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Volumn 12, Issue 2, 2002, Pages 72-77

Evidence for a cellular and molecular decline in bone healing with age

Author keywords

Aging; Bone healing; Bone morphogenetic protein; Osteogenesis; Runx2

Indexed keywords

BONE MORPHOGENETIC PROTEIN;

EID: 0036450973     PISSN: 10486666     EISSN: None     Source Type: Journal    
DOI: 10.1053/otor.2002.36167     Document Type: Article
Times cited : (5)

References (44)
  • 3
    • 0028964614 scopus 로고
    • Bone progenitor cell deficits and the age-associated decline in bone repair capacity
    • Quarto R, Thomas D, Liang CT: Bone progenitor cell deficits and the age-associated decline in bone repair capacity. Calcif Tissue Int 56: 123-129, 1995
    • (1995) Calcif. Tissue Int. , vol.56 , pp. 123-129
    • Quarto, R.1    Thomas, D.2    Liang, C.T.3
  • 4
    • 0021847380 scopus 로고
    • Age-dependent decline in extracellular matrix-induced local bone differentiation
    • Reddi AH: Age-dependent decline in extracellular matrix-induced local bone differentiation. Isr J Med Sci 21:312-313, 1985
    • (1985) Isr. J. Med. Sci. , vol.21 , pp. 312-313
    • Reddi, A.H.1
  • 5
    • 0026488664 scopus 로고
    • Impaired bone activity in aged rats: Alterations at the cellular and molecular levels
    • Liang CT, Barnes J, Seedor JG, et al: Impaired bone activity in aged rats: alterations at the cellular and molecular levels. Bone 13:435-441, 1992
    • (1992) Bone , vol.13 , pp. 435-441
    • Liang, C.T.1    Barnes, J.2    Seedor, J.G.3
  • 6
    • 0028832292 scopus 로고
    • Effect of aging on the rat condylar fracture model evaluated by bromodeoxyuridine immunohistochemistry
    • Sekine J, Sano K, Inokuchi T: Effect of aging on the rat condylar fracture model evaluated by bromodeoxyuridine immunohistochemistry. J Oral Maxillofac Surg 53:1317-1323, 1995
    • (1995) J. Oral Maxillofac. Surg. , vol.53 , pp. 1317-1323
    • Sekine, J.1    Sano, K.2    Inokuchi, T.3
  • 7
    • 0035067737 scopus 로고    scopus 로고
    • The chondrogenic potential of periosteum decreases with age
    • O'Driscoll SW, Saris DB, Ito Y, et al: The chondrogenic potential of periosteum decreases with age. J Orthop Res 19:95-103, 2001
    • (2001) J. Orthop. Res. , vol.19 , pp. 95-103
    • O'Driscoll, S.W.1    Saris, D.B.2    Ito, Y.3
  • 8
    • 0017801350 scopus 로고
    • Electron microscopic study of bone surface changes during aging. The loss of cellular control and biofeedback
    • Tonna EA: Electron microscopic study of bone surface changes during aging. The loss of cellular control and biofeedback. J Gerontol 33:163-177, 1978
    • (1978) J. Gerontol. , vol.33 , pp. 163-177
    • Tonna, E.A.1
  • 9
    • 0033094213 scopus 로고    scopus 로고
    • Surgical treatment of acetabular fractures in elderly patients with osteoporotic bone
    • Mears DC: Surgical treatment of acetabular fractures in elderly patients with osteoporotic bone. J Am Acad Orthop Surg 7:128-141, 1999
    • (1999) J. Am. Acad. Orthop. Surg. , vol.7 , pp. 128-141
    • Mears, D.C.1
  • 10
    • 0033405496 scopus 로고    scopus 로고
    • Injury in the aging: Recovery and rehabilitation
    • Horan MA, Clague JE: Injury in the aging: Recovery and rehabilitation. Br Med Bull, 55:895-909, 1999
    • (1999) Br. Med. Bull. , vol.55 , pp. 895-909
    • Horan, M.A.1    Clague, J.E.2
  • 11
    • 0035158202 scopus 로고    scopus 로고
    • Treatment with 1,25-dihydroxyvitamin D3 reduces impairment of human osteoblast functions during cellular aging in culture
    • Kveiborg M, Rattan SI, Clark BF, et al: Treatment with 1,25-dihydroxyvitamin D3 reduces impairment of human osteoblast functions during cellular aging in culture. J Cell Physiol 186:298-306, 2001
    • (2001) J. Cell Physiol. , vol.186 , pp. 298-306
    • Kveiborg, M.1    Rattan, S.I.2    Clark, B.F.3
  • 12
    • 0034943091 scopus 로고    scopus 로고
    • Cortisol kinetics in elderly women with persistently high cortisol concentrations after proximal femur fracture
    • Barton RN, Horan MA, Rose JG, et al: Cortisol kinetics in elderly women with persistently high cortisol concentrations after proximal femur fracture. J Orthop Trauma 15:321-325, 2001
    • (2001) J. Orthop. Trauma , vol.15 , pp. 321-325
    • Barton, R.N.1    Horan, M.A.2    Rose, J.G.3
  • 13
    • 85047699915 scopus 로고    scopus 로고
    • Genetic enhancement of fracture repair: Healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene
    • Baltzer AW, Lattermann C, Whalen JD, et al: Genetic enhancement of fracture repair: Healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene. Gene Ther 7:734-739, 2000
    • (2000) Gene Ther. , vol.7 , pp. 734-739
    • Baltzer, A.W.1    Lattermann, C.2    Whalen, J.D.3
  • 14
    • 0032583430 scopus 로고    scopus 로고
    • Bone mass, bone fragility, and the decision to treat
    • Heaney RP: Bone mass, bone fragility, and the decision to treat. JAMA 280:2119-2120, 1998
    • (1998) JAMA , vol.280 , pp. 2119-2120
    • Heaney, R.P.1
  • 15
    • 0011943388 scopus 로고
    • Group WHOOS: Osteoporosis Consensus Development Conference. World Health Organization
    • Group WHOOS: Osteoporosis Consensus Development Conference. World Health Organization, 21, 1991.
    • (1991) , vol.21
  • 16
    • 0028256243 scopus 로고
    • Aging of human trabecular osteoblasts in culture
    • Ankersen L: Aging of human trabecular osteoblasts in culture. Arch Gerontol Geriatr 4:5-12, 1994 (suppl)
    • (1994) Arch. Gerontol. Geriatr. , vol.4 , Issue.SUPPL. , pp. 5-12
    • Ankersen, L.1
  • 17
    • 0031441654 scopus 로고    scopus 로고
    • Demonstration of cellular aging and senescence in serially passaged long-term cultures of human trabecular osteoblasts
    • Kassem M, Ankersen L, Eriksen EF, et al: Demonstration of cellular aging and senescence in serially passaged long-term cultures of human trabecular osteoblasts. Osteoporos Int 7:514-524, 1997
    • (1997) Osteoporos Int. , vol.7 , pp. 514-524
    • Kassem, M.1    Ankersen, L.2    Eriksen, E.F.3
  • 18
    • 0034015067 scopus 로고    scopus 로고
    • CBFA1 and topoisomerase I mRNA levels decline during cellular aging of human trabecular osteoblasts
    • Christiansen M, Kveiborg M, Kassem M, et al: CBFA1 and topoisomerase I mRNA levels decline during cellular aging of human trabecular osteoblasts. J Gerontol A Biol Sci Med Sci 55B;194-200, 2000
    • (2000) J. Gerontol. A Biol. Sci. Med. Sci. , vol.55 B , pp. 194-200
    • Christiansen, M.1    Kveiborg, M.2    Kassem, M.3
  • 19
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
    • Ducy P, Zhang R, Geoffroy V, et al: Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation. Cell 89:747-754, 1997
    • (1997) Cell , vol.89 , pp. 747-754
    • Ducy, P.1    Zhang, R.2    Geoffroy, V.3
  • 20
    • 0025072520 scopus 로고
    • Influence of experimental conditions on osteoblast activity in human primary bone cell cultures
    • Chavassieux PM, Chenu C, Valentin-Opran A, et al: Influence of experimental conditions on osteoblast activity in human primary bone cell cultures. J Bone Miner Res 5:337-343, 1990
    • (1990) J. Bone Miner. Res. , vol.5 , pp. 337-343
    • Chavassieux, P.M.1    Chenu, C.2    Valentin-Opran, A.3
  • 21
    • 0026588602 scopus 로고
    • Age-related changes in hyaluronan, proteoglycan, collagen, and osteonectin synthesis by human bone cells
    • Fedarko NS, Vetter UK, Weinstein S, et al: Age-related changes in hyaluronan, proteoglycan, collagen, and osteonectin synthesis by human bone cells. J Cell Physiol 151:215-227, 1992
    • (1992) J. Cell Physiol. , vol.151 , pp. 215-227
    • Fedarko, N.S.1    Vetter, U.K.2    Weinstein, S.3
  • 22
    • 0029081142 scopus 로고
    • Age-dependent expression of osteoblastic phenotypic markers in normal human osteoblasts cultured long-term in the presence of dexamethasone
    • Sutherland MS, Rao LG, Muzaffar SA, et al: Age-dependent expression of osteoblastic phenotypic markers in normal human osteoblasts cultured long-term in the presence of dexamethasone. Osteoporos Int 5:335-343, 1995
    • (1995) Osteoporos Int. , vol.5 , pp. 335-343
    • Sutherland, M.S.1    Rao, L.G.2    Muzaffar, S.A.3
  • 23
    • 0027207351 scopus 로고
    • Mitogenic responsiveness of human bone cells in vitro to hormones and growth factors decreases with age
    • Pfeilschifter J, Diel I, Pilz U, et al: Mitogenic responsiveness of human bone cells in vitro to hormones and growth factors decreases with age. J Bone Miner Res 8:707-717, 1993
    • (1993) J. Bone Miner. Res. , vol.8 , pp. 707-717
    • Pfeilschifter, J.1    Diel, I.2    Pilz, U.3
  • 24
    • 18744427354 scopus 로고    scopus 로고
    • Influence of skeletal site of origin and donor age on osteoblastic cell growth and differentiation
    • Martinez ME, del Campo MT, Medina S, et al: Influence of skeletal site of origin and donor age on osteoblastic cell growth and differentiation. Calcif Tissue Int 64:280-286, 1999
    • (1999) Calcif. Tissue Int. , vol.64 , pp. 280-286
    • Martinez, M.E.1    del Campo, M.T.2    Medina, S.3
  • 25
    • 0028917513 scopus 로고
    • Human endosteal osteoblastic cells: Relationship with bone formation
    • Marie PJ: Human endosteal osteoblastic cells: Relationship with bone formation. Calcif Tissue Int 56:S13-S16, 1995 (suppl 1)
    • (1995) Calcif. Tissue Int. , vol.56 , Issue.SUPPL. 1
    • Marie, P.J.1
  • 26
    • 0011952191 scopus 로고    scopus 로고
    • Age related changes in the response of callus forming cells to mechanical stimuli may be responsible for faster healing of young rat tibial fractures
    • Shroff M, Levy M, Joyner C, et al: Age related changes in the response of callus forming cells to mechanical stimuli may be responsible for faster healing of young rat tibial fractures. J Bone Joint Surg 82B:132-133, 2000 (suppl 2)
    • (2000) J. Bone Joint Surg. , vol.82 B , Issue.SUPPL. 2 , pp. 132-133
    • Shroff, M.1    Levy, M.2    Joyner, C.3
  • 27
  • 28
    • 0022406118 scopus 로고
    • The effect of aging on bone formation in rats: Biochemical and histological evidence for decreased bone formation capacity
    • Nishimoto SK, Chang CH, Gendler E, et al: The effect of aging on bone formation in rats: Biochemical and histological evidence for decreased bone formation capacity. Calcif Tissue Int 37:617-624, 1985
    • (1985) Calcif. Tissue Int. , vol.37 , pp. 617-624
    • Nishimoto, S.K.1    Chang, C.H.2    Gendler, E.3
  • 29
    • 0021780093 scopus 로고
    • Osteoporosis: A bone morphogenetic protein auto-immune disorder
    • Urist MR, Hudak RT, Huo YK, et al: Osteoporosis: A bone morphogenetic protein auto-immune disorder. Prog Clin Biol Res 187:77-96, 1985
    • (1985) Prog. Clin. Biol. Res. , vol.187 , pp. 77-96
    • Urist, M.R.1    Hudak, R.T.2    Huo, Y.K.3
  • 30
    • 0027583414 scopus 로고
    • Factors for osseous repair and delivery
    • Hollinger J: Factors for osseous repair and delivery. Part I. J Craniofac Surg 4:102-108, 1993
    • (1993) J. Craniofac. Surg. , vol.4 , Issue.PART I , pp. 102-108
    • Hollinger, J.1
  • 31
    • 0018888080 scopus 로고
    • Mineralization and metabolic response in serially passaged adult rat bone cells
    • Williams DC, Boder GB, Toomey RE, et al: Mineralization and metabolic response in serially passaged adult rat bone cells. Calcif Tissue Int 30:233-246, 1980
    • (1980) Calcif. Tissue Int. , vol.30 , pp. 233-246
    • Williams, D.C.1    Boder, G.B.2    Toomey, R.E.3
  • 32
    • 0033105037 scopus 로고    scopus 로고
    • Influence of skeletal site of origin and donor age on 1,25(OH)2D3-induced response of various osteoblastic markers in human osteoblastic cells
    • Martinez ME, Medina S, Sanchez M, et al: Influence of skeletal site of origin and donor age on 1,25(OH)2D3-induced response of various osteoblastic markers in human osteoblastic cells. Bone 24:203-209, 1999
    • (1999) Bone , vol.24 , pp. 203-209
    • Martinez, M.E.1    Medina, S.2    Sanchez, M.3
  • 33
    • 0028343615 scopus 로고
    • Evidence for a diminished maturation of preosteoblasts into osteoblasts during aging in rats: An ultrastructural analysis
    • Roholl PJ, Blauw E, Zurcher C, et al: Evidence for a diminished maturation of preosteoblasts into osteoblasts during aging in rats: An ultrastructural analysis. J Bone Miner Res 9:355-366, 1994
    • (1994) J. Bone Miner. Res. , vol.9 , pp. 355-366
    • Roholl, P.J.1    Blauw, E.2    Zurcher, C.3
  • 36
    • 0022357164 scopus 로고
    • Human bone matrix gelatin as a clinical alloimplant. A retrospective review of 160 cases
    • Kakiuchi M, Hosoya, T, Takaoka K, et al: Human bone matrix gelatin as a clinical alloimplant. A retrospective review of 160 cases. Int Orthop 9:181-188, 1985
    • (1985) Int. Orthop. , vol.9 , pp. 181-188
    • Kakiuchi, M.1    Hosoya, T.2    Takaoka, K.3
  • 37
    • 0035375351 scopus 로고    scopus 로고
    • Effect of aging on bone formation induced by recombinant human bone morphogenetic protein-2 combined with fibrous collagen membranes at subperiosteal sites
    • Matsumoto A, Yamaji K, Kawanami M, et al: Effect of aging on bone formation induced by recombinant human bone morphogenetic protein-2 combined with fibrous collagen membranes at subperiosteal sites. J Periodont Res 36:175-182, 2001
    • (2001) J. Periodont. Res. , vol.36 , pp. 175-182
    • Matsumoto, A.1    Yamaji, K.2    Kawanami, M.3
  • 38
    • 0022374401 scopus 로고
    • Immunologic evidence of a bone morphogenetic protein in the milieu interieur
    • Urist MR, Nillsson OS, Hudak R, et al: Immunologic evidence of a bone morphogenetic protein in the milieu interieur. Ann Biol Clin 43:755-766, 1985
    • (1985) Ann. Biol. Clin. , vol.43 , pp. 755-766
    • Urist, M.R.1    Nillsson, O.S.2    Hudak, R.3
  • 39
    • 0029852463 scopus 로고    scopus 로고
    • The effects of aging on the bone inductive activity of recombinant human bone morphogenetic protein-2
    • Fleet JC, Cashman K, Cox K, et al: The effects of aging on the bone inductive activity of recombinant human bone morphogenetic protein-2. Endocrinology 137:4605-4610, 1996
    • (1996) Endocrinology , vol.137 , pp. 4605-4610
    • Fleet, J.C.1    Cashman, K.2    Cox, K.3
  • 40
    • 0023775220 scopus 로고
    • Skeletal repair in the aged: A preliminary study in rabbits
    • Strates BS, Stock AJ, Connolly JF: Skeletal repair in the aged: a preliminary study in rabbits. Am J Med Sci 296:266-269, 1988
    • (1988) Am. J. Med. Sci. , vol.296 , pp. 266-269
    • Strates, B.S.1    Stock, A.J.2    Connolly, J.F.3
  • 41
    • 0012013196 scopus 로고
    • Properties of osteoprogenitor cells in bone marrow of aged and ovarectomized rats
    • Nishida S: Properties of osteoprogenitor cells in bone marrow of aged and ovarectomized rats. J Bone Miner Res 7:113, 1992 (suppl 1)
    • (1992) J. Bone Miner. Res. , vol.7 , Issue.SUPPL. 1 , pp. 113
    • Nishida, S.1
  • 42
    • 0036361986 scopus 로고    scopus 로고
    • Peripheral artery disease, diabetes, and reduced lower extremity functioning
    • Dolan NC, Liu K, Criqui MH, et al: Peripheral artery disease, diabetes, and reduced lower extremity functioning. Diabet Care 25:113-120, 2002
    • (2002) Diabet Care , vol.25 , pp. 113-120
    • Dolan, N.C.1    Liu, K.2    Criqui, M.H.3
  • 43
    • 0032905584 scopus 로고    scopus 로고
    • Reconstruction for lower limb occlusive disease in the elderly
    • Smith JJ, Toogood GJ, Galland RB: Reconstruction for lower limb occlusive disease in the elderly. Cardiovasc Surg 7:58-61, 1999
    • (1999) Cardiovasc. Surg. , vol.7 , pp. 58-61
    • Smith, J.J.1    Toogood, G.J.2    Galland, R.B.3
  • 44
    • 0036192007 scopus 로고    scopus 로고
    • Decreases in bone blood flow and bone material properties in aging Fischer-344 rats
    • Bloomfield SA, Hogan HA, Delp MD: Decreases in bone blood flow and bone material properties in aging Fischer-344 rats. Clin Orthop 396:248-257, 2002
    • (2002) Clin. Orthop. , vol.396 , pp. 248-257
    • Bloomfield, S.A.1    Hogan, H.A.2    Delp, M.D.3


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