Exposure to low-intensity ultrasound increases aggrecan gene expression in a rat femur fracture model

Journal of Orthopaedic Research

Volumn 14, Issue 5, 1996, Pages 802-809

  Yang, K H ^a   Parvizi, J ^a   Wang, S J ^a   Lewallen, D G ^a   Kinnick, R R ^a   Greenleaf, J F ^a   Bolander, M E ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BONE; COLLAGEN; GENES; LIVING SYSTEMS STUDIES; LOADS (FORCES); PHYSIOLOGICAL MODELS; STIFFNESS; ULTRASONIC APPLICATIONS;

AGGRECAN GENE EXPRESSION; DIAPHYSEAL INJURY; FEMUR FRACTURE; ULTRASOUND STIMULATION;

FRACTURE FIXATION;

AGGRECAN; PROCOLLAGEN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE REMODELING; CHONDROGENESIS; COLLAGEN SYNTHESIS; DIAPHYSIS; ECHOGRAPHY; EXTRACELLULAR MATRIX; FEMUR FRACTURE; FRACTURE HEALING; MECHANICAL STRESS; NONHUMAN; PRIORITY JOURNAL; RAT; TORQUE;

EID: 0030250583     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1002/jor.1100140518     Document Type: Article

References (41)

1. 1 Aro HT, Chao EY: Biomechanics and biology of fracture repair under external fixation. Hand Clin 9: 531–542, 1993
2. 2 Behari J, Singh S: Ultrasound propagation in „in vivo”︁ bone. Ultrasonics 19: 87–90, 1981
3. 3 Bonnarens F, Einhorn TA: Production of a standard closed fracture in laboratory animal bone. J Orthop Res 2: 97–101, 1984
4. 4 Burdette EC, Svensson GK, Lu X‐Q. Hansen JL, Slayton MH. Foard WW, Neubauer PL, Admire PJ, VanGundy MT, Bandyopadhyay S, Bornstein BA, Harris JR: Ultrasound hyperthermia system for breast cancer treatment. In: 1994 Ultrasonics Symposium, pp 1873–1877, IEEE, 1994
5. 5 Brighton CT, Friedlaender GE, Lane JM [ed]: Bone Formation and Repair, pp 115–185. Rosemont, Illinois, American Academy of Orthopaedic Surgeons, 1994
6. 6 Carstensen EL, Child SZ, Norton S, Nyborg W: Ultrasonic heating of skull. J Acoust Soc Am 87: 1310–1317, 1990
7. 7 Danis R: The classic. The aims of internal fixation. Clin Orthop 138: 23–25, 1979
8. 8 De Bastiani G, Aldegheri R, Renzi‐Brivo L: Treatment of fractures with a dynamic axial fixator. J Bone Joint Surg [Br] 66: 538–545, 1984
9. 9 Duarte LR: The stimulation of bone growth by ultrasound. Arch Orthop Trauma Surg 101: 153–159, 1983
10. 10 Dyson M, Brookes M: Stimulation of bone repair by ultrasound. Ultrasound Med Biol 2 (Suppl): 61–66, 1983
11. 11 Dyson M: Non‐thermal cellular effects of ultrasound. Br J Cancer 45: 165–171, 1982
12. 12 Egger EL, Gottsauner‐Wolf F, Palmer J, Aro HT, Chao EY: Effects of axial dynamization on bone healing. J Trauma 34: 185–192, 1993
13. 13 Enwemeka CS, Rodriguez O, Mendosa S: The biomechanical effects of low‐intensity ultrasound on healing tendons. Ultrasound Med Biol 16: 801–807, 1990
14. 14 Goodship AE, Watkins PE, Rigby HS, Kenwright J: The role of fixator frame stiffness in the control of fracture healing: an experimental study. J Biomech 26: 1027–1035, 1993
15. 15 Hasegawa S, Sato S, Saito S, Suzuki Y, Brunette DM: Mechanical stretching increases the number of cultured bone cells synthesizing DNA and alters their pattern of protein synthesis. Calcif Tissue Int 37: 431–436, 1985
16. 16 Heckman JD, Ryaby JP, McCabe J, Frey JJ, Kilcoyne RF: Acceleration of tibia fracture‐healing by non‐invasive lowintensity pulsed ultrasound. J Bone Joint Surg [Am] 76: 26–34, 1994
17. 17 Hill CR: Ultrasonic exposure thresholds for changes in cells and tissues. J Acoust Soc Am 52: 667–672, 1971
18. 18 Jingushi S, Joyce ME, Bolander ME: Genetic expression of extracellular matrix proteins correlates with histologic changes during fracture repair. J Bone Miner Res 7: 1045–1055, 1992
19. 19 Joyce ME, Jingushi S, Bolander ME: Transforming growth factor‐beta in the regulation of fracture repair. Orthop Clin North Am 2: 199–209, 1990
20. 20 Klug W, Franke W‐G, Knoch H‐G: Scintigraphic control of bone‐fracture healing under ultrasonic stimulation: an animal experimental study. Eur J Nucl Med 11: 494–497, 1986
21. 21 Knoch H‐G, Klug W: Stimulation of Fracture Healing with Ultrasound, pp 1–80. Berlin, Springer‐Verlag, 1990
22. 22 Labarca C, Paigen K: A simple, rapid and sensitive DNA assay procedure. Annal Biochem 102: 344–352, 1980
23. 23 Layman DL, McGoodwin EB, Martin GR: The nature of the collagen synthesized by cultured human fibroblasts. Proc Natl Acad Sci USA 68: 454–458, 1971
24. 24 Macey LR, Kana SM, Jingushi S, Terek MR, Borretos J, Bolander ME: Defects of early fracture‐healing in experimental diabetes. J Bone Joint Surg [Am] 71: 722–733, 1989
25. 25 Mortimer AJ, Dyson M: The effect of therapeutic ultrasound on calcium uptake in fibroblasts. Ultrasound Med Biol 14: 499–506, 1988
26. 26 Nemeth GG, Heydemann A, Bolander ME: Isolation and analysis of ribonucleic acids from skeletal tissues. Anal Biochem 183: 301–304, 1989
27. 27 Perren SM, Cordey J: The concept of intrafragmentary strain. In: Current Concepts of Internal Fixation of Fractures, pp 63–77. Ed by HK Uhthoff. Berlin, Springer‐Verlag, 1980
28. 28 Pilla AA, Mont MA, Nasser PR, Kahn SA, Figueiredo M, Kaufman JJ, Siffert RS: Non‐invasive low‐intensity pulsed ultrasound accelerates bone healing in the rabbit. J Orthop Trauma 4: 246–253, 1990
29. 29 Ryaby JT, Bachner EJ, Bendo JA, Dalton PF, Tannenbaum S, Pilla AA: Low intensity pulsed ultrasound increases calcium incorporation in both differentiating cartilage and bone cell culture. Trans Orthop Res Soc 14: 15, 1989
30. 30 Sachs F: Mechanical transduction by membrane ion channels: a mini review. Mol Cell Biochem 104: 57–60, 1991
31. 31 Sandberg MM, Aro HT, Vuorio EL: Gene expression during bone repair. Clin Orthop 289: 292–312, 1993
32. 32 Simon SR [ed]: Orthopaedic Basic Science. Rosemont, Illinois, American Academy of Orthopaedic Surgeons, 1994
33. 33 Suslick KS [ed]: Ultrasound: Its Chemical, Physical, and Biological Effects. New York, VCH Publishers, 1988
34. 34 Wang N, Butler JP, Ingber DE: Mechanotransduction across the cell surface and through the cytoskeleton. Science 260: 1124–1127, 1993
35. 35 Wang S‐J, Lewallen DG, Bolander ME, Chao EYS, Ilstrup DM, Greenleaf JF: Low intensity ultrasound treatment increases strength in a rat femoral fracture model. J Orthop Res 12: 40–47, 1994
36. 36 Webster DF, Pond JB, Dyson M, Harvey W: The role of cavitation in the in vitro stimulation of protein synthesis in human fibroblasts by ultrasound. Ultrasound Med Biol 4: 343–351, 1978
37. 37 Webster DF, Harvey W, Dyson M, Pond JB: The role of ultrasound‐induced cavitation in the „in vitro”︁ stimulation of collagen synthesis in human fibroblasts. Ultrasonics 18: 33–37, 1980
38. 38 White AA III, Panjabi MM, Southwick WO: The four biomechanical stages of fracture repair. J Bone Joint Surg [Am] 59: 188–192, 1977
39. 39 Williams AR: Attenuation, scattering and absorption. In: Ultrasound: Biological Effects and Potential Hazards, pp 83–97, London, Academic Press, 1983
40. 40 Wolff J: Das Gesetz der Transformation der Knochen. Berlin, Hirschwald, 1892
41. 41 Ziskin MC: Applications of ultrasound in medicine: comparison with other modalities. In: Ultrasound: Medical Applications, Biological Effects and Hazard Potential, pp 49–61. Ed by MH Repacholi, M Grandolfo, and A Rindi. New York, Plenum. 1987