Immunomodulatory effects of peptide T on human keratinocyte cells

British Journal of Dermatology

Volumn 147, Issue 4, 2002, Pages 663-669

  Tufano, M A ^a   Greco, R ^a   Paoletti, I ^a   Donnarumma, G ^a   Canozo, N ^a   Baroni, A ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

v integrins; Heat shock protein 70; HIV 1 gp120; Reverse transcriptase polymerase chain reaction; Transforming growth factor

Indexed keywords

HEAT SHOCK PROTEIN 70; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; PEPTIDE T; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ARTICLE; CELL CONTACT; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXTRACTION; HUMAN; HUMAN CELL; IMMUNOMODULATION; KERATINOCYTE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADULT; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; GENE EXPRESSION REGULATION; HSP70 HEAT-SHOCK PROTEINS; HUMANS; INTEGRIN ALPHA CHAINS; INTERCELLULAR ADHESION MOLECULE-1; KERATINOCYTES; PEPTIDE T; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 0036405033     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2133.2002.04915.x     Document Type: Article

References (35)

1. Asadullah K, Docke WD, Ebeling M et al. Interleukin-10 treatment of psoriasis. Arch Dermatol 1999; 135: 187-92.
2. Asadullah K, Sabat R, Wiese A et al. Interleukin-10 in cutaneous disorders: implications for its pathophysiological importance and therapeutic use. Arch Dermatol Res 1999; 291: 628-36.
3. 3 and calcipotriol induce IL-10 receptor gene expression in human epidermal cells. Inflamm Res 1997; 46: 32-4.
4. Raychaudhuri SP, Farber EM, Raychaudhuri SK. Immunomodulatory effects of peptide T on Th 1/Th 2 cytokine. Int J Immunopharmacol 1999; 21: 609-15.
5. Uyemura K, Yamamura M, Fivenson DF et al. The cytokine network in lesional and lesion-free psoriatic skin is characterized by a T-helper type 1 cell mediated response. J Invest Dermatol 1993; 101: 701-5.
6. Raychaudhuri SK, Raychaudhuri SP, Faber EM. Anti-chemotactic activities of peptide T: A possible mechanism of actions for its therapeutic effects on psoriasis. Int J Immunopharmacol 1998; 20: 661-7.
7. Sporn MB, Roberts AB. Transforming growth factor β: Recent progress and new challenges. J Cell Biol 1992; 119: 1017-21.
8. Leivo T, Leivo I, Kariniemi AL et al. Down-regulation of transforming growth factor-beta receptors I and II is seen in lesional but not non-lesional psoriatic epidermis. Br J Dermatol 1998; 138: 57-62.
9. Schmid P, Cox D, Bilbe G et al. TGF-βs and TGF-β type II receptor in human epidermis: Differential expression in acute and chronic skin wounds. J Pathol 1993; 171: 191-7.
10. Sheppard D, Rozzo C, Starr L et al. Complete aminoacid sequence of a novel integrin β subunit (β6) identified in epithelial cells using the polymerase chain reaction. J Biol Chem 1990; 265: 11502-7.
11. Zambruno G, Marchisio PC, Marconi A et al. Transforming growth factor-β1 modulates β1 and β5 integrin receptors and induces the de novo expression of the αvβ6 heterodimer in normal human keratinocytes: Implication, for wound healing. J Cell Biol 1995; 129: 853-65.
12. Hynes RO. Integrins: Versatility, modulation and signaling in cell adhesion. Cell 1992; 69: 11-25.
13. Rouslahti E. Integrins. J Clin Invest 1991; 87: 1-5.
14. Schwartz MA. Integrins, oncogenes and anchorage independence. J Cell Biol 1997; 139: 575-8.
15. De Luca M, Pellegrini G, Zambruno G, Marchisio PC. Role of integrins in cell adhesion and polarity in normal keratinocytes and human skin pathologies. J Dermatol 1994; 21: 821-8.
16. Pellegrini G, Luca M, Orecchia G et al. Expression, topography and function of integrin are severely altered in keratinocytes from involved and uninvolved psoriatic skin. J Clin Invest 1992; 89: 1783-95.
17. Cao Y, Ohwatari N, Matsumoto T et al. TGF-β1 mediates 70-kDa heat shock protein induction due to ultraviolet irradiation in human skin fibroblasts. Pfugers Arch Eur J Physiol 1999; 438: 239-44.
18. Fenton WA, Horwich AL. GroEL-mediated protein folding. Protein Sci 1997; 6: 743-60.
19. Kaufman SHE. Heat shock proteins and the immune response. Immunol Today 1990; 11: 129-36.
20. Morimoto RI. Heat shock: The role of transient inducible responses in cell damage, transformation and differentiation. Cancer Cells 1991; 3: 297-301.
21. Morimoto RI, Tissières A, Georgopoulo C. Introduction to stress proteins. In: The Role of Heat Shock and Stress Response in Biology and Human Disease (Morimoto R.I., Tissieres A, eds). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1989; 1-30.
22. Boyce ST, Ham RG. Calcium regulated differentiation of normal human epidermal keratinocytes in chemically defined clonal culture and serum free serial culture. J Invest Dermatol 1983; 81: 33-40.
23. Bradford M. A rapid and sensitive method for the quantification of microgram quantities of protein utilising the principle of protein binding. Anal Biochem 1976; 72: 248-56.
24. Farber EF, Cohen EN, Trozak DJ, Wilkinson DI. Peptide T improves psoriasis when infused into lesions in nanogram amounts. Am Acad Dermatol 1991; 25: 658-64.
25. Talme T, Rozell BL, Sundquist KG et al. Histopathological and immunohistochemical changes in psoriatic skin during peptide T treatment. Arch Dermatol Res 1995; 287: 553-7.
26. Bjerke JR, Haukenes G, Livden JK et al. Activated T lymphocytes, interferon and retrovirus-like particles in psoriatic lesions. Arch Dermatol 1983; 119: 955-6.
27. Johansson O, Hilliges M, Talme T et al. Somatostatin immunoreactive cells in lesional psoriatic human skin during peptide T treatment. Acta Derm Venereol 1994; 74: 106-9.
28. Talme T, Jund-Russel B, Sunquist KG et al. Peptide T: A new treatment of psoriasis? A review of our experiences. Acta Derm Venereol (Stockh) 1994; 186 (Suppl.): 76-8.
29. Dustin ML, Singer KH, Tuck DT, Springer TA. Adhesion of T lymphoblast to epidermal keratinocytes is regulated by interferon-γ and is mediated by intercellular adhesion molecule-1 (ICAM-1). J Exp Med 1988; 167: 13-23.
30. Shipley GD, Pittelkow MR, Willie JJ Jr et al. Reversible inhibition of normal human prokeratinocyte proliferation by type β transforming growth factor- growth inhibitor in serum-free medium. Cancer Res 1986; 46: 2068-71.
31. Reiss M, Sartorelli AC. Regulation of growth and differentiation of human keratinocytes by type β transforming growth factor and epidermal growth factor. Cancer Res 1987; 47: 6705-9.
32. Welch WJ. Mammalian stress response: Cell physiology, structure/function stress proteins, and implications for medicine and disease. Physiol Rev 1992; 72: 1063-81.
33. Gailit J, Welch MP, Clark RA. TGF-beta 1 stimulates expression of keratinocyte integrins during re-epithelialization of cutaneous wounds. J Invest Dermatol 1994; 103: 221-7.
34. Wikner NE, Persichitte KA, Baskin JB et al. Transforming growth factor-β stimulates the expression of fibronectin by human keratinocytes. J Invest Dermatol 1988; 91: 207-12.
35. Border WA, Ruoslahti E. Transforming growth factor-β in diseases: The dark side of tissue repair. J Clin Invest 1992; 90: 1-7.