Possible association of QTc interval prolongation with co-administration of quetiapine and lovastatin

Biological Psychiatry

Volumn 51, Issue 3, 2002, Pages 264-265

  Furst, Benjamin A ^a   Champion, Katherine M ^b   Pierre, Joseph M ^a,b   Wirshing, Donna A ^a,b   Wirshing, William C ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

Dyslipidemia; Lovastatin; QTc prolongation; Quetiapine; Schizophrenia; Weight

Indexed keywords

ATORVASTATIN; CYTOCHROME P450 3A4; FLUINDOSTATIN; MEVINOLIN; NICOTINIC ACID; OLANZAPINE; PRAVASTATIN; QUETIAPINE; RISPERIDONE; SERTRALINE; SIMVASTATIN; THIORIDAZINE; ZIPRASIDONE;

ADULT; ARTICLE; CASE REPORT; CLINICAL FEATURE; COMPETITIVE INHIBITION; DISEASE COURSE; DOSE RESPONSE; DRUG BLOOD LEVEL; DYSLIPIDEMIA; FEMALE; HUMAN; PRIORITY JOURNAL; QT INTERVAL; SCHIZOPHRENIA;

ANTICHOLESTEREMIC AGENTS; ANTIPSYCHOTIC AGENTS; CYTOCHROME P-450 ENZYME SYSTEM; DIBENZOTHIAZEPINES; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; HYPERLIPIDEMIAS; LONG QT SYNDROME; LOVASTATIN; MIDDLE AGED; MIXED FUNCTION OXYGENASES; SCHIZOPHRENIA; TIME FACTORS; TRIGLYCERIDES;

EID: 0036468699     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(01)01333-6     Document Type: Article

References (12)

1. HMG-CoA reductase inhibitors: Assessing difference in drug interactions and safety profiles
2. Quetiapinem: A review of its safety in the management of schizophrenia
3. Comparative tolerability of the HMG-CoA reductase inhibitors
4. QT interval prolongation associated with quetiapine (Seroquel) overdose
5. Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors. Similarities and differences
6. Antipsychotic metabolic effects: Weight gain, diabetes mellitus, and lipid abnormalities
7. Clinically relevant pharmacology of selective serotonin reuptake inhibitors. An overview with emphasis on pharmacokinetics and effects on oxidative drug metabolism
8. New-onset diabetes mellitus associated with quetiapine
9. QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients
10. Antipsychotic agents and QT changes