Ketoconazole suppresses prostaglandin E2-induced cyclooxygenase-2 expression in human epidermoid carcinoma A-431 cells

Journal of Investigative Dermatology

Volumn 119, Issue 1, 2002, Pages 174-181

  Kanda, Naoko ^a   Watanabe, Shinichi ^a  

^a TEIKYO UNIVERSITY   (Japan)

Author keywords

Activating transcription factor 1; Cyclic adenosine monophosphate response element binding protein; Phosphorylation

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC AMP DERIVATIVE; CYCLOOXYGENASE 2; KETOCONAZOLE; MESSENGER RNA; PROSTAGLANDIN E2; TRANSCRIPTION FACTOR;

CARCINOMA CELL; CONFERENCE PAPER; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GENE DELETION; HUMAN; HUMAN CELL; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA;

EID: 0036421806     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2002.01804.x     Document Type: Conference Paper

References (44)

1. Aronica SM, Kraus WL, Katzenellenbogen BS: Estrogen action via the cAMP signaling pathway. Stimulation of adenylate cyclase and cAMP-regulated gene transcription. Proc Natl Acad Sci USA 91:8517-8521, 1994
2. Bettens JR, Loots W, Somers Y, Coene MC, de Clerck F: Ketoconazole inhibits the biosynthesis of leukotrienes in vitro and in vivo. Biochem Pharmacol 35:883-891, 1986
3. 2 on interleukin-1 β-induced cyclooxygenase-2 expression in human airway smooth-muscle cells. Am J Respir Crit Care Med 162:2272-2277, 2000
4. Caivano M, Gorgoni B, Cohen P, Poli V: The induction of cyclooxygenase-2 mRNA in macrophages is biphasic and requires both CCAAT enhancer-binding protein β (C/EBPβ) and C/EBPδ transcription factors. J Biol Chem 276:48693-48701, 2001
5. Choi EJ, Xia Z, Storm DR: Stimulation of the type III olfactory adenylyl cyclase by calcium and calmodulin. Biochemistry 31:6492-6498, 1992
6. 2a-receptors. Glia 18:152-160, 1996
7. Gallo O, Franchi A, Magnelli L, et al: Cyclooxygenase-2 pathway correlates with VEGF expression in head and neck cancer. Implications for tumor angiogenesis and metastasis. Neoplasia 3:53-61, 2001
8. Garcia MA, Campillos M, Marina A, Valdivieso F, Vazquez J: Transcription factor AP-2 activity is modulated by protein kinase A-mediated phosphorylation. FEBS Lett 444:27-31, 1999
9. Higashi Y, Kanekura T, Kanzaki T: Enhanced expression of cyclooxygenase (COX)-2 in human skin epidermal cancer cells: Evidence for growth suppression by inhibiting COX-2 expression. Int J Cancer 86:667-671, 2000
10. 2, and nonsteroidal anti-inflammatory drugs. Biochem Biophys Res Commun 278:790-796, 2000
11. Hsueh Y-P, Lai M-Z: c-Jun N-terminal kinase but not mitogen-activated protein kinase is sensitive to cAMP inhibition in T lymphocytes. J Biol Chem 270:18094-18098, 1995
12. Inoue H, Tanabe T: Transcriptional role of the nuclear factor κB site in the induction by lipopolysaccharide and suppression by dexamethasone of cyclooxygenase-2 in U937 cells. Biochem Biophys Res Commun 244:143-148, 1998
13. Inoue H, Nanayama T, Hara S, Yokoyama C, Tanabe T: The cyclic AMP response element plays an essential role in the expression of the human prostaglandin-endoperoxide synthase 2 gene in differentiated U937 monocytic cells. FEBS Lett 350:51-54, 1994
14. Inoue H, Yokoyama C, Hara S, Tone Y, Tanabe T: Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. Involvement of both nuclear factor for interleukin-6 expression site and cAMP response element. J Biol Chem 270:24965-24971, 1995
15. Janssen PAJ, Vanden Bossche HFA, van Wauwe JP, Cauwenbergh GFMJ, Degreef HJ: The role of cytochrome P-450 in dermatology. Int J Dermatol 28:493-496, 1989
16. Kagoura M, Toyoda M, Matsui C, Morohashi M: Immunohistochemical expression of cyclooxygenase-2 in skin cancers. J Cutan Pathol 28:298-302, 2001
17. Kanda N, Enomoto U, Watanabe S: Anti-mycotics suppress interleukin-4 and interleukin-5 production in anti-CD3 plus anti-CD28-stimulated T cells from patients with atopic dermatitis. J Invest Dermatol 117:1635-1646, 2001
18. 2 analogue (U46619) and basic fibroblast growth factor in porcine aortic smooth-muscle cells. Biochem J 326:593-599, 1997
19. Kim Y, Fischer SM: Transcriptional regulation of cyclooxygenase-2 in mouse skin carcinoma cells. Regulatory role of CCAAT/enhancer-binding proteins in the differential expression of cyclooxygenase-2 in normal and neoplastic tissues. J Biol Chem 273:27686-27694, 1998
20. Loose DS, Kan PB, Hirst MA, Marcus RA, Feldman D: Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes. J Clin Invest 71:1495-1499, 1983
21. Maehara K, Hasegawa T, Isobe K: A NF-κB p65 subunit is indispensable for activation manganese superoxide: Dismutase gene transcription mediated by tumor necrosis factor-α. J Cell Biochem 77:474-486, 2000
22. 2 regulation of cyclooxygenase expression in keratinocytes is mediated via cyclic nucleotide-linked prostaglandin receptors. J Lipid Res 41:873-881, 2000
23. Meade EA, McIntyre TM, Zimmerman GA, Prescott SM: Peroxisome proliferators enhance cyclooxygenase-2 expression in epithelial cells. J Biol Chem 274:8328- 8334, 1999
24. Muller-Decker K, Scholz K, Marks F, Furstenberger G: Differential expression of prostaglandin H synthase isozymes during multistage carcinogenesis in mouse epidermis. Mol Carcinog 12:31-41, 1995
25. Muller-Decker K, Reinerth G, Krieg P, et al: Prostaglandin-H-synthase isozyme expression in normal and neoplastic human skin. Int J Cancer 82:648-656, 1999
26. Negishi M, Sugimoto Y, Ichikawa A: Prostanoid receptors and their biological actions. Prog Lipid Res 32:417-434, 1993
27. Peri KG, Almazan G, Varma DR, Chemtob S: A role for protein kinase Cα in stimulation of prostaglandin G/H synthase-2 transcription by 14,15-epoxyeicosatrienoic acid. Biochem Biophys Res Commun 244:96-101, 1998
28. Pilbeam CC, Raisz LG, Voznesensky O, Alander CB, Delman BN, Kawaguchi H: Autoregulation of inducible prostaglandin G/H synthase in osteoblastic cells by prostaglandins. J Bone Miner Res 10:406-414, 1995
29. Reddy AT, Wadleigh DJ, Herschman HR: Transcriptional regulation of the cyclooxygenase-2 gene in activated mast cells. J Biol Chem 275:3107-3113, 2000
30. Ristimaki A, Garfinkel S, Wessendorf J, Maciag T, Hla T: Induction of cyclooxygenase-2 by interleukin-1α. Evidence for post-transcriptional regulation. J Biol Chem 269:11769-11775, 1994
31. Salomon Y, Londons D, Rodbell M: A highly sensitive adenylate cyclase assay. Anal Biochem 58:541-548, 1974
32. 2-)terminal kinase groups of mitogen-activated protein kinases. J Biol Chem 271:5750-5754, 1996
33. 2 in human colon cancer cells. Cancer Res 58:362-366, 1998
34. Sirois J, Richards JS: Transcriptional regulation of the rat prostaglandin endoperoxide synthase 2 gene in granulose cells. Evidence for the role of a cis-acting C/EBPβ promoter element. J Biol Chem 268:21931-21938, 1993
35. Stalla GK, Stalla J, Huber M, Loeffier JP, Hollt V, von Werder K, Muller OA: Ketoconazole inhibits corticotropic cell function in vitro. Endocrinology 122:618-623, 1988
36. Stalla GK, Stalla J, von Werder K, Muller OA, Gerzer R, Hollt V, Jakobs KH: Nitroimidazole derivatives inhibit anterior pituitary cell function apparently by a direct effect on the catalytic subunit of the adenylate cyclase holoenzyme. Endocrinology 125:699-706, 1989
37. Takahashi Y, Taketani Y, Endo T, Yamamoto S, Kumegawa M: Studies on the induction of cyclooxygenase isozymes by various prostaglandins in mouse osteoblastic cell line with reference to signal transduction pathways. Biochim Biophys Acta 1212:217-224, 1994
38. Tang Q, Chen W, Gonzales MS, Finch J, Inoue H, Bowden GT: Role of cyclic AMP responsive element in the UVB induction of cyclooxygenase-2 transcription in human keratinocytes. Oncogene 20:5164-5172, 2001
39. 2 in human prostatic carcinoma cells. Br J Cancer 75:1111-1118, 1997
40. Trachtenberg J, Pont A: Ketoconazole therapy for advanced prostate cancer. Lancet 8400(ii):433-435, 1984
41. Tsuji M, DuBois RN: Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 83:493-501, 1995
42. Umayahara Y, Ji C, Centrella M, Rotwein P, McCarthy TL: CCAAT/enhancer-binding protein δ activates insulin-like growth factor-I gene transcription in osteoblasts. Identification of a novel cyclic AMP signaling pathway in bone. J Biol Chem 272:31793-31800, 1997
43. Wolff DJ, Datto GA, Samatovicz RA: The dual mode of inhibition of calmodulin-dependent nitric-oxide synthase by antifungal imidazole agents. J Biol Chem 268:9430-9436, 1993
44. Yanagi Y, Komatsu T: Inhibition of prostaglandin biosynthesis by SL-573. Biochem Pharmacol 25:937-941, 1976