Lung delivery of salbutamol by dry powder inhaler (Turbuhaler®) and small volume antistatic metal spacer (Airomir® CFC-free MDI plus NebuChamber®)

European Respiratory Journal

Volumn 10, Issue 8, 1997, Pages 1820-1823

  Lipworth, B J ^a   Clark, D J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Antistatic metal spacer; Bioavailability; Chlorofluorocarbon; Deposition; Dry powder inhaler; Salbutamol

Indexed keywords

SALBUTAMOL;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG UPTAKE; HUMAN; HUMAN EXPERIMENT; INHALATIONAL DRUG ADMINISTRATION; METERED DOSE INHALER; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, INHALATION; ADULT; ALBUTEROL; CROSS-OVER STUDIES; HUMANS; NEBULIZERS AND VAPORIZERS; OSMOLAR CONCENTRATION; POWDERS; SINGLE-BLIND METHOD; TIME FACTORS;

EID: 0030821173     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.97.10081820     Document Type: Article

References (18)

1. Partridge MR. Metered-dose inhalers and CFCs: what respiratory physicians need to know. Respir Med 1994; 88: 645-647.
2. Olsson B. Aerosol particle generation from dry powder inhalers: Can they equal pressurised metered-dose inhalers? J Aerosol Med 1995; 8 (Suppl. 3): S13-S18.
3. Borgstrom L, Bondesson E, Moren F, Trofast E, Newman SP. Lung deposition of budesonide inhaled via Turbuhaler®: a comparison with terbutaline sulphate in normal volunteers. Ear Respir J 1994; 7: 68-73.
4. Ekstrom T, Andersson A, Skedinger M, Lindbladh C, Stahl E. Dose potency relationship of terbutaline inhaled via Turbuhaler or via a pressurised metered-dose inhaler. Ann Allergy Asthma Immunol 1995; 74: 328-332.
5. Borgstrom L, Derom E, Stahl E, Wahlin-Boll E, Pauwels R. The inhalation device influences lung deposition and bronchodilating effect of terbutaline. Am J Respir Crit Care Med 1996; 153: 1636-1640.
6. Bisgaard H, Anhoj J, Klug B, Berg E. A nonelectrostatic spacer for aerosol delivery. Arch Dis Child 1995; 73: 226-230.
7. Wildhaber JH, Devadason SG, Eber E, et al. Effect of electrostatic charge, flow, delay and multiple actuations on the in vitro delivery of salbutamol from different small volume spacers for infants. Thorax 1996; 51: 985-988.
8. Barry PW, O'Callaghan C. The effect of delay, multiple actuations and spacer static charge on the in vitro delivery of budesonide from the Nebuhaler. Br J Clin Pharmacol 1995; 40: 76-78.
9. Barry PW, O'Callaghan C. Multiple actuations of salbutamol MDI into a spacer device reduce the amount of drug recovered in the respirable range. Ear Respir J 1994; 7: 1707-1709.
10. Clark DJ, Lipworth BJ. Effect of multiple actuations, delayed inhalation and antistatic treatment on the lung bioavailability of salbutamol via a spacer device. Thorax 1996; 51: 981-984.
11. Lipworth BJ. Pharmacokinetics of inhaled drugs. Br J Clin Pharmacol 1996; 42: 697-705.
12. Chrystyn H, Corlett SA, Silkstone V. Lung bioavailability of generic and innovator salbutamol MDIs. Thorax 1996; 51: 658.
13. 2-adrenoceptor responses and pharmacokinetics of salbutamol given by standard metered-dose inhaler and modified activator device. Br J Clin Pharmacol 1993; 36: 445-450.
14. Clark DJ, Lipworth BJ. Lung bioavailability of chlorofluorocarbon-free, dry powder and chlorofluorocarbon-containing formulations of salbutamol. Br J Clin Pharmacol 1996; 41: 247-249.
15. Clark DJ, Gordon-Smith J, McPhate G, Clark G, Lipworth BJ. Lung bioavailability of generic and innovator salbutamol metered-dose inhalers. Thorax 1996; 51: 325-326.
16. Lipworth BJ, McDevitt DG. Beta-adrenoceptor responses to inhaled salbutamol in normal subjects. Eur J Clin Pharmacol 1989; 36: 239-245.
17. Clark DJ, Lipworth BJ. Dose-response of inhaled drugs in asthma: an update. Clin Pharmacokinet 1997; 32: 58-74.
18. Newnham DM, Lipworth BJ. Nebuliser performance: pharmacokinetics and systemic effects of salbutamol given via a novel nebuliser delivery system (Ventstream). Thorax 1994; 49: 762-770.