The stimulatory effect of clonidine on locus coeruleus neurons of rats with activated α2-adrenoceptors: Involvement of imidazoline receptors located in the nucleus paragigantocellularis

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 355, Issue 2, 1997, Pages 288-294

  Ruiz Ortega, J Angel ^a   Ugedo, Luisa ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

Clonidine; Electrolytic lesion; Imidazoline receptor; Locus coeruleus neurons; Nucleus paragigantocellularis; Single cell recording

Indexed keywords

2 ETHOXY 1(2H) QUINOLINECARBOXYLIC ACID ETHYL ESTER; ALPHA 2 ADRENERGIC RECEPTOR; CLONIDINE; IMIDAZOLINE RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; BRAIN INJURY; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GIANT CELL; HISTOLOGY; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LOCUS CERULEUS; MALE; NERVE CONDUCTION; NONHUMAN; RAT; REGIONAL PERFUSION;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; BLOOD PRESSURE; CLONIDINE; ELECTROPHYSIOLOGY; LOCUS COERULEUS; MALE; MEDULLA OBLONGATA; MICROINJECTIONS; NEURONS; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, DRUG;

EID: 0031030015     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00004945     Document Type: Article

References (56)

1. Akaoka H, Saunier C-F, Chergui K, Charléty P, Buda M, Chouvet G (1992) Combining in vivo volume-controlled pressure microejection with extracellular unit recording. J Neurosci Methods 42:119-128
2. Atlas D, Burstein Y (1984) Isolation and partial purification of clonidine-displacing endogenous brain substance. Eur J Biochem 144:287-293
3. Aston-Jones G, Ennis M, Pieribone VA, Nickell WT, Shipley MT (1986) The brain nucleus locus coeruleus: restricted afferent control of a broad efferent network. Science 234:734-737
4. Aston-Jones G, Foote SL, Bloom FE (1982) Low doses of ethanol disrupt sensory responses of brain noradrenergic neurons. Nature 296:857-860
5. Bousquet P (1995) Imidazoline receptors: from basic concepts to recent developments. J Cardiovasc Pharmacol 26:S1-S6
6. Bousquet P, Feldman J, Schwartz J (1984) Central cardiovascular effects of alpha adrenergic drugs difference between catecholamines and imidazolines. J Pharmacol Exp Ther 230:232-236
7. Bricca G, Dontenwill M, Molines A, Feldman J, Belcourt A, Bousquet P (1989) The imidazoline preferring receptor: binding studies in bovine, rat and human brainstem. Eur J Pharmacol 162:1-9
8. 2-Adrenoceptor subtypes and imidazoline-like binding sites in the rat brain. Br J Pharmacol 99:803-809
9. 2-adrenergic receptors in the antihypertensive responses evoked by central administration of clonidine analogs in conscious spontaneously hypertensive rats. J Pharmacol Exp Ther 273:1162-1171
10. Cedarbaum JM, Aghajanian GK (1976) Noradrenergic neurons of the locus coeruleus: inhibition by ephinephrine and activation by the a-antagonist piperoxane. Brain Res 112:413-419
11. Chan CKS, Sannajust F, Head GA (1996) Role of imidazoline receptors in the cardiovascular actions of moxonidine, rilmenidine and clonidine in conscious rabbits. J Pharmacol Exp Ther 276:411-420
12. Chiang C, Aston-Jones G (1993) Response of locus coeruleus neurons to footshock stimulation is mediated by neurons in the rostral ventral medulla. Neuroscience 53:705-715
13. Dahlström A, Fuxe K (1964) Evidence for the existence of monoamine-containing neurons in the central nervous system. Acta Physiol Scand 62:1-55
14. 1 receptor and the pharmacology of imidazolines. Cardiovasc Drug Ther 8:21-26
15. Elam M, Svensson TH, Thorén P (1985) Differentiated cardiovascular afferent regulation of locus coeruleus neurons and sympathetic nerves. Brain Res 358:77-84
16. Ennis M, Aston-Jones G (1986) A potent excitatory input to the nucleus locus coeruleus from the ventrolateral medulla. Neurosci Lett 71:299-305
17. Ennis M, Aston-Jones G (1988) Activation of locus coeruleus from nucleus paragigantocellularis: a new exicatory amino acid pathway in brain. J Neurosci 8:3644-3657
18. Ernsberger G, Giuliano R, Willette RN, Reis DJ (1990) Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla. J Pharmacol Exp Ther 253:408-418
19. 1-imidazoline receptors. J Cardiovasc Pharmacol 20:S1-S10
20. 1-imidazoline sites. J Pharmacol Exp Ther 264:172-182
21. 1-Imidazoline receptors definition, characterization distribution, and transrnembrane signalling. Ann NY Acad Sci 763:22-42
22. Escribá PV, Sastre M, Wang H, Regunathan S, Reis DJ, García-Sevilla JA (1994) Immunodetection of putative imidazoline receptor proteins in the human and rat brain and other tissues. Neurosci Lett 178:81-84
23. Foole SL, Bloom FE, Aston-Jones G (1983) Nucleus locus coeruleus: new evidence of anatomical and physiological specificity. Physiol Rev 63:844-914
24. Gómez RE, Ernsberger P, Feinland G, Reis DJ (1991) Rilmenidine lowers arterial pressure via imidazole receptors in brainstem C 1 area. Eur J Pharmacol 195:181-191
25. Greney H, Bennai F, Molines A, Belcourt A, Dontenwill M, Bousquet P (1994) Isolation of a human cerebral imidazoline-specific binding protein. Eur J Pharmacol 265:R1-R2
26. 2-adrenoceptors. Br J Pharmacol 110:1635-1639
27. 2-adrenoceptors and imidazoline binding sites: distribution of imidazoline binding sites in rat brain. Brain Res 514:15-21
28. 3H]rilmenidine. Brain Res 675:264-278
29. Li G, Regunathan S, Barrow CJ, Eshragi J, Cooper R, Reis DJ (1994) Agmatine: an endogenous clonidine-displacing substance in the brain. Science 263:966-969
30. 2 imidazoline receptors. Br J Pharmacol 116:1729-1736
31. Mallard NJ, Hudson AL, Nutt DJ (1992) Characterization and autoradiographical localization of non-adrenoceptor idazoxan binding sites in the rat brain. Br J Pharmacol 106:1019-1027
32. 1 imidazoline receptors in rat brain. Brain Res (in press)
33. 2 dopamine receptors by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in vivo: selective protection by neuroleptics. J Pharmacol Exp Ther 233:656-662
34. 2-adrenergic drugs also bind with high affinity to a nonadrenergic site. Mol Pharmacol 35:324-330
35. 3H]RX821002 (2-methoxy idazoxan) in the human and rat brains. J Pharmacol Exp Ther 264:1187-1197
36. 2-imidazoline sites in vitro and in vivo. J Neurochem 61:1602-1610
37. Page MR, Berridge CW, Foote SL, Valentino RJ (1993) Corticotropin-releasing factor in the locus coeruleus mediates EEG activation associated with hypotensive stress. Neurosci Lett 164:81-84
38. Parini A, Moudanos CG, Pizzinat N, Lanier SM (1996) The elusive family of imidazoline binding sites. Trends Pharmacol Sci 17:13-16
39. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates, 2nd edn. Academic Press, Orlando
40. Pineda J, Ugedo L, García-Sevilla JA (1993) Stimulatory effects of clonidine, cirazoline and rilmenidine on locus coeruleus noradrenergic neurons: possible involvement of imidazoline-preferring receptors. Naunyn-Schmiedeberg's Arch Pharmacol 348:134-140
41. Rasmussen K, Aghajanian GK (1989 a) Failure to block responses of locus coeruleus neurons to somatosensory stimuli by destruction of two major afferent nuclei. Synapse 4:162-164
42. Rasmussen K, Aghajanian GK (1989 b) Withdrawal-induced activation of locus coeruleus neurons in opiate-dependent rats: attenuation by lesions of the nucleus paragigantocellularis. Brain Res 505:346-350
43. Ruiz-Ortega JA, Ugedo L, Pineda J, García-Sevilla JA (1995) The stimulatory effect of clonidine through imidazoline receptors on locus coeruleus noradrenergic neurons is mediated by excitatory amino acids and modulated by serotonin. Naunyn-Schmiedeberg's Arch Pharmacol 352:121-126
44. Sannajust F, Head GA (1994) Rilmenidine-induced hypotension in conscious rabbits involves imidazoline-preferring receptors. J Cardiovasc Pharmacol 23:42-50
45. Singewald N, Schneider C, Philippu A (1994) Effects of neuroactive compounds, noxious and cardiovascular stimuli on the release of amino acids in the rat locus coeruleus. Neurosci Lett 180:55-58
46. 2-adrenoceplors modulating noradrenaline release? Eur J Pharmacol 213:305-307
47. Svensson TH (1987) Peripheral, autonomic regulation of locus coeruleus noradrenergic neurons in brain: putative implications for psychiatry and psychopharmacology. Psychopharmacology 92:1-7
48. Svensson TH, Bunney BS, Aghujaniun GK (1975) Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidine. Brain Res 92:291-306
49. Szabo B, Fröhlich R, Illes P (1996) No evidence for functional imidazoline receptors on locus coeruleus neurons. Naunyn-Schmiedeberg's Arch Pharmacol 353:557-563
50. Urban R, Szabo B, Starke K (1994) Is the sympathoinhibitory effect of rilmenidine mediated by alpha-2 adrenoceptors or imidazoline receptors? J Pharmacol Exp Ther 270:572-578
51. 2-adrenoceptors in the cardiovascular effects of moxonidine. Eur J Pharmacol 282:19-28
52. Urban R, Szabo B, Starke K (1995 b) Involvement of peripheral presynaptic inhibition in the reduction of sympathetic tone by moxonidine, rilmenidine and UK 14304. Eur J Pharmacol 282:29-37
53. Valentino RJ (1989) Corticotropin-releasing factor: putative neurotransmitter in the noradrenergic nucleus locus coeruleus. Psychopharmacol Bull 25:306-311
54. 2-adrenoceptor antagonists of the central sympatho-inhibitory effect of clonidine. Br J Pharmacol 117:587-593
55. Wang H, Regunathan S, Meeley MP, Reis DJ (1992) Isolation and characterization of imidazoline receptor protein from bovine adrenal chromaffin cells. Mol Pharmacol 42:792-801
56. 2-adrenoceptors which increase potassium conductance in rat locus coeruleus neurons. Neuroscience 14:95-101