. Chimeric analogues of vertebrate gonadotropin-releasing hormones comprising substitutions of the variant amino acids in position 5, 7, and 8
10. Two gonadotropin-releasing hormones in the African catfish, Clarias gariepinus: Localization, pituitary receptor binding, and gonadotropin release activity
11. Differences in structure-function relations between nonmammalian and mammalian gonadotropin-releasing hormone receptors
12. Distinct efficacies for two endogenous ligands on a single cognate gonadoliberin receptor
13. A single point slight alteration set as a tool for structure-activity relationship studies of ovine corticotropin releasing factor
14. GnRH receptors with intracellular carboxyl terminal tails undergo acute desensitization of total inositol phosphate production and exhibit accelerated internalization kinetics
15. 11-coupled neuropeptide receptors: The GnRH receptor
16. An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein coupled receptors
17. Residues within transmembrane helices 2 and 5 of the human gonadotropin-releasing hormone receptor contribute to agonist and antagonist binding
18. Irreversible activation of the gonadotropin-releasing hormone receptor by photoaffinity cross-linking: Localization of attachment site to Cys residue in N-terminal segment
19. A locus of the gonadotropin-releasing hormone receptor that differentiates agonist and antagonist binding sites
20. Two gonadotropin-releasing hormone receptor subtypes with distinct ligand selectivity and differential distribution in brain and pituitary in the goldfish (Carassius auratus)
21. Plasticity in the structural and functional evolution of GnRH: A peptide for all seasons