Randomized, comparative, double-blind study of amlodipine vs. nicardipine as a treatment of isolated systolic hypertension in the elderly

Fundamental and Clinical Pharmacology

Volumn 16, Issue 6, 2002, Pages 537-544

  Mounier Véhier, Claire ^a   Jaboureck, Olivier ^a   Emeriau, Jean Paul ^b   Bernaud, Corine ^c   Clerson, Pierre ^d   Carre, Alain ^a  

^a LILLE UNIVERSITY HOSPITAL   (France)

^b Ctr Geriatrie Ctr Hosp Univ B   (France)

^c PFIZER INC   (United States)

^d Orgametrie   (France)

Author keywords

Amlodipine; Antihypertensive; Elderly patients; Isolated systolic hypertension; Nicardipine

Indexed keywords

AMLODIPINE; NICARDIPINE; ANTIHYPERTENSIVE AGENT;

ADULT; AGE; AGED; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE MONITORING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOSE CALCULATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG TOLERANCE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; PULSE PRESSURE; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC HYPERTENSION; TIME; TITRIMETRY; CIRCADIAN RHYTHM; COMPARATIVE STUDY; DRUG ADMINISTRATION; HYPERTENSION; PATHOPHYSIOLOGY; PATIENT COMPLIANCE;

AGED; AGED, 80 AND OVER; AMLODIPINE; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; BLOOD PRESSURE MONITORING, AMBULATORY; CIRCADIAN RHYTHM; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; HYPERTENSION; MALE; NICARDIPINE; PATIENT COMPLIANCE; TIME FACTORS;

EID: 0036454636     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1472-8206.2002.00129.x     Document Type: Article

References (33)

1. Franklin S.S., Gustin W. IV. Wong N.D., Larson M.G., Weber M.A., Kannel W.B., Levy D. Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study. Circulation (1997) 96 308-315.
2. Staessen J., Amery A., Fagard R. Isolated systolic hypertension in the elderly. J. Hypertens. (1990) 8 393-405.
3. Wang J.G., Staessen J.A. The benefit of treating isolated systolic hypertension. Curr. Hypertens. Rep. (2001) 3 333-339.
4. Wilking S.V., Belanger A., Kannel W.B., D'Agostino R.B., Steel K. Determinants of isolated systolic hypertension. JAMA (1988) 260 3451-3455.
5. Franklin S.S., Jacobs M.J., Wong N.D., L'Italien G.J., Lapuerta P. Predominance of isolated systolic hypertension among middle-aged and elderly US hypertensives: Analysis based on National Health and Nutrition Examination Survey (NHANES) III. Hypertension (2001) 37 869-874.
6. National High Blood Pressure Education Program Working Group Report on Hypertension in the Elderly. National High Blood Pressure Education Program Working Group. Hypertension. (1994) 23 275-285.
7. Gueyffier F., Froment A., Gouton M. New meta-analysis of treatment trials of hypertension: Improving the estimate of therapeutic benefit. J. Hum. Hypertens. (1996) 10 1-8.
8. SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA. (1991) 265 3255-3264.
9. Staessen J.A., Fagard R., Thijs L. et al. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Lancet (1997) 350 757-764.
10. Liu L., Wang J.G., Gong L., Liu G., Staessen J.A. Comparison of active treatment and placebo in older Chinese patients with isolated systolic hypertension. Systolic Hypertension in China (Syst-China) Collaborative Group. J. Hypertens. (1998) 16 1823-1829.
11. Staessen J.A., Gasowski J., Wang J.G., Thijs L. et al. Risks of untreated and treated isolated systolic hypertension in the elderly: Meta-analysis of outcome trials. Lancet (2000) 355 865-872.
12. Messerli F.H., Grossman E., Goldbourt U. Are beta-blockers efficacious as first-line therapy for hypertension in the elderly? A systematic review. JAMA (1998) 279 1903-1907.
13. Hansson L., Lindholm L.H., Ekbom T. et al. Randomised trial of old and new antihypertensive drugs in elderly patients: Cardiovascular mortality and morbidity the Swedish Trial in Old Patients with Hypertension-2 study. Lancet (1999) 354 1751-1756.
14. Zannad F. The potential advantages of a modern antihypertensive therapy in the elderly. J. Cardiovasc. Pharmacol. (2000) 35 19-23.
15. Zanchetti A. Role of calcium antagonists in systemic hypertension. Am. J. Cardiol. (1987) 59 130B-136B.
16. Herman Z.S. Application of calcium channel blockers in the treatment of cardiovascular diseases. Pol. J. Pharmacol. (1999) 51 201-206.
17. Abernethy D.R. The pharmacokinetic profile of amlodipine. Am. Heart J. (1989) 118 1100-1103.
18. van Zwieten P.A. Amlodipine: An overview of its pharmacody-namic and pharmacokinetic properties. Clin. Cardiol. (1994) 17 III3-III6.
19. Webster J., Fowler G., Jeffers T.A. et al. A comparison of amlodipine with enalapril in the treatment of isolated systolic hypertension. Br. J. Clin. Pharmacol. (1993) 35 499-505.
20. Murdoch D., Heel R.C. Amlodipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in cardiovascular disease. Drugs (1991) 41 478-505.
21. Osterloh I. The safety of amlodipine. Am. Heart J. (1989) 118 1114-1119.
22. Frampton J.E., Faulds D. Nicardipine. A review of its pharmacology and therapeutic efficacy in older patients. Drugs Aging (1993) 3 165-187.
23. O'Brien E., Mee F., Atkins N., O'Malley K. Accuracy of the SpaceLabs 90207 determined by the British Hypertension Society protocol. J. Hypertens. (1991) 9 573-574.
24. Staessen J.A., Thijs L., Fagard R. et al. Predicting cardiovascular risk using conventional vs ambulatory blood pressure in older patients with systolic hypertension. Systolic Hypertension in Europe Trial Investigators. JAMA (1999) 282 539-546.
25. Khattar R.S., Swales J.D., Dore C., Senior R., Lahiri A. Effect of aging on the prognostic significance of ambulatory systolic, diastolic, and pulse pressure in essential hypertension. Circulation (2001) 104 783-789.
26. Hansson L., Zanchetti A., Carruthers S.G. et al. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: Principal results of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study Group. Lancet (1998) 351 1755-1762.
27. Anon. The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. Arch. Intern. Med. (1997) 157 2413-2446.
28. Collins R., Peto R., MacMahon S. et al. Blood pressure, stroke, and coronary heart disease. Part 2, Short-term reductions in blood pressure: Overview of randomised drug trials in their epidemiological context. Lancet (1990) 335 827-838.
29. Nielsen W.B., Vestbo J., Jensen G.B. Isolated systolic hypertension as a major risk factor for stroke and myocardial infarction and an unexploited source of cardiovascular prevention: A prospective population-based study. J. Hum. Hypertens. (1995) 9 175-180.
30. Forette F., Seux M.L., Staessen J.A. et al. Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial. Lancet (1998) 352 1347-1351.
31. Galarza C.R., Alfie J., Waisman G.D. et al. Diastolic pressure underestimates age-related hemodynamic impairment. Hypertension (1997) 30 809-816.
32. Millar J.A., Lever A.F. Implications of pulse pressure as a predictor of cardiac risk in patients with hypertension. Hypertension (2000) 36 907-911.
33. Sever P.S. Simple blood pressure guidelines for primary health care. J. Hum. Hypertens. (1999) 13 725-727.