Growth factor stimulated cell proliferation is accompanied by an elevated labile intracellular pool of zinc in 3T3 cells

Canadian Journal of Physiology and Pharmacology

Volumn 80, Issue 8, 2002, Pages 790-795

  Paski, Shirley C ^a   Xu, Zhaoming ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

3T3 cells; Cell proliferation; DNA synthesis; EGF; IGF I; Labile intracellular pool of zinc; PDGF

Indexed keywords

DNA; EPIDERMAL GROWTH FACTOR; GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR; SOMATOMEDIN; THYMIDINE; TRITIUM; ZINC;

ANIMAL CELL; ARTICLE; CELL COUNT; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STIMULATION; CELL STRAIN 3T3; CONTROLLED STUDY; CULTURE MEDIUM; DNA SYNTHESIS; DRUG EFFECT; FLUORESCENCE MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STIMULUS RESPONSE;

3T3 CELLS; ANIMALS; CELL DIVISION; DNA; GROWTH SUBSTANCES; INTRACELLULAR FLUID; MICE; ZINC;

EID: 0036446451     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y02-101     Document Type: Article

References (26)

1. Andrews, J.C., Nolan, J.P., Hammerstedt, R.H., and Bavister, B.D.. 1995. Characterization of N-(6-methoxy-8-quinolyl)-p-toluenesulfonamide for the detection of zinc in living sperm cells. Cytometre 21: 153-159.
2. val-12 expressing NIH 3T3 cells. Exp. Cell Res. 208: 303-310.
3. Binz, K., Zapf, J., and Froesch, E.R. 1989. The role of insulin-like growth factor I in growth of diabetic rats. Acta Endocrinol. 121: 628-632.
4. Blakesley, V., Kalebic, T., Helman, L., Stannard, B., Faria, T., Roberts, C., and LeRoith, D. 1996. Tumorigenic and mitogenic capacities are reduced in transfected fibroblasts expressing mutant insulin-like growth factor (IGF)-I receptors. The role of tyrosine residues 1250, 1251, and 1316 in the carboxy-terminus of the IGF-I receptor. Endocrinology. 137: 410-417.
5. Browing, J.D., MacDonald, R.S., Thornton, W.H., and O'Dell, B.L. 1998. Reduced food intake in zinc deficient rats is normalized by megestrol acetate but not by insulin-like growth factor-I. J. Nutr. 128: 136-142.
6. Budde, T., Minta, A., White, J., and Kay, A. 1997. Imaging free zinc in synaptic terminals in live hippocampal slices. Neuroscience. 79: 347-358.
7. Campisi, J., and Pardee, A.B. 1984. Post-transcriptional control of the onset of DNA synthesis by an insulin-like growth factor. Mol. Cell. Biol. 4: 1807-1814.
8. 2+ requirement for DNA synthesis by 3T3 cells. Exp. Cell Res. 192: 631-634.
9. 2+ requirement for DNA synthesis by 3T3 cells. Exp. Cell Res. 184: 499-508.
10. Chesters, J.K., Petrie, L., and Lipson, K.E. 1993. Two zinc-dependent steps during G1 to S phase transition. J. Cell. Physiol. 155: 445-451.
11. Clegg, M.S., Keen, C.L., and Donovan, S.M. 1995. Zinc deficiency-induced anorexia influences the distribution of serum insulin-like growth factor-binding proteins in the rat. Metabolism. 44: 1495-1501.
12. Frederickson, C., Kasarskis, E., Ringo, D., and Frederickson, R. 1987. A quinoline fluorescence method for visualizing and assaying histochemically reactive zinc (bouton zinc) in the brain. J. Neurosci. Methods. 20: 91-103.
13. Garin, E.H., Grant, M.B., and Silverstein, J.H. 1989. Insulinlike growth factors in patients with active nephrotic syndrome. Am. J. Diseases Children, 143: 865-867.
14. Koike, T., Watanabe, T., Aoki, S., Kimura, E., and Shiro, M. 1996. A novel biomimetic zinc)II)-fluorophore, dansylamidoehtyl-pendant macrocyclic tetraamine 1,4,7,10-tetraazacyclodo-decane (Cyclen). J. Am. Chem. Soc. 118: 12 678 - 12 703.
15. 1 in PDGF stimulated density-arrested Balb/c-3T3 cells. Exp. Cell Res. 147: 202-208.
16. Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J. 1951. Protein measurement with the Folin phenol reagent. Anal. Biochem. 193: 265-275.
17. MacDonald, R.S., Wollard-Biddle, L.C., Browning, J.D., Thornton, W.H. Jr., and O'Dell, B.L. 1998. Zinc deprivation of murine 3T3 cells by use of diethylenetrinitrilopentaacetate impairs DNA synthesis upon stimulation with insulin-like growth factor-I (IGF-I). J. Nutr. 128: 1600-1605.
18. Paski, S., and Xu, Z. 2001. Labile intracellular zinc is associated with 3T3 cell growth. J. Nutr. Biochem. 12: 655-661.
19. Pledger, W.J., Stiles, C.D., Antoniades, H.N., and Scher, C.D. 1977. Induction of DNA synthesis in Balb/c-3T3 cells by serum components: Reevaluation of the commitment precess. Proc. Natl. Acad. Sci. U.S.A. 74: 4481-4485.
20. Prasad, A.S., Beck, F.W., Endre, L., Handschu, W., Kukuruga, M., and Kumar, G. 1996. Zinc deficiency affects cell cycle and deoxythymidine kinase gene expression in HUT-78 cells. J. Lab. Clin. Med. 128: 51-60.
21. Reyes, J., Santander, M., Martinez, P., Arce, R., and Benos, D. 1994. A fluorescence method to determine picomole amounts of Zn(II) in biological systems. Biol. Res. 27: 49-56.
22. Roth, H.P., and Kirchgessner, M. 1994. Influence of alimentary zinc deficiency on the concentration of growth hormone (GH), insulin-like growth factor I (IGF-I) and insulin in the serum of force-fed rats. Horm. Metab. Res. 26: 404-408.
23. Scher, C.D., Shepard, R.C., Antoniades, H.N., and Stiles, C.D. 1979. Platelet-derived growth factor and the regulation of the mammalian fibroblast cell cycle. Biochem. Biophys. Acta, 560: 217-241.
24. Snyder, D.K., Clemmons, D.R., and Underwood, L.E. 1989. Dietary carbohydrate content determines responsiveness to growth hormone in energy-restricted humans. J. Clin. Endo. Metab. 69: 745-752.
25. Thornton, W., MacDonald, R., Wollard-Biddle, L., Browning, J., and O'Dell, B. 1998. Chelation of extracellular zinc inhibits proliferation in 3T3 cells independent of insulin-like growth factor-1 receptor expression. Proc. Soc. Exp. Biol. Med. 219: 64-68.
26. Zalewski, P., Forbes, I., and Betts, W. 1993. Correlation of apoptosis with change in intracellular labile Zn(II) using Zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II). Biochem. J. 296: 403-408.