A rare, in-frame BCR-ABL fusion (e13a3) in a patient with an aggressive chronic myeloid leukaemia

Acta Haematologica

Volumn 108, Issue 3, 2002, Pages 150-153

  Otazú, Ivone B ^a,b   Belén Rivero, María ^a,b   Olício, Renata ^a,b   Pinto, Augusto ^b   Zalcberg, Ilana ^a   Seuánez, Héctor N ^a,b  

^a INSTITUTO NACIONAL DE CÂNCER   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

b2a3 chimaeric gene; BCR ABLrearrangement; cDNA sequencing; Chronic myeloid leukaemia; RT PCR

Indexed keywords

BCR ABL PROTEIN; COMPLEMENTARY DNA;

ADULT; ARTICLE; CASE REPORT; CHIMERA; CHRONIC MYELOID LEUKEMIA; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; DNA SEQUENCE; EXON; GENE FUSION; GENE REARRANGEMENT; HUMAN; MALE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; FUSION PROTEINS, BCR-ABL; HUMANS; LEUKEMIA, MYELOID, CHRONIC; MALE; TRANSLOCATION, GENETIC;

EID: 0036419402     PISSN: 00015792     EISSN: None     Source Type: Journal    
DOI: 10.1159/000064701     Document Type: Article

References (15)

1. Heisterkamp N, Groffen J: Molecular insight into the Philadelphia translocation. Haematol Pathol 1991;5:1-10.
2. Ben Neriah Y, Daley GQ, Mes-Masson AM, Witte ON, Baltimore D: The chronic myelogenous leukemia specific p210 protein is the product of the BCR-ABL hybrid gene. Science 1986;233:212.
3. Chan LC, Kahy KK, Rayter SI, Heisterkamp N, Eridani S, Powles R, Lawler SD, Groffen J, Foutkes JG, Greaves ML, Wiedemann L: A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia. Nature 1987;325:635-637.
4. How GF, Tan LT, Lim LC: Chronic myeloid leukemia with a19a2 (c3a2) BCR/ABL fusion-junction - Is it truly a benign disease? Leukemia 1998;12:1166-1167.
5. Melo JV: The diversity of BCR-ABL fusion protein and their relationship to leukemia phenotype. Blood 1996;88:2375-2384.
6. Soekarman D, van Denderen J, Hoefsloot L, Moret M, Meeuwsen T, van Baal J, Hagemeijer A, Grosveld G: A novel variant of the BCR-ABL fusion product in Philadelphia chromosome positive acute lymphoblastic leukemia. Leukemia 1990;4:397-403.
7. van Der Plas DC, Soekarman D, van Gent AM, Grosveld G, Hagemeijer A: BCR-ABL mRNA lacking abl exon a2 detected by polymerase chain reaction in a chronic myelogeneous leukemia. Leukemia 1991;5:457-461.
8. Inukai T, Sugita K, Suzuki T, Ijima K, Goy K, Tezuka T, Kojika S, Hatakeyama K, Kagami K, Mori T, Okazaki T, Mizutani S, Nakazawa S: A novel 203 kD aberrant BCR-ABL product in a girl with Philadelphia chromosome positive acute lymphoblastic leukaemia. Br J Haematol 1993;85:823-825.
9. Iwata S, Mizutani S, Nakazawa S, Yata J-I: Heterogeneity of the breakpoint in the ABL gene in cases with BCR/ABL transcript lacking ABL exon a2. Leukemia 1994;8:1696-1702.
10. Martinelli G: Concomitant expression of the rare E1/A3 and B2/A3 types of BCR/ABL transcript in a chronic myeloid leukaemia (CML) patient. Leukemia 1999;13:1463-1464.
11. Otazu IB, Zalcberg I, Dobbin J, Tabak D, Seuánez HN: Detection of BCR-ABL transcripts by multiplex and nested PCR in different haematological disorders. Leuk Lymph 2000;37:205-211.
12. Burmeister T, Maurer J, Aivado M, Elmaagacli AH, Grunebach F, Held KR, Hess G, Hochhaus A, Hoppner W, Lentes KU, Lubbert M, Schafer KL, Schaufhausen P, Schmidt CA, Schuler F, Seeger K, Seelig R, Thiede C, Viehmann S, Weber C, Wilhelm S, Christmann A, Clement JH, Ebener U, Enczmann J, Leo R, Schleuning M, Schoch R, Thiel E: Quality assurance in RT-PCR-based BCR/ABL diagnostics - Results of an interlaboratory test and a standardization approach. Leukemia 2000;14: 1850-1856.
13. Sege-Peterson K, Chambers J, Page T, Jones OW, Nyhan WL: Characterization of mutations in phenotypic variants of hypoxanthine phosphoribosyltransferase deficiency. Hum Mol Genet 1992;1:427-432.
14. Hochhaus A, Reiter A, Skladny H, Melo JV, Sick C, Berger U, Guo JQ, Arlinghaus RB, Hehlmann R, Goldman JM, Cross NCP: A novel BCR-ABL fusion gene (e6a2) in a patient with Philadelphia chromosome negative chronic myelogeneous leukemia. Blood 1996; 88:2236-2240.
15. Pendergast AM, Muller AJ, Havlik MH, Maru Y, Witte ON: BCR sequences essential for transformation by the BCR/ABL oncogene being to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner. Cell 1991;66:161-171.