The effect of low intensity pulsed ultrasound on regenerate bone in a less-than-rigid biomechanical environment

Bio-Medical Materials and Engineering

Volumn 12, Issue 3, 2002, Pages 239-247

  Shaun Machen, M ^a   Tis, John E ^b   Inoue, Nozomu ^a   Meffert, Rainer H ^b   Chao, Edmund Y S ^a,b   McHale, Kathleen A ^a  

^a WALTER REED ARMY MEDICAL CENTER   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Distraction osteogenesis; External fixation; Rabbit model; Torsional test; Ultrasound

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE DENSITY; BONE RADIOGRAPHY; BONE REGENERATION; CALLUS; CARTILAGE; CONTROLLED STUDY; DISTRACTION OSTEOGENESIS; DUAL ENERGY X RAY ABSORPTIOMETRY; FRACTURE HEALING; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; RABBIT; TIBIA; TIBIA OSTEOTOMY; ULTRASOUND;

ANIMALS; BIOMECHANICS; BONE DENSITY; BONE REGENERATION; ELASTICITY; OSTEOGENESIS, DISTRACTION; RABBITS; REFERENCE VALUES; SINGLE-BLIND METHOD; STRESS, MECHANICAL; TIBIA; TORQUE; ULTRASONICS;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0036409511     PISSN: 09592989     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Y. Azuma, M. Ito, Y. Harada, H. Takagi, T. Ohta and S. Jingushi, Low-intensity pulsed ultrasound accelerates rat femoral fracture healing by acting on the various cellular reactions in the fracture callus, J. Bone Miner. Res. 16 (2001), 671-680.
2. J.D. Heckman, J.P. Ryaby, J. McCabe, J.J. Frey and R.F. Kilcoyne, Acceleration of tibial fracture-healing by non-invasive, low-intensity pulsed ultrasound, J. Bone Joint Surg. [Am] 76 (1994), 26-34.
3. T.S. Whitecloud 3rd, S.D. Cook, S.L. Salkeld and J.P. Ryaby, Acceleration of spine fusions with a low intensity pulsed ultrasound device, Trans. Orthop. Res. Soc. 23 (1998), 1049.
4. A.A. Pilla, M.A. Mont, P.R. Nasser et al., Non-invasive low intensity pulsed ultrasound accelerates bone healing in the rabbit, J. Orthop. Trauma 4 (1990), 246-253.
5. E. Mayr, A. Laule, G. Suger, L. Claes and A. Ruter, Regenerate maturation aided by low intensity ultrasound in callus distraction, in: Transaction of the 6th International Society of Fracture Repair, 1998, pp. 56-57.
6. J.T. Ryaby, E.J. Bachner, J.A. Bendo, P.F. Dalton, S. Tannenbaum and A.A. Pilla, Low intensity pulsed ultrasound increases calcium incorporation in both differentiating cartilage and bone cell cultures, Trans. Orthop. Res. Soc. 14 (1989), 15.
7. A.A. Spirit, J.F. Greenleaf, A.S. Sanyal, R.R. Kinnick and S.W. O'Driscoll, Low intensity ultrasound induces cartilage-specific gene expression in periosteal explants, Trans. Orthop. Res. Soc. 23 (1998), 513.
8. K.H. Yang, J. Parvizi, S. Wang et al., Exposure to low intensity ultrasound increases aggregan gene expression in a rat femur fracture model, J. Orthop. Res. 14 (1996) 802-809.
9. J.T. Ryaby, P. Duarte-Alves and A.A. Pilla, Clinically effective ultrasound effects second messenger activity in bone cell cultures, Trans. BRAGS 9 (1989), 42.
10. J. Behari and S. Singh, Ultrasound propagation in in vivo bone, Ultrasonics 19 (1981), 87-90.
11. J.J. Wu, H.S. Shyr, E.Y.S. Chao and P.J. Kelly, Comparison of osteotomy healing under external fixation devices with different stiffness characteristics, J. Bone Joint Surg. [Am] 66 (1984), 1258-1264.
12. G. Ilizarov, Clinical application of the tension-stress effect for limb lengthening, Clin. Orthop. 250 (1990), 8-21.
13. L.E. Claes, C.A. Heigele, C. Neidlinger-Wilke et al., Effects of mechanical factors on the fracture healing process, Clin. Orthop. 355S (1998), S132-147.
14. S. Wang, D.G. Lewallen, M.E. Bolander, E.Y.S. Chao, D.M. Ilstrup and J.F. Greenleaf, Low intensity ultrasound treatment increases strength in a rat femoral fracture model, J. Orthop. Res. 12 (1994), 40-47.
15. C.A.M. Xavier and L.R. Duarte, Estimulaci ultra-sonica de callo osseo: Applicaca clinica, Rev. Brasiliera Orthop. 18 (1983), 73-80.
16. M. Tanzer, E. Harvey, A. Kay, P. Morton and J.D. Bobyn, Effect of noninvasive low intensity ultrasound on bone growth into porous-coated implants, J. Orthop. Res. 14 (1996), 901-906.
17. M. Richards, J.A. Goulet, J.A. Weiss, N.A. Waanders, M.B. Schaffler and S.A. Goldstein, Bone regeneration and fracture healing. Experience with distraction osteogenesis model, Clin. Orthop. 355S (1998), S191-204.
18. B. Kassis, C. Glorion, W. Tabib, O. Blanchard and J.C. Pouliquen, Callus response to micromovement after elongation in the rabbit, J. Pediatr. Orthop. 16 (1996), 480-483.
19. J. Wu and J. Du, Temperature elevation in tissues generated by fine amplitude tone bursts of ultrasound, J. Acoust. Soc. Am. 88 (1990), 1562-1577.
20. H.G. Welgus, J. Jeffrey and A.Z. Eisen, Human skin fibroblasts collagenase. Assessment of activation energy and deuterium isotope effect with collagenous substrates, J. Biol. Chem. 256 (1981), 9516-9521.
21. L.R. Duarte, The stimulation of bone growth by ultrasound, Arch. Orthop. Trauma Surg. 101 (1983), 153-159.
22. R.H. Meffert, J.E. Tis, S. Lounici, J.S. Rogers, N. Inoue and E.Y. Chao, Comparison of two systems for tibial external fixation in rabbits, Lab. Anim. Sci. 49 (1999), 650-654.
23. H. Kojimoto, Y. Natsuo, G. Tatsuhiko, M. Shigezo and S. Yutaka, Lengthening in rabbits by callus distraction. The role of periosteum and endosteum, J. Bone Joint Surg. [Br] 70 (1988), 543-549.
24. R.H. Meffert, J.E. Tis, N. Inoue, E.F. McCarthy, E. Brug and E.Y. Chao, Primary resective shortening followed by distraction osteogenesis for limb reconstruction: A comparison with simple lengthening, J. Orthop. Res. 18 (2000), 629-636.
25. R.H. Meffert, N. Inoue, J.E. Tis, E. Brug and E.Y. Chao, Distraction osteogenesis after acute limb-shortening for segmental tibial defects. Comparison of a monofocal and a bifocal technique in rabbits, J. Bone Joint Surg. [Am] 82 (2000), 799-808.