Basic mechanisms of TMS

Journal of Clinical Neurophysiology

Volumn 19, Issue 4, 2002, Pages 322-343

  Terao, Yasuo ^a   Ugawa, Yoshikazu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

CBF, cerebral blood flow; CMAP, compound muscle action potential; EMG, electromyographic; FEF, frontal eye field; GABA, aminobutyric acid; MEP, motor evoked potential; PA, posteroanterior; PPC, posterior parietal cortex

Indexed keywords

BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN DEPTH STIMULATION; BRAIN FUNCTION; BRAIN RADIOGRAPHY; BRAIN REGION; ELECTRIC FIELD; ELECTROSTIMULATION; EVOKED MUSCLE RESPONSE; FACIAL NERVE; FACILITATION; HUMAN; MAGNETIC STIMULATION; MEDIAN NERVE; MOTOR CORTEX; MUSCLE ACTION POTENTIAL; NERVE STIMULATION; NEUROPHYSIOLOGY; NONHUMAN; PARIETAL LOBE; PYRAMIDAL TRACT; REVIEW; SPINAL CORD; SPINAL ROOT; TRANSCRANIAL MAGNETIC STIMULATION; ULNAR NERVE; VISUAL CORTEX;

EID: 0036423298     PISSN: 07360258     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004691-200208000-00006     Document Type: Review

References (176)

1. Albanese A, Daniele A, Lo Monaco M, et al. Postural axial tremor in a patient with cerebellar atrophy. Mov Disord 1992;7:273-80.
2. Allison T, McCarthy G, Luby M, Puce A, Spencer DD. Localization of functional regions of human mesial cortex by somatosensory evoked potential recording and by cortical stimulation. Electroencephalogr Clin Neurophysiol 1996;100:126-40.
3. Amassian VE, Cracco RQ. Human cerebral cortical responses to contralateral transcranial stimulation. Neurosurgery 1987;20:148-55.
4. Amassian VE, Cracco RQ, Maccabee PJ, Cracco JB, Rudell A, Eberle L. Suppression of visual perception by magnetic coil stimulation of human occipital cortex. Electroencephalogr Clin Neurophysiol 1989;74:458-62.
5. Amassian VE, Maccabee PJ, Cracco RQ, Cracco JB, Rudell AP, Eberle L. Measurement of information delays in human visual cortex with repetitive coil stimulation. Brain Res 1993;605:317-21.
6. Amassian VE, Maccabee PJ, Cracco RQ, et al. The polarity of the induced electric field influences magnetic coil inhibition of human visual cortex: Implications for the site of excitation. Electroencephalogr Clin Neurophysiol 1994;93:21-6.
7. Amassian VE, Somasundaram M, Rothwell JC, et al. Paraesthesias are elicited by single pulse, magnetic coil stimulation of motor cortex in susceptible humans. Brain 1991;114:2505-20.
8. Amassian VE, Stewart M, Quirk GJ, Rosenthal JL. Physiological basis of motor effects of a transient stimulus to cerebral cortex. Neurosurgery 1987;20:74-93.
9. Ashby P, Reynolds C, Wennberg R, Lozano AM, Rothwell JC. On the focal nature of inhibition and facilitation in the human motor cortex. Clin Neurophysiol 1999;110:550-5.
10. Barker AJ, Jalinous R, Freeston IL. Non-invasive stimulation of human motor cortex. Lancet 1985:ii:1106-7.
11. Bartholow R. Experimental investigations into the functions of the human brain. Am J Med Sci 1874;67:305-13.
12. Beckers G, Canavan AGM, Zangemeister WH, Hömberg V. Transcranial magnetic stimulation of human frontal and parietal cortex impairs programming of periodic saccades. Neuro-ophthalmology 1992;12:289-95.
13. Berardelli A, Inghilleri M, Cruccu G, Manfredi M. Descending volley after electrical and magnetic transcranial stimulation in man. Neurosci Lett 1990;112:54-8.
14. Berardelli A, Inghilleri M, Rothwell JC, et al. Facilitation of muscle evoked responses after repetitive cortical stimulation in man. Exp Brain Res 1998;122:79-84.
15. Boroojerdi B, Prager A, Muellbacher W, Cohen LG. Reduction of human visual cortex excitability using 1-Hz transcranial magnetic stimulation. Neurology 2000;54:1529-31.
16. Boyd SG, Rothwell JC, Cowan JMA, et al. A method of monitoring function in cortical pathways during scoliosis surgery with a note on motor conduction velocities. J Neurol Neurosurg Psychiatry 1986;49:251-7.
17. Burke D, Hicks R, Gandevia S, Stephen J, Woodforth I, Crawfold M. Direct comparison of corticospinal volleys in human subjects to transcranial magnetic and electrical stimulation. J Physiol (Lond) 1993;470:383-93.
18. Cantello R, Gianelli M, Civardi C, Mutani R. Magnetic brain stimulation: The silent period after the motor evoked potential. Neurology 1992;42:1951-9.
19. Chen R, Classen J, Gerloff C, et al. Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation. Neurology 1997;48:1398-403.
20. Chen R, Garg RR, Lozano AM, Lang AE. Effects of internal globus pallidus stimulation on motor cortex excitability. Neurology 2001;56:716-23.
21. Cocito D, Albera R, Bianco C, Luda di Cortemiglia E, Magnano M, De Mattei M. Transcranial magnetic stimulation of the facial nerve: Evaluation of a new method in neurophysiological study of Bell's palsy. Acta Otorhinolaryngol Ital 1990;10:475-86.
22. Cocito D, De Mattei M. Inadequacy of transcranial magnetic stimulation in the assessment of Bell's palsy. Electroencephalogr Clin Neurophysiol 1992;32:521-30.
23. Cohen LG, Bandinelli S, Sato S, Kufta C, Hallett M. Attenuation in detection of somatosensory stimuli by transcranial magnetic stimulation. Electroencephalogr Clin Neurophysiol 1991;81:366-76.
24. Cohen LG, Hallett M. Methodology for non-invasive mapping of human motor cortex with electrical stimulation. Electroencephalogr Clin Neurophysiol 1988;69:403-11.
25. Corthout E, Barker AT, Cowey A. Transcranial magnetic stimulation. Which part of the current waveform causes the stimulation? Exp Brain Res 2001;141:128-32.
26. Davey NJ, Romaiguère O, Maskill DW, Ellaway PH. Suppression of voluntary motor activity revealed using transcranial magnetic stimulation of the motor cortex in man. J Physiol 1994;418:13-23.
27. Day BL, Dressler D, Maertens de Noordhout A, et al. Electric and magnetic stimulation human motor cortex: Surface EMG and single motor unit responses. J Physiol (Lond) 1989;412:449-73.
28. Day BL, Rothwell JC, Thompson PD, et al. Motor cortex stimulation in intact man II: Multiple descending volleys. Brain 1987;110:1191-209.
29. Day BL, Rothwell JC, Thompson PD, et al. Delay in the execution of voluntary movement by electrical or magnetic brain stimulation in intact man. Evidence for the storage of motor programs in the brain. Brain 1989;112:649-63.
30. Dhuna AK, Gates JR, Pascual-Leone A. Transcranial magnetic stimulation in patients with epilepsy. Neurology 1991;41:1067-71.
31. Di Lazzaro V, Oliviero A, Mazzone P, et al. Comparison of descending volleys evoked by monophasic and biphasic magnetic stimulation of the motor cortex in conscious humans. Exp Brain Res 2001a;141:121-7.
32. Di Lazzaro V, Oliviero A, Profice P, et al. Descending spinal cord volleys evoked by transcranial magnetic and electrical stimulation of the motor cortex leg area in conscious humans. J Physiol 2001b;537:1047-58.
33. Di Lazzaro V, Restuccia D, Oliviero A, et al. Magnetic transcranial stimulation at intensities below active motor threshold activates intracortical inhibitory circuits. Exp Brain Res 1998;119:265-8.
34. Dingledine R, Korn SJ. γ-Aminobutyric acid uptake and the termination of inhibitory synaptic potential in the rat hippocampal slice. J Physiol 1985;366:387-409.
35. Edgley SA, Eyre JA, Lemon RN, Miller S. Excitation of the corticospinal tract by electromagnetic and electric stimulation of the scalp in the macaque monkey. J Physiol 1990;425:301-20.
36. Enomoto H, Ugawa Y, Hanajima R, et al. Decreased sensory cortical excitability after 1 Hz rTMS over the ipsilateral primary motor cortex. Clin Neurophysiol 2001;112:2154-8.
37. Epstein CM, Schwartzberg DG, Davey KR, Sudderth DB. Localizing the site of magnetic brain stimulation in humans. Neurology 1990;40:666-70.
38. Evans BA, Litchy WJ, Daube JR. The utility of magnetic stimulation for routine peripheral nerve conduction studies. Muscle Nerve 1988;11:1074-8.
39. Ferbert A, Priori A, Rothwell JC, Day BL, Colebatch JG, Marsden CD. Interhemispheric inhibition of the human motor cortex. J Physiol 1992;453:525-46.
40. Ferrier D. The Function of the Brain. London: Smith & Elder, 1876.
41. Fox P, Ingham R, George MS, et al. Imaging human intra-cerebral connectivity by PET during TMS. Neuroreport 1997;8:2787-91.
42. Fritsch G, Hitzig E. Über diie elecktrische erregbarkeit des gro β hirns. Arch Anat Physiol (Wiss. Med.) 1870;37:300-32.
43. Furubayashi T, Ugawa Y, Terao Y, et al. The human hand motor area is transiently suppressed by an unexpected auditory stimulus. Clin Neurophysiol 2000;111:178-83.
44. George MS, Wassermann EM, Kimbrell TA, et al. Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: A placebo-controlled crossover trial. Am J Psychiatry 1997;154:1752-6.
45. George MS, Wassermann EM, Williams WA, et al. Daily repetitive transcranial magnetic stimulation improves mood in depression. Neuroreport 1995;6:1853-6.
46. Gironell A, Kulisevsky J, Sedano BP, et al. Effects of internal globus pallidus stimulation on motor cortex excitability. Neurology 2002;58:669-70.
47. Goldberg ME, Bruce CJ. Primate frontal eye fields. III. Maintenance of a spatially accurate saccade signal. J Neurophysiol 1990;64:489-508.
48. Greenberg BD, George MS, Martin JD, et al. Effect of prefrontal repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: A preliminary study. Am J Psychiatry 1997;154:867-9.
49. Gualtierotti T, Paterson AS. Electric stimulation of the unexpected cerebral cortex. J Physiol 1954;125:278-91.
50. Guggisberg AG, Dubach P, Hess CW, Wuthrich C, Mathis J. Motor evoked potentials from masseter muscle induced by transcranial magnetic stimulation of the pyramidal tract: The importance of coil orientation. Clin Neurophysiol 2001;112:2312-9.
51. Hanajima R, Ugawa Y, Machii K, et al. Interhemispheric facilitation of the hand motor area in humans. J Physiol 2001;531:849-59.
52. Hanajima R, Ugawa Y, Terao Y, et al. Mechanisms of intracortical I-wave facilitation elicited with paired-pulse magnetic stimulation in humans. J Physiol 2002;538:253-61.
53. Hanajima R, Ugawa Y, Terao Y, et al. Paired-pulse magnetic stimulation of the human motor cortex: Differences among I waves. J Physiol 1998;509:607-18.
54. Hern J, Landgren S, Phillips C. Selective excitation of corticofugal neurons by sufface-anodal stimulation of the baboon's motor cortex. J Physiol 1962;161:73-90.
55. Hess CW, Mills KR, Murray NM. Responses in small hand muscles from magnetic stimulation of the human brain. J Physiol 1987;388:397-419.
56. Hicks R, Burke D, Stephen J, Woodforth I, Crawford M. Corticospinal volleys evoked by electrical stimulation of human motor cortex after withdrawal of volatile anaesthetics. J Physiol 1992;456:393-404.
57. Houlden DA, Schwartz ML, Tator CH, Ashby P, MacKay WA. Spinal cord-evoked potentials and muscle responses evoked by transcranial magnetic stimulation in 10 awake human subjects. J Neurosci 1999;19:1855-62.
58. Hufnagel A, Elger CE. Induction of seizures by transcranial magnetic stimulation in epileptic patients. J Neurol 1991;238:109-10.
59. Iles JF, Cummings R. Electrical and magnetic stimulation of motor cortex in man. J Physiol (Lond) 1992;446:223P.
60. Inghilleri M, Berardelli A, Cruccu G, Priori A, Manfredi M. Corticospinal potentials after transcranial stimulation in humans. J Neurol Neurosurg Psychiatry 1989;52:970-4.
61. Inghilleri M, Berardelli A, Marchetti P, Manfredi M. Effects of diazepam, baclofen and thiopental on the silent period evoked by transcranial magnetic stimulation. Exp Brain Res 1996;109:467-72.
62. Iwata NK, Hanajima R, Ugawa Y, et al. Facilitatory effect on the motor cortex by electrical stimulation over the cerebellum in humans [abstract]. Clin Neurophysiol 1999;110(Suppl 1):S85.
63. Iwata NK, Ugawa Y, Watanabe E, Yamashita Y, Koizumi H, Kanazawa I. Interhemispheric connection between bilateral hand motor areas studied with near-infrared spectroscopic (NIRS) mapping and transcranial magnetic stimulation (TMS) [abstract]. Neuroimage 2000;5:S520.
64. Kamitani Y, Shimojo S. Manifestation of scotomas created by transcranial magnetic stimulation of human visual cortex. Nat Neurosci 1999;2:767-71.
65. Kammer T, Beck S, Erb M, Grodd W. The influence of current direction on phosphene thresholds evoked by transcranial magnetic stimulation. Clin Neurophysiol 2001a;112:2015-21.
66. Kammer T, Beck S, Thielscher A, Laubis-Herrmann U, Topka H. Motor thresholds in humans: A transcranial magnetic stimulation study comparing different pulse waveforms, current directions and stimulator types. Clin Neurophysiol 2001b;112:250-8.
67. Kaneko K, Kawai S, Fuchigami Y, Shiraishi G, Ito T. Intracortical facilitation of the muscle response after transcranial magnetic double stimulation. Muscle Nerve 1996;19:1043-145.
68. Katayama Y, Tsubokawa T, Maejima S, Hirayama T, Yamamoto T. Corticospinal direct response in humans: Identification of the motor cortex during intracranial surgery under general anaesthesia. J Neurol Neurosurg Psychiatry 1988;51:50-9.
69. Kobayashi M, Ohira T, Nakamura A, Gotoh K, Toya S. Bony foramina facilitate magnetic stimulation: An experimental cat sciatic nerve model. Electroencephalogr Clin Neurophysiol 1997;105:79-85.
70. Krnjevíc K, Randic M, Straughan DW. An inhibitory process in the cerebral cortex. J Physiol 1966a;184:16-48.
71. Krnjevíc K, Randic M, Straughan DW. Nature of the cortical inhibitory process. J Physiol 1966b;184:49-77.
72. Krnjevíc K, Randic M, Straughan DW. Pharmacology of cortical inhibition. J Physiol 1966c;184:78-105.
73. Krnjevíc K, Schwartz S. Is gamma-aminobutyric acid an inhibitory transmitter? Nature 1966;211:1372-4.
74. Kujirai T, Caramia MD, Rothwell JC, et al. Corticocortical inhibition in human motor cortex. J Physiol 1993;471:501-19.
75. Landgren S, Phillips CG, Porter R. Minimal synaptic actions of pyramidal impulses on some alpha motoneurones of the baboon's hand and forearm. J Physiol 1962;161:91-111.
76. Li J, Olson J, Anand S, Hotson J. Rapid-rate transcranial magnetic stimulation of human frontal cortex can evoke saccades under facilitating conditions. Electroencephalogr Clin Neurophysiol 1997;105:246-54.
77. Lueck CJ, Ingram DA, Crawford TJ, Kennard C. The effect of transcranial magnetic stimulation on saccades in man [abstract]. J Physiol (Lond) 1990;434:15P.
78. Maccabee PJ, Amassian VE, Cracco RQ, Cracco JB, Anziska BJ. Intracranial stimulation of facial nerve in humans with the magnetic coil. Electroencephalogr Clin Neurophysiol 1988;70:350-4.
79. Maccabee PJ, Amassian VE, Eberle LP, Cracco RQ. Magnetic coil stimulation of straight and bent amphibian and mammalian peripheral nerve in vitro: Locus of excitation. J Physiol 1993;460:201-19.
80. Maccabee PJ, Nagarajan SS, Amassian VE, et al. Influence of pulse sequence, polarity and amplitude on magnetic stimulation of human and porcine peripheral nerve. J Physiol 1998;513:571-85.
81. Machii K, Ugawa Y, Terao Y, et al. Input-output organization in the foot area of the human motor cortex. Clin Neurophysiol 1999;110:1315-20.
82. Maeda F, Keenan JP, Tormos JM, Topka H, Pascual-Leone A. Inter-individual variability of the modulatory effects of repetitive transcranial magnetic stimulation on cortical excitability. Exp Brain Res 2000;133:425-30.
83. Maertens de Noordhout A, Rothwell JC, Day BL, et al. Effect of digital nerve stimuli on responses to electrical or magnetic stimulation of the human brain. J Physiol 1992;447:535-48.
84. Marg E, Rudiak D. Phosphenes induced by magnetic stimulation over the occipital brain: Description and probable site of stimulation. Optom Vis Sci 1994;71:301-11.
85. Mathis J, Seemann U, Weyh T, Jakob C, Struppler A. The boundary effect in magnetic stimulation. Analysis at the peripheral nerve. Electroencephalogr Clin Neurophysiol 1995;97:238-45.
86. Mavroudakis N, Caroyer JM, Brunko E, Zegers de Beyl D. Abnormal motor evoked responses to transcranial magnetic stimulation in focal dystonia. Neurology 1995;45:1671-7.
87. McCormick DA. Neurotransmitter actions in the thalamus and cerebral cortex. J Clin Neurophysiol 1992;9:212-23.
88. Merton PA, Morton HB. Stimulation of the cerebral cortex in the intact human subject. Nature 1980;285:227.
89. Metson R, Rebeiz E, West C, Thornton A. Magnetic stimulation of the facial nerve. Laryngoscope 1991;101:25-30.
90. Meyer G. Forms and spatial arrangement of neurons in the primary motor cortex of man. J Comp Neurol 1987;262:420-8.
91. Meyer BU, Röricht S, Grafin von Einsiedel H, Kruggel F, Weindl A. Inhibitory and excitatory interhemispheric transfers between motor cortical areas in normal humans and patients with abnormalities of the corpus callosum. Brain 1995;118:429-40.
92. Meyer BU, Röricht S, Woiciechowsky C. Topography of fibers in the human corpus callosum mediating interhemispheric inhibition between the motor cortices. Ann Neurol 1998;43:360-9.
93. Mills KR. Biophysics of transcranial magnetic stimulation. In: Mills KR, ed. Magnetic Stimulation of the Human Nervous System. Oxford: Oxford University Press, 1999:7-26.
94. Mills KR, Boniface SJ, Schubert M. Magnetic brain stimulation with a double coil: The importance of coil orientation. Electroencephalogr Clin Neurophysiol 1992;85:17-21.
95. Münchau A, Bloem BR, Irlbacher K, Trimble MR, Rothwell JC. Functional connectivity of human premotor and motor cortex explored with repetitive transcranial magnetic stimulation. J Neurosci 2002;22:554-61.
96. Müri RM, Hess CW, Meienberg O. Transcranial stimulation of the human frontal eye field by magnetic pulses. Exp Brain Res 1991;86:219-23.
97. Müri RM, Vermersch A-I, Rivaud S, Gaymard B, Pierrot-Deseilligny C. Effects of single-pulse transcranial magnetic stimulation over the prefrontal and posterior parietal cortices during memory-guided saccades in humans. J Neurophysiol 1996;76:2102-6.
98. Nakamura H, Kitagawa H, Kawaguchi Y, Tsuji H. Intracortical facilitation and inhibition after transcranial magnetic stimulation in conscious humans. J Physiol 1997;498:817-23.
99. Nakamura H, Kitagawa H, Kawaguchi Y, Tsuji H. Direct and indirect activation of human corticospinal neurons by transcranial magnetic and electrical stimulation. Neurosci Lett 1996;210:45-8.
100. Nielsen JF, Klemar B, Hansen HJ, Sinkjaer T. A new treatment of spasticity with repetitive magnetic stimulation in multiple sclerosis. J Neurol Neurosurg Psychiatry 1995a;58:254-5.
101. Nielsen J, Petersen N, Ballegaard M. Latency of effects evoked by electrical and magnetic brain stimulation in lower limb motoneurons in man. J Physiol (Lond) 1995b;484:791-802.
102. Nielsen JF, Sinkjaer T, Jakobsen J. Treatment of spasticity with repetitive magnetic stimulation; a double-blind placebo-controlled study. Multiple Sclerosis 1996;2:227-32.
103. Ohki Y, Suzuki T, Ugawa Y, Uesaka Y, Sakai K, Kanazawa I. Excitation of the motor cortex associated with the E2 phase of cutaneous reflexes in man. Brain Res 1994;633:343-7.
104. Oishi M, Takasu T. Large and small coils in magnetic stimulation of the proximal portion of the facial nerve. Eur Neurol 1993;33:34-7.
105. Okabe S, Ugawa Y, Hanajima R, Shiio Y, Iwata N, Kanazawa I. A new magnetic coil for stimulating the peripheral nerve. Presented at the 42nd Annual Meeting of the Japanese Neurological Society. Tokyo, Japan. 2001.
106. Olney RK, So YT, Goodin DS, Aminoff MJ. A comparison of magnetic and electrical stimulation of peripheral nerves. Muscle Nerve 1990;20:823-32.
107. Oyachi H, Ohtsuka K. Transcranial magnetic stimulation of the posterior parietal cortex degrades accuracy of memory-guided saccades in humans. Invest Ophthalmol Vis Sci 1995;36:1441-9.
108. Palmer E, Cafarelli E, Ashby P. The processing of human ballistic movements explored by stimulation over the cortex. J Physiol (Lond) 1994;481:509-20.
109. Patton HD, Amassian VE. The pyramidal tract: Its excitation and functions. In: Field J, ed. Handbook of Physiology-Neurophysiology. Vol II. Washington, DC: American Physiological Society, 1960:837-61.
110. Patton HD, Amassian VE. Single- and multiple-unit analysis of cortical stage of pyramidal tract activation. J Neurophysiol 1954;17:345-63.
111. Paus T. Location and function of the human frontal eye-field: A selective review. Neuropsychologia 1996;34:475-83.
112. Paus T, Jech R, Thompson CJ, Comeau R, Peters T, Evans AC. Dose-dependent reduction of cerebral blood flow during rapid-rate transcranial magnetic stimulation of the human sensorimotor cortex. J Neurophysiol 1998;79:1102-7.
113. Paus T, Jech R, Thompson CJ, Comeau R, Peters T, Evans AC. Transcranial magnetic stimulation during positron emission tomography: A new method for studying connectivity of the human cerebral cortex. J Neurosci 1997;17:3178-84.
114. Pascual-Leone A, Tormos JM, Keenan J, Tarazona F, Canete C, Catala MD. Study and modulation of human cortical excitability with transcranial magnetic stimulation. J Clin Neurophysiol 1998;15:333-43.
115. Pascual-Leone A, Valls-Sole J, Brasil-Neto JP, Cohen LG, Hallett M. Seizure induction and transcranial magnetic stimulation. Lancet 1992;339:997.
116. Pascual-Leone A, Valls-Sole J, Wassermann EM, Hallett M. Responses to rapid-rate transcranial magnetic stimulation of the human motor cortex. Brain 1994;117:847-58.
117. Penfield W, Jasper HH. Epilepsy and the Functional Anatomy of the Human Brain. Boston: Little Brown, 1954.
118. Philips CG, Porter R. Unifocal and bifocal stimulation of the motor cortex. J Physiol 1962;162:532-8.
119. Philips CG, Porter R. The pyramidal projection to motoneurons of some muscle groups of the baboon's forelimb. In: Eccles JP, Shadé JP, eds. Physiology of Spinal Neurons. Progress in Brain Research. Vol. 12. Amsterdam: Elsevier, 1964:222-45.
120. Priori A, Berardelli A, Inghilleri M, Accornero N, Manfredi M. Motor cortical inhibition and the dopaminergic system. Pharmacological changes in the silent period after transcranial brain stimulation in normal subjects, patients with Parkinson's disease and drug-induced parkinsonism. Brain 1994;117:317-23.
121. Priori A, Berardelli A, Mercuri B, Inghilleri M, Manfredi M. The effect of hyperventilation on motor cortical inhibition in humans: A study of the electromyographic silent period evoked by transcranial magnetic stimulation. Electroencephalogr Clin Neurophysiol 1995;97:69-72.
122. Priori A, Bertolasi L, Dressler D, et al. Transcranial electric and magnetic stimulation of the leg area of the human motor cortex: Single motor unit and surface EMG responses in the tibialis anterior muscle. Electroencephalogr Clin Neurophysiol 1993a;89:131-7.
123. Priori A, Bertolasi L, Rothwell JC, Day BL, Marsden CD. Some saccadic eye movements can be delayed by transcranial magnetic stimulation of the cerebral cortex in man. Brain 1993b;116:355-67.
124. Robertson EM, Tormos JM, Maeda F, Pascual-Leone A. The role of the dorsolateral prefrontal cortex during sequence learning is specific for spatial information. Cereb Cortex 2001;11:628-35.
125. Rösler KM, Hess CW, Heckmann R, Ludin HP. Significance of shape and size of the stimulating coil in magnetic stimulation of the human motor cortex. Neurosci Lett 1989a;100:347-52.
126. Rösler KM, Hess CW, Schmid UD. Investigation of facial motor pathway by electrical and magnetic stimulation: Sites and mechanisms of excitation. J Neurol Neurosurg Psychiatry 1989b;52:1149-56.
127. Rothwell JC. Techniques and mechanisms of action of transcranial stimulation of the human motor cortex. J Neurosci Methods 1997;74:113-221.
128. Rothwell JC, Burke D, Hicks R, Stephen J, Woodforth I, Crawford M. Transcranial electric stimulation of the human motor cortex in man: Further evidence for the site of activation. J Physiol 1994;481:243-50.
129. Rothwell JC, Thompson PD, Day BL, Boyd S, Marsden CD. Stimulation of the human motor cortex through the scalp. Exp Physiol 1991;76:159-200.
130. Rudiak D, Marg E. Finding the depth of magnetic brain stimulation: A re-evaluation. Elecrroencephalogr Clin Neurophysiol 1994;93:358-71.
131. Sakai K, Ugawa Y, Terao Y, Hanajima R, Furubayashi T, Kanazawa I. Preferential activation of different I waves by transcranial magnetic stimulation with a figure-of-eight-shaped coil. Exp Brain Res 1997;113:24-32.
132. Schriefer TN, Mills KR, Murray NM, Hess CW. Evaluation of proximal facial nerve conduction velocity by transcranial magnetic stimulation. J Neurol Neurosurg Psychiatry 1988;51:60-6.
133. Seki Y, Krain L, Yamada T, Kimura J. Transcranial magnetic stimulation of the facial nerve: Recording technique and estimation of the stimulated site. Neurosurgery 1990;26:286-90.
134. Seyal M, Siddiqui I, Hundal NS. Suppression of spatial localization of a cutaneous stimulus following transcranial magnetic pulse stimulation of the sensorimotor cortex. Electroencephalogr Clin Neurophysiol 1997;105:24-8.
135. Siebner HR, Peller M, Willoch F, et al. Lasting cortical activation after repetitive TMS of the motor cortex: A glucose metabolic study. Neurology 2000;54:956-63.
136. Stokic DS, McKay WB, Scott L, Sherwood AM, Dimitrijevic MR. Intracortical inhibition of lower limb motor-evoked potentials after paired transcranial magnetic stimulation. Exp Brain Res 1997;117:437-43.
137. Strafella AP, Paus T. Cerebral blood-flow changes induced by paired-pulse transcranial magnetic stimulation of the primary motor cortex. J Neurophysiol 2001;85:2624-9.
138. Strafella AP, Paus T, Barrett J, Dagher A. Repetitive transcranial magnetic stimulation of the human prefrontal cortex induces dopamine release in the caudate nucleus. J Neurosci 2001;21:RC157.
139. Sugishita M, Takayama Y. Paraesthesia elicited by repetitive magnetic stimulation of the postcentral gyrus. Neuroreport 1993;4:569-70.
140. Terao Y, Fukuda H, Ugawa Y, et al. Visualization of the information flow through human oculomotor cortical regions by transcranial magnetic stimulation. J Neurophysiol 1998a;80:936-46.
141. Terao Y, Ugawa Y, Hanajima R, et al. Predominant activation of II-waves from the leg motor area by transcranial magnetic stimulation. Brain Res 2000;859:137-46.
142. Terao Y, Ugawa Y, Hanajima R, et al. Motor cortical reflex myoclonus - A case study with MEG. Electroencephalogr Clin Neurophysiol 1997;102:505-11.
143. Terao Y, Ugawa Y, Sakai K, et al. Localizing the site of magnetic brain stimulation by functional MRI. Exp Brain Res 1998b;121:145-52.
144. Terao Y, Ugawa Y, Sakai K, Uesaka Y, Kanazawa I. Transcranial magnetic stimulation of the leg area of motor cortex in humans. Acta Neurol Scand 1994;89:378-83.
145. Thickbroom GW, Stell R, Mastaglia FL. Transcranial stimulation of the human frontal eye field. J Neurol Sci 1996;144:114-8.
146. Thompson SM, Gähwiler BH. Effects of the GABA uptake inhibitor tiagabine on inhibitory synaptic potentials in rat hippocampal slice cultures. J Neurophysiol 1992;67:1698-701.
147. Tokimura H, Ridding MC, Tokimura Y, Amassian VE, Rothwell JC. Short latency facilitation between pairs of magnetic stimuli applied to the human motor cortex. Electroencephalogr Clin Neurophysiol 1996;101:263-72.
148. Tokimura H, Tokimura Y, Asakura T. Transcranial magnetic stimulation of facial nerve with a figure 8 coil. Muscle Nerve 1993a;16:882-3.
149. Tokimura H, Yamagami M, Tokimura Y, Asakura T, Atsuchi M. Transcranial magnetic stimulation excites the root exit zone of the facial nerve. Neurosurgery 1993b;32:414-6.
150. Touge T, Gerschlager W, Brown P, Rothwell JC. Are the after-effects of low-frequency rTMS on motor cortex excitability due to changes in the efficacy of cortical synapses? Clin Neurophysiol 2001;112:2138-45.
151. Ueno S, Tashiro T, Harada K. Localized stimulation of neural tissues in the brain by means of paired configuration of time-varying magnetic fields. J Appl Physics 1988;64:5862-4.
152. Ugawa Y, Day BL, Rothwell JC, Thompson PD, Merton PA, Marsden CD. Modulation of motor cortical excitability by electrical stimulation over the cerebellum in man. J Physiol 1991;441:57-72.
153. Ugawa Y, Genba K, Mannen T, Kanazawa I. Stimulation of corticospinal pathways at the level of the pyramidal decussation in neurological disorders. Brain 1992;115:1947-61.
154. Ugawa Y, Genba K, Shimizu K, Kanazawa I. Electrical stimulation of the human descending motor tracts at several levels. Can J Neurol Sci 1995a;322:36-42.
155. Ugawa Y, Genba-Shimizu K, Kanazawa I. Suppression of motor cortical excitability by electrical stimulation over the cerebellum in Fisher's syndrome. J Neurol Neurosurg Psychiatry 1994a;57:1275-6.
156. Ugawa Y, Genba-Shimizu K, Rothwell JC, Iwata M, Kanazawa I. Suppression of motor cortical excitability by electrical stimulation over the cerebellum in ataxia. Ann Neurol 1994b;36:90-6.
157. Ugawa Y, Hanajima R, Kanazawa I. Interhemispheric facilitation of the hand area of the human motor cortex. Neurosci Lett 1993;160:153-5.
158. Ugawa Y, Rothwell JC, Day BL, Thompson PD, Marsden CD. Percutaneous electrical stimulation of corticospinal pathways at the level of the pyramidal decussation in humans. Ann Neurol 1991;29:418-27.
159. Ugawa Y, Rothwell JC, Day BL, Thompson PD, Marsden CD. Magnetic stimulation over the spinal enlargements. J Neurol Neurosurg Psychiatry 1989;52:1025-32.
160. Ugawa Y, Terao Y, Nagai C, Nakamura K, Kanazawa I. Electrical stimulation of the cerebellum normally suppresses motor cortical excitability in a patient with ataxia due to a lesion of the middle cerebellar peduncle. Eur Neurol 1995b;35:243-4.
161. Ugawa Y, Uesaka Y, Terao Y, Hanajima R, Kanazawa I. Magnetic stimulation of the descending and ascending tracts at the foramen magnum level. Electroencephalogr Clin Neurophysiol 1997;105:128-31.
162. Ugawa Y, Uesaka Y, Terao Y, Hanajima R, Kanazawa I. Magnetic stimulation of corticospinal pathways at the foramen magnum level in humans. Ann Neurol 1994c;36:618-24.
163. Valls-Solé J, Alvarez R, Tolosa ES. Human motor evoked responses to paired transcranial magnetic stimulation. Electroencephalogr Clin Neurophysiol 1992;85:355-64.
164. Wassermann EM. Risk and safety of repetitive transcranial magnetic stimulation: Reported and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. Electroencephalogr Clin Neurophysiol 1998;108:1-16.
165. Wassermann EM, Cohen LG, Flitman SS, Chen R, Hallett M. Seizures in healthy people with repeated "safe" trains of transcranial magnetic stimulation. Lancet 1996a;347:825.
166. Wassermann EM, Grafman J, Berry C, et al. Use and safety of a new repetitive transcranial magnetic stimulation. Electroencephalogr Clin Neurophysiol 1996b;101:412-7.
167. Wassermann EM, Pascual-Leone A, Hallett M. Cortical motor representation of the ipsilateral hand and arm. Exp Brain Res 1994;100:121-32.
168. Werhahn K, Fong JKY, Meyer B-U, et al. The effect of magnetic coil orientation of the latency of surface EMG and single motor unit responses in the first dorsal interosseous muscle. Electroencephalogr Clin Neurophysiol 1994;93:138-46.
169. Werhahn KJ, Kunesch E, Noachtar S, Benecke R, Classen J. Differential effects on motorcortical inhibition induced by blockade of GABA uptake in humans. J Physiol 1999;517:591-7.
170. Wessel K, Kömpf D. Transcranial magnetic stimulation: Lack of oculomotor response. Exp Brain Res 1991;86:216-8.
171. Wilson SA, Thickbroom GW, Mastaglia FL. Topography of excitatory and inhibitory muscle responses evoked by transcranial magnetic stimulation in the human motor cortex. Neurosci Lett 1993;154:52-6.
172. Yunokuchi K, Cohen D. Developing a more focal magnetic stimulator. Part II: Fabricating coils and measuring induced current distributions. J Clin Neurophysiol 1991;8:112-20.
173. Zangemeister WH, Canavan AGM, Hömberg V. Frontal and parietal transcranial magnetic stimulation (TMS) disturbs programming of saccadic eye movements. J Neurol Sci 1995;133:42-52.
174. Ziemann U, Lonnecker S, Steinhoff BJ, Paulus W. The effect of lorazepam on the motor cortical excitability in man. Exp Brain Res 1996;109:127-35.
175. Ziemann U, Tergau F, Wassermann EM, Wischer S, Hildebrandt J, Paulus W. Demonstration of facilitatory I wave interaction in the human motor cortex by paired transcranial magnetic stimulation. J Physiol 1998a;511:181-90.
176. Ziemann U, Tergau F, Wischer S, Hildebrandt J, Paulus W. Pharmacological control of facilitatory I-wave interaction in the human motor cortex. A paired transcranial magnetic stimulation study. Electroencephalogr Clin Neurophysiol 1998b;109:321-30.