Binding free energy differences in a TCR-peptide-MHC complex induced by a peptide mutation: A simulation analysis

Journal of Molecular Biology

Volumn 324, Issue 3, 2002, Pages 547-569

  Michielin, Olivier ^a,b,c,d   Karplus, Martin ^b,e  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Switzerland)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^d LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^e HARVARD UNIVERSITY   (United States)

Author keywords

Immune response; Immunogenic peptides; Molecular dynamics; Proteins; Solvation effects

Indexed keywords

HLA A2 ANTIGEN; MUTANT PROTEIN; T LYMPHOCYTE RECEPTOR;

ANTIGEN PRESENTATION; ARTICLE; DECOMPOSITION; ENERGY; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; MOLECULE; MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; RECEPTOR AFFINITY; RECEPTOR BINDING; SIMULATION; WILD TYPE;

EID: 0036447407     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)00880-X     Document Type: Article

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