GABA-benzodiazepine receptor complex in brain oxidative metabolism regulation

Pharmacological Research

Volumn 46, Issue 2, 2002, Pages 149-154

  Obradović, Dragan I ^a   Bokonjić, Dubravko R ^b   Savić, Miroslav M ^c   Andjelković, Draginja S ^a   Ugrešić, Nenad D ^c   Stojiljković, Miloš P ^b  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b UNIVERSITY OF DEFENCE   (Serbia)

^c UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Cerebral cortex slices; Diazepam; GABA; GABAA benzodiazepine receptor; Oxygen consumption

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE RECEPTOR; DIAZEPAM; FLUMAZENIL; PICROTOXIN;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN OXYGEN CONSUMPTION; BRAIN SLICE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; FRONTAL CORTEX; MALE; METABOLIC REGULATION; NONHUMAN; POLAROGRAPHY; PRIORITY JOURNAL; RAT;

EID: 0036421221     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-6618(02)00079-8     Document Type: Article

References (25)

1. Kirvela OA, Kanto JH. Clinical and metabolic responses to different types of premedication. Anaesth Analg 1991; 73: 49-53.
2. Kirvela OA, Katila A, Aantaa R, Kanto JH, Himberg JJ. Metabolic and subjective responses to oral diazepam and midazolam. Eur J Anaesthesiol 1994; 11: 365-9.
3. Nugent M, Artru AA, Michenfelder JD. Cerebral metabolic, vascular and protective effects of midazolam maleate, comparison to diazepam. Anesthesiology 1982; 56: 172-6.
4. Maekawa T, Oshibuchi T, Imamura A, Takeshita H. Effects of psychotropic drugs on the cerebral energy state and glykolytic metabolism in the rat: Diazepam, clomipramine and chlorpromazine. Biochem Pharmacol 1980; 29: 15-8.
5. Carlsson C, Hagerdal M, Kaasik AE, Siesjo BK. The effects of diazepam on cerebral blood flow and oxygen consumption in rats and its synergistic interaction with nitrous oxide. Anesthesiology 1976; 45: 319-25.
6. Matthew CB, Hubbard RW, Francesconi RP. Atropine, diazepam, and physostigmine: Thermoregulatory effects in the heat-stressed rat. Life Sci 1989; 44: 1921-7.
7. McCabe RT, Wamsley JK. Autoradiographic localization of subcomponents of the macromolecular GABA receptor complex. Life Sci 1986; 39: 1937-45.
8. McIlwain H, Bachelard HS. Metabolic, ionic and electrical phenomena in separated cerebral tissues: Cerebral lipids. In: McIlwain H, Bachelard HS, eds. Biochemistry and the Central Nervous System. New York: Churchill Livingstone, 1985: 54-83.
9. A receptors. Brain Res Rev 1999; 29: 196-217.
10. Ahn CS, Tow DE, Yu C-C, Greene RW. Effect of metabolic alterations on the accumulation of technetium-99m-labeled d, l-HMPAO in slices of rat cerebral cortex. J Cereb Blood Flow Metab 1994; 14: 324-31.
11. Robinson JR, Cooper JM. Method of determining oxygen concentrations in biological media, suitable for calibration of the oxygen electrode. Anal Biochem 1970; 33: 390-9.
12. Hertz L, Schou M. Univalent cations and the respiration of brain-cortex slices. Biochem J 1962; 85: 93-104.
13. Izquierdo I. A game with shifting mirrors. Trends Pharmacol Sci 1989; 10: 473-6.
14. Osmanovic SS, Shefner SA. γ-Aminobutyric acid responses in rat locus coeruleus neurons in vitro: a current-clamp and voltage-clamp study. J Physiol (Lond) 1990; 421: 151-70.
15. Krnjevic K. Some functional consequences of GABA uptake by brain cells. Neurosci Lett 1984; 47: 283-7.
16. Cooper JR, Bloom FE, Roth RH. The Biochemical Basis of Neuropharmacology. New York: Oxford University Press, 1986: 390-9.
17. Michenfelder JD, Milde JH, Katusic ZS. Postischemic canine cerebral blood flow is coupled to cerebral metabolic rate. J Cereb Blood Flow Metab 1991; 11: 611-6.
18. Galeffi F, Sinnar S, Schwartz-Bloom RD. Diazepam promotes ATP recovery and prevents cytochrome c release in hippocampal slices after in vitro ischemia. J Neurochem 2000; 75: 1242-9.
19. Albertson TE, Bowyer JF, Paule MG. Modification of the anticonvulsant efficacy of diazepam by Ro 15-1788 in the kindled amygdaloid seizure model. Life Sci 1982; 31: 1597-601.
20. Nutt DJ, Cowen PJ, Little HJ. Unusual interactions of benzodiazepine receptor antagonists. Nature 1982; 295: 436-8.
21. Vellucci SV, Webster RA. Is Ro 15-1788 a partial agonist at benzodiazepine receptors? Eur J Pharmacol 1983; 90: 263-8.
22. A receptors: Classification on the basis of subunit structure and receptor function. Pharmacol Rev 1998; 50: 291-313.
23. Pirker S, Schwarzer C, Wieselthaler A, Sieghart W, Sperk G. GABAA receptors: Immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience 2000; 101: 815-50.
24. Marangos PJ, Martino AM. Studies on the relationship of gamma-aminobutyric acid-stimulated diazepam binding and the GABA receptor. Mol Pharmacol 1981; 20: 16-21.
25. De Robertis E, Pena C, Paladini AC, Medina JH. New developments on the search for the endogenous ligand(s) of central benzodiazepine receptors. Neurochem Int 1988; 13: 1-11.