Implication of distinct proteins in cadmium uptake and transport by intestinal cells HT-29

Cell Biology and Toxicology

Volumn 18, Issue 6, 2002, Pages 409-423

  Lecoeur, S ^a   Huynh Delerme, C ^a   Blais, A ^b   Duche A ^a   Tome D ^b   Kolf Clauw, M ^a  

^a ECOLE NATIONALE VÉTÉRINAIRE D ALFORT   (France)

^b AGROPARISTECH   (France)

Author keywords

Cadmium uptake; HT29 cells; Metallothionein; Nramp2

Indexed keywords

2,4 DINITROPHENOL; CADMIUM; CHLOROMERCURIBENZENESULFONIC ACID; COMPLEMENTARY DNA; COPPER; METALLOTHIONEIN; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; OUABAIN; PROTEIN; VERAPAMIL; ZINC; CADMIUM CHLORIDE; CATION TRANSPORT PROTEIN; IRON BINDING PROTEIN; LACTATE DEHYDROGENASE; MEMBRANE PROTEIN; MESSENGER RNA; SOLUTE CARRIER FAMILY 11 (PROTON COUPLED DIVALENT METAL ION TRANSPORTERS), MEMBER 2; SOLUTE CARRIER FAMILY 11- (PROTON-COUPLED DIVALENT METAL ION TRANSPORTERS), MEMBER 2;

ACTIVE TRANSPORT; ARTICLE; CELL GROWTH; CONTROLLED STUDY; DIFFUSION; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; MEMBRANE BINDING; PRIORITY JOURNAL; PROTON TRANSPORT; BIOSYNTHESIS; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CELL STRAIN HT29; COLON; DUODENUM; ENZYMOLOGY; EPITHELIUM CELL; METABOLISM; PATHOLOGY; PH; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSPORT AT THE CELLULAR LEVEL;

STROPHANTHUS GRATUS;

BIOLOGICAL TRANSPORT; CADMIUM CHLORIDE; CATION TRANSPORT PROTEINS; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; COLON; DNA, COMPLEMENTARY; DUODENUM; EPITHELIAL CELLS; HT29 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; IRON-BINDING PROTEINS; L-LACTATE DEHYDROGENASE; MEMBRANE PROTEINS; METALLOTHIONEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0036439192     PISSN: 07422091     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020867707079     Document Type: Article

References (54)

1. Andersen O, Nielsen JB, Sorensen JA, Scherrebeck L. Experimental localization of intestinal uptake sites for metals (Cd, Hg, Zn, Se) in vivo in mice. Environ Health Perspect. 1994;102:199-206.
2. Bhattacharyya MH, Wilson AK, Silbergeld EK, Watson L, Jeffery E. Metal-induced osteotoxicities. In: Goyer RA, Klaassen CD, Waalkes MP, eds. Metal Toxicology. San Diego: Academic Press; 1995:465-510.
3. Blais A, Aymard P, Lacour B. Paracellular calcium transport across Caco-2 and HT29 cell monolayers. Eur J Physiol. 1997;434:300-5.
4. Blais A, Lecoeur S, Milhaud G, Tomé D, Kolf-Clauw M. Cadmium uptake and transepithelial transport in control and long-term exposed Caco-2 cells: The role of metallothionein. Toxicol Appl Pharmacol. 1999;160:76-85.
5. Bobilya DJ, Briske Anderson M, Reeves PG. Zinc transport into endothelial cells is a facilitated process. J Cell Physiol. 1992;151:1-7.
6. Danielson KG, Ohi S, Huang PC. Immunochemical detection of metallothionein in specific epithelial cells or rat organs. Proc Natl Acad Sci USA. 1982;79:2301-4.
7. Dressman JB, Berardi RR, Dermentzoglou LC, et al. Upper gastrointestinal pH in young, healthy men and women. Pharm Res. 1990;7:756-61.
8. Duizer E, Gilde AJ, Versantvoort CHM, Groten JP. Effects of cadmium chloride on the paracellular barrier function of intestinal cell lines. Toxicol Appl Pharmacol. 1999;155:117-26.
9. Elisma F, Jumarie C. Evidence for cadmium uptake through Nramp2: Metal speciation studies with Caco-2 cells. Biochem Biophys Res Commun. 2001;285:662-8.
10. Elsenhans B, Kolb K, Schymann K, Forth W. The longitudinal distribution of cadmium, zinc, copper, iron, and metallothionein in the small-intestinal mucosa of rats after administration of cadmium chloride. Biol Trace Elem Res. 1994;41:31-46.
11. Elsenhans B, Strugala GJ, Schäfer SG. Small-intestinal absorption of cadmium and the significance of mucosal metallothionein. Hum Exp Toxicol. 1997;16:429-34.
12. Endo T, Kimura O, Sakata M. Effects of zinc and copper on uptake of cadmium by LLC-PK1 cells. Biol Pharm Bull. 1996;19:944-8.
13. Endo T. Transport of cadmium across the apical membrane of epithelial cell lines. Comp Biochem Physiol C Toxicol Pharmacol. 2002;131:223-9.
14. Evans DF. Pye G, Bramley R, Clark AG, Dyson TJ, Hardcastle JD. Measurements of gastrointestinal pH profiles in normal ambulant human subjects. Gut. 1988;29:1035-41.
15. Fogh J, Fogh JM, Orfeo T. One hundred and twenty seven cultured human tumor cell lines producing tumors in nude mice. J Natl Canc Inst. 1977;59:221-6.
16. Foulkes EC. On the mechanism of transfer of heavy metals across cell membranes. Toxicology. 1988;52:263-72.
17. Foulkes EC. Further findings on the mechanism of cadmium uptake by intestinal mucosal cells (step 1 of Cd absorption). Toxicology. 1991;70:261-70.
18. Foulkes EC, Bergman D. Inorganic mercury absorption in mature and immature rat jejunum: Transcellular and intercellular pathways in vivo and everted sacs. Toxicol Appl Pharmacol. 1993;120:89-95.
19. Foulkes EC, MacMullen DM. Kinetics of trans-epithelial movement of heavy metals in rat jejunum. Am J Physiol. 1987:253:134-8.
20. Friberg L, Kjellström T, Nordberg GF. Cadmium. In: Friberg L, Nordberg GF, Vouk VB, eds. Handbook on the Toxicology of Metals. Amsterdam: Elsevier; 1986;11:130-75.
21. Goering PL, Waalkes MP, Klaassen CD. Toxicology of cadmium. In: Goyer RA, Cherian MG. eds. Toxicology of Metals: Biochemical Aspects. Handbook of Experimental Pharmacology. New York: Springer-Verlag; 1995:115:189-213.
22. Goon D, Klaassen CD, Dosage-dependent absorption of cadmium in the rat intestine measured in situ. Toxicol Appl Pharmacol. 1989;100:41-50.
23. Gunshin H, Mackenzie B, Berger UV, et al. Cloning and characterization of a mammalian proton-coupled metalion transporter. Nature. 1997;388:482-8.
24. Han O, Fleet JC, Wood RJ. Reciprocal regulation of HFE and Nramp2 gene expression by iron in human intestinal cells. J Nutr. 1999;129:98-104.
25. Jarup L, Berglund M, Elinder CG, Nordberg G, Vahter M. Health effects of cadmium exposure: A review of literature and a risk estimate. Scand J Work Environ Health. 1998; 24:1-51.
26. Jin N, Kimura M, Yokoi K, Itokawa Y. A gel filtration high-performance liquid chromatographic method for determination of hepatic and renal metallothionein of rat and in comparison with the cadmium-saturation method. Biol Trace Elem Res. 1993;36:183-90.
27. Jumarie C, Campbell PGC, Berteloot A, Houde M, Denizeau F. Caco-2 cell line used as an in vitro model to study cadmium accumulation in intestinal epithelial cells. J Membr Biol. 1997;158:31-48.
28. Jumarie C, Campbell PGC, Houde M, Denizeau F. Evidence for an intracellular barrier to cadmium transport through Caco-2 cell monolayers. J Cell Physiol. 1999;180:285-97.
29. Klaassen CD, Liu J. Role of metallothionein in cadmium-induced hepatotoxicity and nephrotoxicity. Drug Metab Rev. 1997;29:79-102.
30. Klaassen CD, Liu J, Choudhuri S. Metallothionein: An intracellular protein to protect against cadmium toxicity. Annu Rev Pharmacol Toxicol. 1999;39:267-94.
31. Lind Y, Wicklund Glynn A. The involvement of metallothionein in the intestinal absorption of cadmium in mice. Toxicol Lett. 1997;91:179-87.
32. Min KS, Fujita Y, Onosaka S, Tanaka K. Role of intestinal metallothionein in absorption and distribution of orally administered cadmium. Toxicol Appl Pharmacol. 1991;109: 7-16.
33. Min KS, Nakatsubo T, Kawamura S, Fujita Y. Onosaka S, Tanaka K. Effects of mucosal metallothionein in small intestine on tissue distribution of cadmium after oral administration of cadmium compounds. Toxicol Appl Pharmacol. 1992;113:306-10.
34. Mitchell DB, Santone KS,Acosta D. Evaluation of cytotoxicity in cultured cells by enzyme leakage. J Tissue Cult Methods. 1980;6:113-17.
35. Morselt AF. Environmental pollutants and diseases. A cell biological approach using chronic cadmium exposure in the animal model as a paradigm case. Toxicology. 1991;70: 1-132.
36. 1 cells. Toxicol Appl Pharmacol. 1997;142:1-12.
37. Ohta H, Cherian MG. Gastrointestinal absorption of cadmium and metallothionein. Toxicol Appl Pharmacol. 1991;107: 63-72.
38. Phillpotts CJ. The autoradiographic localisation of retained orally administrated tracer within Paneth cells of rat duodenum. Toxicology. 1984;33:59-66.
39. Pigman EA, Blanchard J, Laird HE. A study of cadmium transport pathways using the Caco-2 cell model. Toxicol Appl Pharmacol. 1997;142:243-7.
40. Pinot F, Kreps SE, Bachelet M, Hainaut P, Bakonyi M, Polla BS. Cadmium in the environnement: Sources, mechanisms of biotoxicity, and biomarkers. Rev Environ Health. 2000; 15:299-323.
41. Rindley MJ, Traber MG. A specific sorting signal is not required for the polarized secretion of newly synthesized proteins from cultured intestinal cells. J Cell Biol. 1988; 107:471-9.
42. Satarug S, Haswell-Elkins MR, Moore MR. Safe levels of cadmium intake to prevent renal toxicity in human subjects. Br J Nutr. 2000;84:791-802.
43. Saito S, Kojima Y. Differential role of metallothionein on Zn, Cd and Cu accumulation in hepatic cytosol of rats. Cell Mol Life Sci. 1997;53:267-70.
44. Scarino ML, Poverini R, Di Lullo G, Bises G. Metallothionein gene expression in the intestinal cell: Modulation of mRNA and protein synthesis by copper and zinc. Biochem Soc Trans. 1991;19:283s-91s.
45. - cotransporter activity in HT-29 human adenocarcinoma cells. J Am Physiol Soc. 1993;82:857-65.
46. Sorensen JA, Nielsen JB, Andersen O. Identification of the gastrointestinal absorption site for cadmium chloride in vivo. Pharmacol Toxicol. 1993;73:169-73.
47. Tandy S, Williams M, Leggett A, et al. Nramp2 expression is associated with pH-dependent iron uptake across the apical membrane of human intestinal Caco-2 cells. J Biol Chem. 2000;275:1023-9.
48. Thévenod F, Friedmann JM, Katsen AD, Hauser IA. Upregulation of multidrug resistance P-glycoprotein via nuclear factor-κB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis. J Biol Chem. 2000;275:1887-96.
49. - cotransport in HT-29 cells. J Biol Chem. 1989; 264:6667-74.
50. Velcich A, Palumbo L, Jarry A, Laboisse C, Racevskis J, Augenlicht L. Patterns of expression of lineage-specific markers during the in vitro-induced differentiation of HT29 colon carcinoma cells. Cell Growth Differ. 1995;6:749-57.
51. Viallard V, Denis C, Trocheris V, Murat JC. Effect of glutamine deprivation and glutamate or ammonium chloride addition on growth rate, metabolism and differentiation of human colon cancer cell-line HT29. Int J Biochem. 1986;18:263-9.
52. Waalkes MP, Misra RR. Cadmium carcinogenicity and genotoxicity. In: Chang L, ed. Toxicology of Metals. Boca Raton, FL: CRC Press; 1996:231-44.
53. Webb M. The chemistry, biochemistry and biology of cadmium: Amsterdam: Elsevier; 1979.
54. Zoller H, Pietrangelo A, Vogel W, Weiss G. Duodenal metaltransporter (DMT-1, NRAMP-2) expression in patients with hereditary haemochromatosis. Lancet. 1999;353: 2120-3.