Linear closed mini DNA generated by the prokaryotic cleaving-joining enzyme TelN is functional in mammalian cells

Journal of Molecular Medicine

Volumn 80, Issue 10, 2002, Pages 648-654

  Heinrich, Jochen ^a   Schultz, Jan ^a   Bosse, Magnus ^a   Ziegelin, Günter ^b   Lanka, Erich ^b   Moelling, Karin ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

Author keywords

Interleukin 12; Linear closed DNA; Melanoma; Naked DNA; Protelomerase

Indexed keywords

GREEN FLUORESCENT PROTEIN; INTERLEUKIN 12; PLASMID DNA; PROTELOMERASE TELN; RESTRICTION ENDONUCLEASE; TELOMERASE; UNCLASSIFIED DRUG; ENZYME PRECURSOR; PHOTOPROTEIN; PROTELOMERASE PROTEIN, BACTERIOPHAGE N15; VIRUS DNA; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIOPHAGE; BIOLOGICAL MODEL; CONTROLLED STUDY; DNA CLEAVAGE; DNA FLANKING REGION; DNA SEQUENCE; EMBRYO CELL; ENZYME MECHANISM; GENETIC CODE; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; IN VIVO STUDY; INJECTION; METASTASIS INHIBITION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROKARYOTE; PROTEIN EXPRESSION; ANIMAL; C57BL MOUSE; CELL LINE; CHEMICAL STRUCTURE; COLIPHAGE; ENZYMOLOGY; GENETIC ENGINEERING; GENETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; PLASMID;

ANIMALS; BASE SEQUENCE; CELL LINE; CLONING, MOLECULAR; COLIPHAGES; DNA, VIRAL; ENZYME PRECURSORS; GENETIC ENGINEERING; GREEN FLUORESCENT PROTEINS; INTERLEUKIN-12; LUMINESCENT PROTEINS; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PLASMIDS; TELOMERASE; VIRAL PROTEINS;

EID: 0036460055     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-002-0362-2     Document Type: Article

References (17)

1. Gurunathan S, Klinman DM, Seder RA (2000) DNA vaccines: Immunology, application, and optimization. Annu Rev Immunol 18:927-974
2. Li S, Ma Z (2001) Nonviral gene therapy. Curr Gene Ther 1:201-226
3. Krieg AM, Wagner H (2000) Causing a commotion in the blood: Immunotherapy progresses from bacteria to bacterial DNA. Immunol Today 21:521-526
4. Rybchin VN, Svarchevsky AN (1999) The plasmid prophage N15: A linear DNA with covalently closed ends. Mol Microbiol 33:895-903
5. Deneke J, Ziegelin G, Lurz R, Lanka E (2000) The protelomerase of temperate Escherichia coli phage N15 has cleaving-joining activity. Proc Natl Acad Sci U S A 97:7721-7726
6. Nicolson GL, Dulski K, Basson C, Welch DR (1985) Preferential organ attachment and invasion in vitro by B16 melanoma cells selected for differing metastatic colonization and invasive properties. Invasion Metastasis 5:144-158
7. Hartikka J, Sawdey M, Cornefert-Jensen F, Margalith M, Barnhart K, Nolasco M, Vahlsing HL, Meek J, Marquet M, Hobart P, Norman J, Manthorpe M (1996) An improved plasmid DNA expression vector for direct injection into skeletal muscle. Hum Gene Ther 7:1205-1217
8. Schultz J, Pavlovic J, Strack B, Nawrath M, Moelling K (1999) Long-lasting anti-metastatic efficiency of interleukin 12-encoding plasmid DNA. Hum Gene Ther 10:407-417
9. Zimmermann S, Rommel C, Ziogas A, Lovric J, Moelling K, Radziwill G (1997) MEK1 mediates a positive feedback on Raf-1 activity independently of Ras and Src. Oncogene 15:1503-1511
10. Wexler H (1966) Accurate identification of experimental pulmonary metastases. J Natl Cancer Inst 36:641-645
11. Schultz J, Heinzerling L, Pavlovic J, Moelling K (2000) Induction of long-lasting cytokine effect by injection of IL-12 encoding plasmid DNA. Cancer Gene Ther 7:1557-1565
12. D'Andrea A, Rengaraju M, Valiante NM, Chehimi J, Kubin M, Aste M, Chan SH, Kobayashi M, Young D, Nickbarg E, Chizzonite R, Wolf SF, Trinchieri G (1992) Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J Exp Med 176:1387-1398
13. Kobayashi M, Fitz L, Ryan M, Hewick RM, Clark SC, Chan S, Loudon R, Sherman F, Perussia B, Trinchieri G (1989) Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med 170:827-845
14. Buttrick PM, Kass A, Kitsis RN, Kaplan ML, Leinwand LA (1992) Behavior of genes directly injected into the rat heart in vivo. Circ Res 70:193-198
15. Sykes KF, Johnston SA (1999) Linear expression elements: A rapid, in vivo, method to screen for gene function. Nat Biotech 17:355-359
16. Wittig B, Marten A, Dorbic T, Weineck S, Min H, Niemitz S, Trojaneck B, Flieger D, Kruopis S, Albers A, Loffel J, Neubauer A, Albers P, Muller S, Sauerbruch T, Bieber T, Huhn D, Schmidt-Wolf IG (2001) Therapeutic vaccination against metastatic carcinoma by expression-modulated and im-munomodified autologous tumor cells: A first clinical phase I/II trial. Hum Gene Ther 12:267-278
17. Darquet AM, Rangara R, Kreiss P, Schwartz B, Naimi S, Delaere P, Crouzet J, Scherman D (1999) Minicircle: An improved DNA molecule for in vitro and in vivo gene transfer. Gene Ther 6:209-218